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Tests cervical cone biopsy in people with persistent HPV infection

Tests a cervical cone biopsy procedure in women with lasting HPV infection.

Plain-language title generated from the registry record
Registry title: Diagnostic Cervical Conization for Persistent Infection or Integration of HPV

Key facts

Where
Wuhan, ChinaSee the site

AI summary: who the study is looking for

From the trial's eligibility criteria. Machine-read from the registry text on this page, so it can be wrong. The registry text below and the trial team decide who can take part.

The trial is looking for women aged 25 to 70 with a long-lasting HPV infection or HPV integration, where doctors strongly suspect a cervical precancer even though a biopsy found none. Everyone has a cone-shaped piece of the cervix removed to check for disease.

Age
25 to 70 years
Sex
Women only
Disease stage
Abnormal cervical screening, but no precancerous lesions found on biopsy. Doctors strongly suspect cervical precancer, with at least one of: HPV type 16/18 infection for more than two years, more than 15 HPV integration reads, colposcopy that shows precancerous lesions, or a cervical TCT result of ASC-H/HSIL/SCC/AGC-FN/AIS/AC.
Biomarker or test result
HPV type 16/18 persistent infection for more than two years, or more than 15 HPV integration reads.

Main reasons for not taking part

  • Pregnant women
  • Vaginal intraepithelial neoplasia strongly suspected
  • Malignant tumor of another body system that has not been treated successfully
  • Acute inflammation of the lower genital or anal tract
  • Severe liver or kidney failure, blood disease or acute inflammation elsewhere that colposcopy and conization could seriously harm

Read by machine on 11 November 2026.

Could this be for you?

Answer for yourself. This is not a decision: only the study team can say whether you can take part.

  • Are you between 25 and 70 years old?

Source: NCT05510830, who can take part

Where in China

  • Tongji Hospital, Affiliated to Tongji Medical College of Huazhong University of Science and TechnologyWuhan, ChinaNo longer taking part

Questions to ask the study team

  1. How often do I need to come in, and for how long each time?
  2. Are travel costs paid?
  3. Can I keep my own doctor?
  4. What happens if I want to stop?

Contact the study team: see the registry record → Contacts and Locations

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Trial details

Who runs it
Tongji Hospital
Trial code
NCT05510830
Record updated
8 September 2022
Original description
For the patients with cervical persistent infection or integration of HPV, we has designed a program to perform cervical conization for certain patients to earlier and better diagnose and cure the diseases of HPV infection and related cervical intraepithelial neoplasia/cancer.Read full original descriptionShow less

A Study of the Value of Diagnostic Cervical Conization for Persistent Infection or Integration of Human Papillomavirus

For the patients with cervical persistent infection or integration of HPV, we has designed a program to perform cervical conization for certain patients to earlier and better diagnose and cure the diseases of HPV infection and related cervical intraepithelial neoplasia/cancer.

Inclusion: The patients are referred to colposcopy and biopsy examinations due to abnormal cervical screening results with no precancerous lesions discovered by pathology; The cervical precancerous lesions are highly suspected by clinicians with one or more following risk factors:; The course of HPV type 16/18 persistent infection is more than two years; The integration reads of HPV is more than 15; The impression of colposcopy indicates precancerous lesions; The cervical TCT indicates ASC-H/HSIL/SCC/AGC-FN/AIS/AC.

Exclusion: The patients are suffering malignant tumors of other system and have not been cured; The patients' health will be severely harmed by the colposcopy and cervical conization due to some circumstances such as severe insufficiency of liver and kidney function, blood diseases and acute inflammation of other systems; Pregnant women; Vaginal intraepithelial neoplasia is highly suspected by colposcopy and pathological examinations; There is acute inflammation of the lower genital or anal tract.

ClinicalTrials.gov NCT05510830