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Lung cancer screening scans for high-risk people in Taiwan

Studies low-dose CT lung scans in adults at high risk for lung cancer.

Key facts

Who runs it
Gee-Chen Chang
Where
Hsinchu, Hualien City, Kaohsiung City, New Taipei City, Taichung, and Taipei, TaiwanSee the 7 sites
Trial code
Registry title
Taiwan Real-world LDCT Screening Behavior and Outcome Research for High Risk Subjects Based on Health Promotion Administration
Status
Recruiting
People taking part
6,618 people, planned
Started
15 Dec 2022
Expected to end
31 Dec 2028
Type of study
Observational, 3 groups
Treatments tested
  • Low dose computed tomography
Record updated
10 September 2025

Who can take part

AI summary

From the trial's eligibility criteria. Machine-read from the registry text on this page, so it can be wrong. The registry text below and the trial team decide who can take part.

The trial is looking for people at high risk of lung cancer who can have a low-dose CT scan of the chest: former heavy smokers, close relatives of lung cancer patients, and people with high-risk work or home exposures.

Age
Group 1 and Group 3: 50 to 80 years. Group 2: older than 50, or younger than 50 but older than the age when the youngest affected relative was diagnosed.
Sex
All sexes can join.
Disease stage
No lung cancer. People must belong to one of three high-risk groups.
Earlier treatment
Former smokers (Group 1) must have quit smoking for more than 6 months but less than 15 years. People with past tuberculosis must have finished tuberculosis treatment more than 5 years before the study.

Main reasons for not taking part

  • Previous lung cancer
  • Another cancer within 5 years (except cervical carcinoma in situ or non-melanomatous skin cancer)
  • Chest CT scan within the last 18 months
  • Coughing up blood of unknown cause within one month
  • Weight loss of more than 6 kg (13 lb) within one year without a clear cause

The registry criteria, word for word

Show all 17 criteriaShow less

Who can take part

  • Group 1: Previous heavy smokers Age 50 to 80 years, meet both criteria in the followings
  • Cigarette smoking of at least 20 pack-years
  • With successful smoking cessation history (stopping smoking for more than 6 months), but less than 15 years; Group 2: First-degree relatives of lung cancer patients
  • aged more than 50 years
  • age less than 50 years old, but older than the age at diagnosis of the youngest lung cancer proband in the family; Group 3: With other high-risk occupational or environmental factors Age 50 to 80 years, meet one or more of the following criteria
  • air-pollution exposed occupations (such as traffic policemen, and street cleaners….) for at least 10 years
  • cooking index ≥ 110, defined as 2/7 * days cooking by pan frying, stir-frying, or deep frying in one week * years cooking
  • cooking without using ventilation for more than 20 years
  • history of pulmonary tuberculosis and complete anti-tuberculosis treatment with intervals more than 5 years before this study

Who cannot take part

  • previous history of lung cancer
  • another malignancy except for cervical carcinoma in situ or non-melanomatous carcinoma of the skin within 5 years
  • an inability to tolerate transthoracic procedures or thoracotomy
  • chest CT examination was performed within 18 months
  • hemoptysis of unknown etiology within one month
  • body weight loss of more than 6 kg within one year without an evident cause
  • a known pregnancy
  • Not capable of understanding or responding to the written questionnaire even through the help from the study team

Check if you might fit

Answer for yourself. This is not a decision: only the study team can say whether you can take part.

  • Are you between 20 and 80 years old?

Where in Taiwan

  • National Taiwan University Hospital Hsin Chu BranchHsinchu, TaiwanContact: Chong-Jen Yu, MD PhDTaking people
  • Hualien Tzu Chi HospitalHualien City, TaiwanContact: Chung-Ping Hsu, MD PhDTaking people
  • E-DA HospitalKaohsiung City, TaiwanContact: Yu-Feng Wei, MD PhDNot yet recruiting
  • Kaohsiung Medical University Chung-Ho Memorial HospitalKaohsiung City, TaiwanContact: Inn-Wen Chong, MD PhDTaking people
  • Ministry of Health and Welfare Shuang-Ho HospitalNew Taipei City, TaiwanContact: Po-Hao Feng, MD PhDNot yet recruiting
  • Chung Shan Medical UniversityTaichung, TaiwanContact: GEECHEN CHANG, MD, PhDTaking people
  • National Taiwan University HospitalTaipei, TaiwanContact: Chao-Chi Ho, MD PhDTaking people

