Comparing Combinations of Drugs to Treat Newly Diagnosed Multiple Myeloma (NDMM) When a Stem Cell Transplant is Not a Medically Suitable Treatment
Key facts
- Where
- Aberdeen, Aitkin, Albuquerque, Allentown, Alton, Anchorage, Ankeny, Ann Arbor, Antigo, Appleton, Arroyo Grande, Ashland, Aurora, Ballwin, Baltimore, Bardstown, Battle Creek, Baxter, Beavercreek, Bellingham, Bemidji, Bend, Bethlehem, Bettendorf, Bismarck, Bloomington, Boardman, Boiling Springs, Boise, Bolivar, Brainerd, Branson, Bremerton, Brighton, Burbank, Burnsville, Burr Ridge, Cambridge, Cameron Park, Canton, Cape Girardeau, Carbondale, Carmel, Carmichael, Caro, Carterville, Carthage, Cedar Rapids, Centerville, Centralia, Charleston, Chelsea, Chippewa Falls, Cincinnati, Clackamas, Clarkston, Clive, Colorado Springs, Conroe, Coon Rapids, Coos Bay, Corbin, Council Bluffs, Creston, Crown Point, Danville, Dayton, Decatur, Deer River, Denver, Derby, Des Moines, Detroit, Detroit Lakes, Dixon, Duluth, Durango, Dyer, Easley, East China, East Stroudsburg, Eau Claire, Edina, Edmonds, Effingham, Elk Grove, Ely, Eureka, Everett, Exeter, Fairfield, Fargo, Farmington, Findlay, Flint, Fort Lauderdale, Fort Smith, Fosston, Franklin, Fridley, Fruitland, Galesburg, Garden City, Glastonbury, Grand Rapids, Great Bend, Greenville, Greenwich, Greer, Grosse Pointe Woods, Guilford, Hartford, Hayward, Hazleton, Hibbing, Hines, Hobart, Homer Glen, Houston, Indianapolis, International Falls, Iowa City, Issaquah, Jacksonville, Jamestown, Jefferson City, Joplin, Jupiter, Kalamazoo, Kansas City, Kearney, Kennewick, Kettering, Kewanee, La Crosse, Lacey, Ladysmith, Lakewood, Lansing, League City, Lewisburg, Lexington, Lincoln, Little Rock, Littleton, Livonia, London, Longmont, Longview, Macomb, Maple Grove, Maplewood, Marlette, Marshfield, Martinsville, Marysville, Mattoon, Maywood, Medford, Melrose Park, Merced, Meridian, Minneapolis, Minocqua, Missoula, Monticello, Moose Lake, Mount Sterling, Mount Vernon, Munster, Muskegon, Nampa, Napa, Neillsville, New Haven, New Richmond, New Ulm, New York, Newberg, Niles, North Haven, Norton Shores, O'Fallon, Oklahoma City, Omaha, Oregon City, Osage Beach, Ottawa, Papillion, Park Rapids, Parker, Pekin, Peoria, Peru, Phoenix, Pontiac, Portland, Princeton, Pueblo, Redmond, Reed City, Rhinelander, Rice Lake, Richmond, Rio Rancho, Robbinsdale, Rochester, Rocklin, Rolla, Sacramento, Saginaw, Saint Joseph, Saint Louis Park, Saint Paul, Sainte Genevieve, San Antonio, San Luis Obispo, Sandstone, Santa Maria, Santa Rosa, Scranton, Seattle, Sedro-Woolley, Seneca, Shakopee, Shelton, Sioux Falls, South Hill, Spooner, Springfield, St Louis, Stamford, Sterling Heights, Stevens Point, Stillwater, Sugar Land, Sullivan, Sunset Hills, Superior, Tawas City, Thief River Falls, Torrington, Traverse City, Troy, Truckee, Trumbull, Twin Falls, Urbana, Valparaiso, Vancouver, Virginia, Waconia, Walla Walla, Warren, Washington, Waterbury, Waterford, Wausau, West Branch, West Des Moines, Westerly, Weston, Wilkes-Barre, Willmar, Wisconsin Rapids, Woodbury, Woodland, Worthington, Wyoming, Yankton, Yelm, Yorkville, Youngstown, and Ypsilanti, United StatesSee the 397 sites
- Phase
- Phase 3
Where in United States
- Avera Cancer Institute-AberdeenAberdeen, United StatesTaking people
- Providence Regional Cancer System-AberdeenAberdeen, United StatesTaking people
- Riverwood Healthcare CenterAitkin, United StatesTaking people
- Lovelace Medical Center-Saint Joseph SquareAlbuquerque, United StatesTaking people
- Presbyterian Kaseman HospitalAlbuquerque, United StatesTaking people
- University of New Mexico Cancer CenterAlbuquerque, United StatesTaking people
- Lehigh Valley Hospital-Cedar CrestAllentown, United StatesTaking people
- Saint Anthony's HealthAlton, United StatesTaking people
- Alaska Breast Care and Surgery LLCAnchorage, United StatesTaking people
- Alaska Oncology and Hematology LLCAnchorage, United StatesTaking people
- Alaska Women's Cancer CareAnchorage, United StatesTaking people
- Anchorage Associates in Radiation MedicineAnchorage, United StatesTaking people
- Anchorage Oncology CentreAnchorage, United StatesTaking people
