Blood-brain barrier changes and thinking decline after stroke
Studies whether blood-brain barrier disruption at stroke predicts later thinking decline in adults.
Plain-language title generated from the registry record
Registry title: Global Blood-Brain Barrier Disruption and Post-Stroke Cognitive Decline
Key facts
- Where
- Baltimore, United StatesSee the site
Where in United States
- Johns Hopkins HospitalBaltimore, United StatesTaking people
Questions to ask the study team
- How often do I need to come in, and for how long each time?
- Are travel costs paid?
- Can I keep my own doctor?
- What happens if I want to stop?
Trial details
- Who runs it
- Johns Hopkins University
- Trial code
- NCT05556395
- Record updated
- 4 September 2026
- Original description
The goal of this study is to gain a better understanding of why some individuals who have suffered a stroke experience post-stroke cognitive decline. Specifically this study is testing whether global disruption of the blood-brain barrier detected at the time of the stroke is informative about the risk of post-stroke cognitive decline over the next 3 years.Read full original descriptionShow less
Global Blood-Brain Barrier Disruption and Post-Stroke Cognitive Decline
The goal of this study is to gain a better understanding of why some individuals who have suffered a stroke experience post-stroke cognitive decline. Specifically this study is testing whether global disruption of the blood-brain barrier detected at the time of the stroke is informative about the risk of post-stroke cognitive decline over the next 3 years.
Inclusion: Acute ischemic stroke demonstrated on an MRI scan that includes perfusion imaging with an exogenous contrast agent.
Exclusion: Inability to perform telephone-based cognitive assessments.