Tuning Brain Stimulation Settings for People With Hard-to-Treat Epilepsy
Tests tuned brain stimulation settings in adults with drug-resistant epilepsy.
Plain-language title generated from the registry record
Registry title: Optimization of Deep Brain Stimulation Parameters in Patients With Medically Refractory Epilepsy
Key facts
- Where
- Minneapolis, United StatesSee the site
- Phase
- Early phase 1
Where in United States
- University of MinnesotaMinneapolis, United StatesTaking people
Questions to ask the study team
- How often do I need to come in, and for how long each time?
- Are travel costs paid?
- Can I keep my own doctor?
- What happens if I want to stop?
Trial details
- Who runs it
- University of Minnesota
- Trial code
- NCT05493722
- Record updated
- 16 October 2026
- Original description
Deep brain stimulation (DBS) is used to treat epilepsy in cases where patients are medically refractory and are not candidates for surgical resection. This therapy has been shown to be effective in seizure reduction, yet very few patients achieve the ultimate goal of seizure freedom. Implantable neural stimulators (INSs) have many parameters that may be adjusted, and could be tuned to achieve very patient specific therapies. This study will develop a platform for stimulation setting optimization based on power spectral density (PSD) measures.Read full original descriptionShow less
Optimization of Deep Brain Stimulation Parameters in Patients With Medically Refractory Epilepsy
Deep brain stimulation (DBS) is used to treat epilepsy in cases where patients are medically refractory and are not candidates for surgical resection. This therapy has been shown to be effective in seizure reduction, yet very few patients achieve the ultimate goal of seizure freedom. Implantable neural stimulators (INSs) have many parameters that may be adjusted, and could be tuned to achieve very patient specific therapies. This study will develop a platform for stimulation setting optimization based on power spectral density (PSD) measures.
Inclusion: medically refractory epilepsy; already have a deep brain stimulator in place.
Exclusion: severe dementia at investigator discretion.