- Anchorage Radiation Therapy CenterAnchorage, United StatesTaking people
- Katmai Oncology GroupAnchorage, United StatesTaking people
- Providence Alaska Medical CenterAnchorage, United StatesTaking people
- Mission Cancer and Blood - AnkenyAnkeny, United StatesTaking people
- Saint Joseph Mercy HospitalAnn Arbor, United StatesTaking people
- Langlade Hospital and Cancer CenterAntigo, United StatesTaking people
- ThedaCare Regional Cancer CenterAppleton, United StatesTaking people
- Mission Hope Medical Oncology - Arroyo GrandeArroyo Grande, United StatesTaking people
- Duluth Clinic AshlandAshland, United StatesTaking people
- Northwest Wisconsin Cancer CenterAshland, United StatesTaking people
- Rocky Mountain Regional VA Medical CenterAurora, United StatesTaking people
- Rush-Copley Medical CenterAurora, United StatesTaking people
- Saint Louis Cancer and Breast Institute-BallwinBallwin, United StatesTaking people
- Greater Baltimore Medical CenterBaltimore, United StatesTaking people
- Flaget Memorial HospitalBardstown, United StatesTaking people
- Bronson Battle CreekBattle Creek, United StatesTaking people
- Essentia Health - Baxter ClinicBaxter, United StatesTaking people
- Indu and Raj Soin Medical CenterBeavercreek, United StatesTaking people
- PeaceHealth Saint Joseph Medical CenterBellingham, United StatesTaking people
- Sanford Joe Lueken Cancer CenterBemidji, United StatesTaking people
- Saint Charles Health SystemBend, United StatesTaking people
- Lehigh Valley Hospital - MuhlenbergBethlehem, United StatesTaking people
- University of Iowa Healthcare Cancer Services Quad CitiesBettendorf, United StatesTaking people
- Sanford Bismarck Medical CenterBismarck, United StatesTaking people
- Illinois CancerCare-BloomingtonBloomington, United StatesTaking people
- Saint Joseph Medical CenterBloomington, United StatesTaking people
- Saint Elizabeth Boardman HospitalBoardman, United StatesTaking people
- Prisma Health Cancer Institute - SpartanburgBoiling Springs, United StatesTaking people
- Saint Luke's Cancer Institute - BoiseBoise, United StatesTaking people
- Central Care Cancer Center - BolivarBolivar, United StatesTaking people
- Essentia Health Saint Joseph's Medical CenterBrainerd, United StatesTaking people
- Cox Cancer Center BransonBranson, United StatesTaking people
- Harrison Medical CenterBremerton, United StatesTaking people
- Saint Joseph Mercy BrightonBrighton, United StatesTaking people
- Trinity Health IHA Medical Group Hematology Oncology - BrightonBrighton, United StatesTaking people
- Providence Saint Joseph Medical Center/Disney Family Cancer CenterBurbank, United StatesTaking people
- Minnesota Oncology - BurnsvilleBurnsville, United StatesTaking people
- Loyola Center for Health at Burr RidgeBurr Ridge, United StatesTaking people
- Cambridge Medical CenterCambridge, United StatesTaking people
- Marshall Cancer CenterCameron Park, United StatesTaking people
- Illinois CancerCare-CantonCanton, United StatesTaking people
- Saint Joseph Mercy CantonCanton, United StatesTaking people
- Trinity Health IHA Medical Group Hematology Oncology - CantonCanton, United StatesTaking people
- Saint Francis Medical CenterCape Girardeau, United StatesTaking people
- Southeast Cancer CenterCape Girardeau, United StatesTaking people
- Memorial Hospital of CarbondaleCarbondale, United StatesTaking people
- IU Health North HospitalCarmel, United StatesTaking people
- Mercy Cancer Center - CarmichaelCarmichael, United StatesTaking people
- Mercy San Juan Medical CenterCarmichael, United StatesTaking people
- Caro Cancer CenterCaro, United StatesTaking people
- SIH Cancer InstituteCarterville, United StatesTaking people
- Illinois CancerCare-CarthageCarthage, United StatesTaking people
- Physicians' Clinic of Iowa PCCedar Rapids, United StatesTaking people
- Dayton Physicians LLC-Miami Valley SouthCenterville, United StatesTaking people
- Centralia Oncology ClinicCentralia, United StatesTaking people
- Providence Regional Cancer System-CentraliaCentralia, United StatesTaking people
- Saint Mary's HospitalCentralia, United StatesTaking people
