Building a database to study brain aneurysms and how they are managed
Collects data on intracranial aneurysm risk factors and treatment outcomes in adults.
Key facts
- Who runs it
- University Hospital, Geneva
- Where
- Cincinnati, San Francisco, and Virginia Beach, United StatesSee the 3 sitesAlso in 10 other countries, 19 sites
- Trial code
- Registry title
- @neurIST : Intregrated Biomedical Informatics for the Management of Cerebral Aneurysms
- Status
- Recruiting
- People taking part
- 20,000 people, planned
- Started
- 1 Jun 2015
- Expected to end
- 1 Mar 2040
- Type of study
- Observational, 4 groups
- Record updated
- 16 January 2026
Who can take part
AI summary
From the trial's eligibility criteria. Machine-read from the registry text on this page, so it can be wrong. The registry text below and the trial team decide who can take part.
The trial is looking for adults with a brain aneurysm (a bulge in a blood vessel in the brain), with or without bleeding. Family members and healthy volunteers can also join. Their data go into a research database.
- Age
- 18 Years and older
- Sex
- All sexes
- Disease stage
- Patients must have an intracranial aneurysm shown on blood vessel imaging (MRA, CTA or DSA). Patients with a ruptured aneurysm need the bleeding (subarachnoid haemorrhage) confirmed on CT or by lumbar puncture.
Main reasons for not taking part
- Not able to provide clinical data
- Refusing to give informed consent
The registry criteria, word for word
Show all 4 criteriaShow less
Who can take part
- able to provide consent or, in the event that a patient is incapable of providing consent, that a person is legally authorized to do so on behalf of the patient according to legal and ethical requirements of the country where the clinical centre is located; Patients:
- must have an angiographically proven intracranial aneurysm (MRA< CTA< DSA accepted).The determination of SAH requires the presence of a subarachnoid haemorrhage be verified on CT or by lumbar puncture; MRA: Magnetic Resonance Angiography CTA: Computed Tomography Angiography DSA: Digital Subtracted Angiography
Who cannot take part
- failure of a candidate to contribute clinical data,
- refusal to provide informed consent
Where in United States
Also in 10 other countries, 19 sites
- University of Cincinnati College of MedicineCincinnati, United StatesContact: Joseph BroderickTaking people
- University of CaliforniaSan Francisco, United StatesContact: Nerissa KoTaking people
- University of VirginiaVirginia Beach, United StatesContact: Bradford WorrallTaking people
About the trial
What the trial wants to find out
The primary aim of the SwissNeuroFoundation AneurysmDataBase Project is to implement information technology based tools to create and use a holistic reference database specific to intracranial aneurysms (IA).
Read full original descriptionShow less
The SwissNeuroFoundation AneurysmDataBase are concerned with generating the data with which to populate this database.
The purpose for populating the database are to:
* Screen for and evaluate markers of risk for intracranial aneurysm formation and aneurysm rupture. Are considered as markers the following: genetics factors, microbiota, environmental factors, congenital factors (ie: cerebrovascular anatomical variants), transcriptomics signature, proteomics signature,shape characteristics, haemodynamics characteristics. * Screen for and evaluate prognostic factors of outcome regarding different management strategies including watchful observation, microsurgical treatment, endovascular treatment or any combination thereof. * Implement and evaluate patient-specific management protocols integrating all available information. * Evaluate the impact of the database and use of tools to improve care, reduce costs, support knowledge discovery and promote new industrial developments.
The 4 groups in the trial
- IA Patients
Patients with one or more identified intracranial aneurysm, none of which are believed to have ruptured.
- IA + SAH Patients
Patients with one or more identified intracranial aneurysm, at least one of which has been radiologically or surgically determined to have ruptured.
- Familiy members
Individuals selected on review of a patient's family tree and contacted by said patient, who agree to be approached for recruitment. In affected families each member will be identified as: proband, affected, unaffected, unknown, or not genetically linked.
- Healthy Volunteers
Individuals, accompanying or contacted by a patient, or responding to open advertisement, or randomly selected in a defined population who agree to be approached for recruitment.
Questions to ask the study team
- How often do I need to come in, and for how long each time?
- Are travel costs paid?
- Can I keep my own doctor?
- What happens if I want to stop?
Contact the study team: see the registry record → Contacts and Locations
Print a page for my doctorData and sources
- Registry record
- Listed on ClinicalTrials.gov.
- Official title
- @neurIST : Informatique biomédicale intégrée Pour la Gestion Des anévrismes cérébraux
- Plain-language title
- Building a database to study brain aneurysms and how they are managedGenerated from the registry record. The registry title is the official one.
- AI summary
- From the trial's eligibility criteria. Read by machine on 14 November 2026.
- Publications
- Disentangling determinants of one-year modified Rankin scale in patients with incidentally detected solitary intracranial aneurysms.Computers in biology and medicine, 2026
- Record updated
- 16 January 2026