The Effect of Acute Exercise on Cardiac Autonomic, Cerebrovascular, and Cognitive Function in Spinal Cord Injury
Key facts
- Who runs it
- State University of New York at Buffalo
- Where
- Buffalo, United StatesSee the site
- Trial code
- Status
- Terminated
- People taking part
- 6 people enrolled
- Started
- 6 Sept 2022
- Ended
- 18 Dec 2024
- Type of study
- Interventional, 2 groupsOne group gets an existing treatment, for comparison.
- Treatments tested
- One bout of moderate-intensity sub-maximal aerobic exercise
- Record updated
- 6 March 2025
- Why it stopped
- We have enrolled all the required participants for this pilot study.
Who can take part
- Age
- 18 years to 55 years
- Sex
- Women and men
- Healthy volunteers
- Can take part
The registry criteria, word for word
Show all 14 criteriaShow less
Who can take part
- Spinal cord injury group:
- Males or females with chronic SCI (i.e. at least 6 months after the initial injury)
- International Standard for Neurological Classification of SCI (ISNCSCI) A-D
- Neurological level of injury C6 or below
- 18-55 years old
- Proficient in English
- Able to detect middle cerebral artery blood velocity (MCAv) and/or posterior cerebral artery blood velocity (PCAv) signals through TCD; Non-injured controls:
- Males or females without SCI
- 18-55 years old
- Proficient in English
- Able to detect MCAv and/or PCAv signals through TCD
Who cannot take part
- Cardiovascular, pulmonary or respiratory diseases, or diabetes mellitus, any other diseases/disorders affecting cardiac autonomic nervous system, such as glaucoma and attention deficit hyperactivity disorder (ADHD)
- Color Blindness
- Pregnancy
Where in United States
- Department of Rehabilitation Sciences at University at BuffaloBuffalo, United StatesNo longer taking part
About the trial
What the trial wants to find out
The aims of this proposal are to: 1) investigate whether individuals with spinal cord injury (SCI) demonstrate cardiac autonomic, cerebrovascular, and cognitive dysfunctions compared to non-injured age- and sex-matched controls in the following conditions: supine rest and head-up tilt/face-cooling test; 2) examine if autonomic completeness/ incompleteness, physical activity, and psychological distress are predictors for dysfunctions during supine rest and head-up tilt/face cooling conditions in SCI individuals; 3) examine if one bout of moderate-intensity aerobic exercise temporarily improves cardiac autonomic and cerebrovascular functions and thereby improves cognition when in supine rest and head- up tilt/face cooling conditions. The study will include an initial visit and an experimental visit to our lab. Three groups of participants will be included in this study: Group 1, SCI with acute exercise; group 2, SCI with rest-control; and group 3, age- and sex-matched non-injured individuals. Cardiovascular variables, such as heart rate variability, blood pressure variability, and cerebrovascular variables, such as cerebral blood flow velocity and oxygenated hemoglobin, and cognitive performance will be examined. The investigator hypothesizes that individuals with SCI will have impaired cardiac autonomic, cerebrovascular, and cognitive functions compared to the non-injured controls, and an acute exercise can improve those functions. Autonomic completeness/incompleteness, physical activity, and psychological distress are significant factors that predict cardiac autonomic, cerebrovascular, and cognitive functions in individuals with SCI.
The 2 groups in the trial
- CONExisting treatment, for comparison
Age-and sex-matched healthy controls with exercise intervention
Treatment: One bout of moderate-intensity sub-maximal aerobic exercise
- SCITreatment being tested
Individuals with spinal cord injury
Treatment: One bout of moderate-intensity sub-maximal aerobic exercise
Data and sources
- Registry record
- Listed on ClinicalTrials.gov.
- Official title
- The Effect of Acute Exercise on Cardiac Autonomic, Cerebrovascular, and Cognitive Function in Spinal Cord Injury: a Pilot Study
- Record updated
- 6 March 2025