Using lab and computer analysis to understand fatty liver disease linked to obesity

AI summary

From the trial's eligibility criteria. Machine-read from the registry text on this page, so it can be wrong. The registry text below and the trial team decide who can take part.

The trial is looking for adults with obesity who may also have fatty liver disease. Their samples and health data will be studied to build computer models.

Age

18 years or older

Sex

All sexes can join

Disease stage

Body mass index of 40 kg/m^2 or more, or between 35 and 40 kg/m^2 with high-risk conditions (high blood pressure, high blood fats, or type 2 diabetes)

Main reasons for not taking part

• Use of legal or illegal drugs, including alcohol
• Diagnosis of hepatitis
• Current cancer diagnosis or treatment
• Severe, terminal or infectious illness
• Chronic or acute inflammation

The registry criteria, word for word

What the trial wants to find out

The investigators seek to analyze the samples provided by patients with obesity-associated fatty liver disease at the multi-omics level and to integrate the results with clinical information, genotypic variants, and factors influencing inter-organ crosstalk. The main aim is to improve the interpretation of fatty liver disease associated with obesity and diabetes by developing predictive models built with algorithms from artificial intelligence. The challenge is to decipher the flow of information by exploring contributing factors, proximate causes of regulatory defects, and maladaptive responses that may promote therapeutic approaches.

The 3 groups in the trial

• Severe obesity without liver disease

  Patients with severe obesity who did not meet the criteria described in Kleiner et al. (2005) for nonalcoholic steatohepatitis diagnosis (score 0-2).

  Treatment: To propose diagnostic tests for liver diseases before surgical decisions.

• Severe obesity with liver disease without criteria for steatohepatitis

  Patients with severe obesity who did not meet the criteria described in Kleiner et al. (2005) for nonalcoholic steatohepatitis diagnosis, but their biopsies presented some liver severity (scores 3 and 4).

  Treatment: To propose diagnostic tests for liver diseases before surgical decisions.

• Severe obesity with well-defined steatohepatitis and/or cirrhosis

  Patients with severe obesity who met the criteria described in Kleiner et al. (2005) for nonalcoholic steatohepatitis diagnosis (score 5-8).

  Treatment: To propose diagnostic tests for liver diseases before surgical decisions.