MRI scans to find low-oxygen areas of brain tumour before radiotherapy
Tests MRI scans that detect low-oxygen areas in adults with glioblastoma brain tumour.
Plain-language title generated from the registry record
Registry title: MRI Hypoxia Study for Glioblastoma Multiforme (GBM) Radiation Therapy
Key facts
- Where
- St Leonards, AustraliaSee the 2 sites
Where in Australia
- North Shore Private HospitalSt Leonards, AustraliaNot yet recruiting
- Royal North Shore HospitalSt Leonards, AustraliaTaking people
Questions to ask the study team
- How often do I need to come in, and for how long each time?
- Are travel costs paid?
- Can I keep my own doctor?
- What happens if I want to stop?
Trial details
- Who runs it
- University of Sydney
- Trial code
- NCT05500612
- Record updated
- 19 May 2026
- Original description
This study is designed to evaluate the role of Oxygen Enhanced (OE) Magnetic resonance imaging (MRI) and Blood Oxygenation Level Dependent (BOLD) MRI in detecting regions of hypoxic tumour and to evaluate their use as imaging methods to selectively deliver targeted radiotherapy to regions of aggressive disease.Read full original descriptionShow less
Magnetic Resonance Imaging of Hypoxia for Radiation Treatment Guidance in Glioblastoma Multiforme (MANGO)
This study is designed to evaluate the role of Oxygen Enhanced (OE) Magnetic resonance imaging (MRI) and Blood Oxygenation Level Dependent (BOLD) MRI in detecting regions of hypoxic tumour and to evaluate their use as imaging methods to selectively deliver targeted radiotherapy to regions of aggressive disease.
Inclusion: Suspected high-grade glioma (HGG) / glioblastoma multiforme (WHO grade IV) at initial radiological examination; Eastern Cooperative Oncology Group (ECOG) performance status score of 0-2; Available for scanning on two separate days.
Exclusion: Patients who have received anti - vascular endothelial growth factor (anti-VEGF) monoclonal antibody therapy the 3 months prior to recruitment; Patients taking carbonic anhydrase inhibitors (Acetazolamide); Any implant, foreign body, 3 Tesla (3T) MRI incompatible device, or other contraindication to MRI imaging; Patients with a history of psychological illness or condition such as to interfere with the patient's ability to understand the requirements of the study; Patients with significant cardiac or pulmonary disease including cardiac arrythmias or Chronic Obstructive Pulmonary Disease (COPD) that are unable to tolerate high flow O2 for oxygen contrast; History of glaucoma; Patients with a history of severe renal disease(s) (eGFR <20) that cannot tolerate gadolinium chelate contrast agents; Women lactating, pregnant or of childbearing potential who are not willing to avoid pregnancy during the study; Geographically remote patients unable to agree to imaging schedule.