Supervised exercise program for teenagers receiving intensive cancer treatment
Tests a supervised exercise program in teenagers with cancer during intensive treatment.
Plain-language title generated from the registry record
Registry title: Exercise in Adolescents With Cancer
Key facts
- Where
- Madrid and Villaviciosa de Odón, SpainSee the 2 sites
AI summary: who the study is looking for
From the trial's eligibility criteria. Machine-read from the registry text on this page, so it can be wrong. The registry text below and the trial team decide who can take part.
The trial is looking for teenagers aged 12 to 19 with a newly diagnosed cancer outside the brain. It tests a supervised exercise program during intensive treatment.
- Age
- 12 to 19 years
- Sex
- All sexes can join.
- Disease stage
- Newly diagnosed malignant extracranial tumour (a cancer outside the brain). Adequate health status (Karnofsky score ≥50 or ECOG score ≤2).
- Earlier treatment
- Must not have had any therapy before diagnosis, except surgery.
Main reasons for not taking part
- Life expectancy under 3 months
- Another illness or acute condition that makes exercise unsafe
Read by machine on 9 November 2026.
Could this be for you?
Answer for yourself. This is not a decision: only the study team can say whether you can take part.
- Are you between 12 and 19 years old?
Source: NCT05539794, who can take part
Where in Spain
- UEMMadrid, SpainTaking people
- Universidad Europea de MadridVillaviciosa de Odón, SpainTaking people
Questions to ask the study team
- How often do I need to come in, and for how long each time?
- Are travel costs paid?
- Can I keep my own doctor?
- What happens if I want to stop?
Trial details
- Who runs it
- Universidad Europea de Madrid
- Trial code
- NCT05539794
- Record updated
- 22 July 2026
- Original description
The investigators will study the effects of an supevised exercise intervention along the duration of intensive treatment (neoadjuvant [solid tumours]/intense chemotherapy [leukemias], expected median duration 5-6 months) on several health-related variables. Participants will be recruited from 4 hospitals in Madrid (Spain). Inclusion criteria: male/female aged 12-19 years, newly diagnosed--or relapse of-- a malignant extracranial tumour; not having received any type of therapy--except surgery--at the time of diagnosis; adequate health status (Karnofsky/Eastern Cooperative Oncology Group scale score ≥50/≤2); to understand Spanish language and to provide written informed consent. The investigators will recruit ≥136 participants and conduct a randomised controlled trial. The intervention group will follow a supervised concurrent exercise program from the start to the end of intensive treatment. The exercise intervention will be performed in the hospital gymnasium or in the patients' ward (during neutropenic phases), and will also include supervised online sessions. Additionally, the intervention group will perform include inspiratory muscle training. The following outcomes will be assessed at baseline (diagnosis), end of treatment, and at 3-month follow-up in all participants: echocardiography-determined left ventricular function (primary outcome); and other echocardiography-determined variables, cardiac biomarkers, blood pressure, blood lipids, body composition, physical activity levels, energy intake, cardiorespiratory fitness, muscle strength, functional mobility, health-related quality of life, cancer-related fatigue, clinical variables, and potential biological underpinnings of exercise multisystemic benefits (metabolic and inflammatory markers, plasma proteome, gut microbiome, and immune function).Read full original descriptionShow less
Exercise Intervention for Adolescents With Cancer (EXERCADOL): A Randomized Controlled Trial
The investigators will study the effects of an supevised exercise intervention along the duration of intensive treatment (neoadjuvant [solid tumours]/intense chemotherapy [leukemias], expected median duration 5-6 months) on several health-related variables. Participants will be recruited from 4 hospitals in Madrid (Spain). Inclusion criteria: male/female aged 12-19 years, newly diagnosed--or relapse of-- a malignant extracranial tumour; not having received any type of therapy--except surgery--at the time of diagnosis; adequate health status (Karnofsky/Eastern Cooperative Oncology Group scale score ≥50/≤2); to understand Spanish language and to provide written informed consent. The investigators will recruit ≥136 participants and conduct a randomised controlled trial. The intervention group will follow a supervised concurrent exercise program from the start to the end of intensive treatment. The exercise intervention will be performed in the hospital gymnasium or in the patients' ward (during neutropenic phases), and will also include supervised online sessions. Additionally, the intervention group will perform include inspiratory muscle training. The following outcomes will be assessed at baseline (diagnosis), end of treatment, and at 3-month follow-up in all participants: echocardiography-determined left ventricular function (primary outcome); and other echocardiography-determined variables, cardiac biomarkers, blood pressure, blood lipids, body composition, physical activity levels, energy intake, cardiorespiratory fitness, muscle strength, functional mobility, health-related quality of life, cancer-related fatigue, clinical variables, and potential biological underpinnings of exercise multisystemic benefits (metabolic and inflammatory markers, plasma proteome, gut microbiome, and immune function).
Inclusion: Newly diagnosed with a malignant extracranial tumour; Not having received any therapy--except surgery--at diagnosis; Adequate health status (Karnofsky/Eastern Cooperative Oncology Group scale score ≥50/2); To understand Spanish language and provide written informed consent.
Exclusion: Comorbidity/acute condition contraindicating exercise practice; Life expectancy <3 months.