About the trial

What the trial wants to find out

Lung cancer is the leading cause of mortality in the world, and also in Taiwan.Despite the researches and availability in new therapies, it causes the highest mortality and is one of the most preventable cancers as well. Smoking is the most common cause of lung cancer worldwide. Compared to lung cancer in smokers, lung cancer in never-smokers is associated with East Asian ethnicity, female sex, and adenocarcinoma histology. This unique risk group is likely to have distinct molecular drivers, especially EGFR, ALK, and ROS1 mutations.In National Taiwan Cancer Registry data, more than half (53%) of all newly diagnosed lung cancer patients and 93% of female patients are lifelong never-smokers. This scenario is common in East Asia. It is essential to develop a different strategy for screening lung cancer patients with other high-risk profiles. Several risk factors have been identified in never-smoking lung cancer and one of the most important factor is a lung cancer family history (LCFH) in a first-degree relative. Other high-risk occupational or environmental factors include air-pollution exposed occupations (such as traffic policeman and street cleaners) for at least 10 years, cooking index ≥ 110, defined as 2/7 * days cooking by pan frying, stir frying, or deep frying in one week * years cooking, cooking without using ventilation, passive smoke exposure, and history of pulmonary tuberculosis or chronic obstructive pulmonary disorders.

Read full original descriptionShow less

As described above, three high risk groups are interested in this study, the previous heavy smokers (group 1); those who has family history (group 2) and those who have high risk occupation or environment factors (group 3). From the published researches, we assume the detection rate to be 1.1% for group 1 based on NLST results16, 2.6% for group 2 (395 out of 12,011 subjects in TALENT), and we assume the detection Group 3 to be 1% after consulting board-certified senior specialists in this field.

This is a prospective, multi-center, single arm study in Taiwan of subjects who are eligible to receive LDCT screening based on recommendation of Health Promotion Administration of Taiwan.

The primary objective of TRIO part A is the LDCT screening acceptance rate of high lung cancer risk subjects.

The primary objective of TRIO part B is the exact lung cancer detection rates in these three groups.

Other secondary objectives are also included.

The 3 groups in the trial

  • Previous heavy smokers

    Age 40 to 80 years who have at least a 20-pack-year smoking history with successful smoking cessation history (stopping smoking for more than 6 months), but less than 15 years

    Treatment: Low dose computed tomography

  • First degree relatives of lung cancer patients

    First-degree relatives of lung cancer patients 1. aged more than 40 years 2. age less than 40 years old, but older than the age at diagnosis of the youngest lung cancer proband in the family

    Treatment: Low dose computed tomography

  • With other high-risk occupational or environmental factors

    Age 40 to 80 years, meet one or more of the following criteria. 1. air-pollution exposed occupations (such as traffic policeman, street cleaners….) for at least 10 years 2. cooking index ≥ 110, defined as 2/7 \* days cooking by pan frying, stir frying, or deep frying in one week \* years cooking. 3. cooking without using ventilation for more than 20 years 4. history of pulmonary tuberculosis and complete anti-tuberculosis treatment with interval more than 5 years before this study

    Treatment: Low dose computed tomography

Questions to ask the study team

  1. How often do I need to come in, and for how long each time?
  2. Are travel costs paid?
  3. Can I keep my own doctor?
  4. What happens if I want to stop?

Contact the study team: see the registry record → Contacts and Locations

Print a page for my doctor

Data and sources

Registry record
Listed on ClinicalTrials.gov.
Official title
Taiwan Real-world Low-dose Computed Tomography Screening behavIor and Outcome Research for High Risk Subjects Based on Health Promotion Administration-part A: Questionnaire Survey -Part B: LDCT Screening Outcome and Management
Plain-language title
Lung cancer screening scans for high-risk people in TaiwanGenerated from the registry record. The registry title is the official one.
AI summary
From the trial's eligibility criteria. Read by machine on 12 November 2026.
Fit questions
Built from NCT05557487, who can take part
Record updated
10 September 2025