- West Virginia University Charleston DivisionCharleston, United StatesTaking people
- Saint Joseph Mercy ChelseaChelsea, United StatesTaking people
- Trinity Health IHA Medical Group Hematology Oncology - Chelsea HospitalChelsea, United StatesTaking people
- Marshfield Clinic-Chippewa CenterChippewa Falls, United StatesTaking people
- Bethesda North HospitalCincinnati, United StatesTaking people
- Good Samaritan Hospital - CincinnatiCincinnati, United StatesTaking people
- Oncology Hematology Care Inc-KenwoodCincinnati, United StatesTaking people
- TriHealth Cancer Institute-AndersonCincinnati, United StatesTaking people
- TriHealth Cancer Institute-WestsideCincinnati, United StatesTaking people
- Clackamas Radiation Oncology CenterClackamas, United StatesTaking people
- Providence Cancer Institute Clackamas ClinicClackamas, United StatesTaking people
- Hematology Oncology Consultants-ClarkstonClarkston, United StatesTaking people
- Newland Medical Associates-ClarkstonClarkston, United StatesTaking people
- Medical Oncology and Hematology Associates-West Des MoinesClive, United StatesTaking people
- Mercy Cancer Center-West LakesClive, United StatesTaking people
- Penrose-Saint Francis HealthcareColorado Springs, United StatesTaking people
- Rocky Mountain Cancer Centers-PenroseColorado Springs, United StatesTaking people
- Saint Francis Cancer CenterColorado Springs, United StatesTaking people
- MD Anderson in The WoodlandsConroe, United StatesTaking people
- Mercy HospitalCoon Rapids, United StatesTaking people
- Bay Area HospitalCoos Bay, United StatesTaking people
- Commonwealth Cancer Center-CorbinCorbin, United StatesTaking people
- Alegent Health Mercy HospitalCouncil Bluffs, United StatesNo longer taking part
- Greater Regional Medical CenterCreston, United StatesTaking people
- Northwest Cancer Center - Main CampusCrown Point, United StatesTaking people
- Carle at The RiverfrontDanville, United StatesTaking people
- Geisinger Medical CenterDanville, United StatesTaking people
- Dayton Physician LLC-Miami Valley Hospital NorthDayton, United StatesTaking people
- Cancer Care Specialists of Illinois - DecaturDecatur, United StatesTaking people
- Decatur Memorial HospitalDecatur, United StatesTaking people
- Essentia Health - Deer River ClinicDeer River, United StatesTaking people
- Porter Adventist HospitalDenver, United StatesNo longer taking part
- Smilow Cancer Hospital-Derby Care CenterDerby, United StatesTaking people
- Mercy Medical Center - Des MoinesDes Moines, United StatesTaking people
- Mission Cancer and Blood - LaurelDes Moines, United StatesTaking people
- Ascension Saint John HospitalDetroit, United StatesTaking people
- Essentia Health Saint Mary's - Detroit Lakes ClinicDetroit Lakes, United StatesTaking people
- Illinois CancerCare-DixonDixon, United StatesTaking people
- Essentia Health Cancer CenterDuluth, United StatesTaking people
- Essentia Health Saint Mary's Medical CenterDuluth, United StatesTaking people
- Miller-Dwan HospitalDuluth, United StatesTaking people
- Mercy Medical CenterDurango, United StatesTaking people
- Southwest Oncology PCDurango, United StatesTaking people
- Northwest Oncology LLCDyer, United StatesTaking people
- Prisma Health Cancer Institute - EasleyEasley, United StatesTaking people
- Great Lakes Cancer Management Specialists-Doctors ParkEast China, United StatesTaking people
- Pocono Medical CenterEast Stroudsburg, United StatesTaking people
- Marshfield Medical Center-EC Cancer CenterEau Claire, United StatesTaking people
- Fairview Southdale HospitalEdina, United StatesTaking people
- Swedish Cancer Institute-EdmondsEdmonds, United StatesTaking people
- Carle Physician Group-EffinghamEffingham, United StatesTaking people
- Crossroads Cancer CenterEffingham, United StatesTaking people
- Mercy Cancer Center - Elk GroveElk Grove, United StatesTaking people
- Essentia Health - Ely ClinicEly, United StatesTaking people
- Illinois CancerCare-EurekaEureka, United StatesTaking people
- Providence Regional Cancer PartnershipEverett, United StatesTaking people
- Exeter HospitalExeter, United StatesTaking people
- Smilow Cancer Hospital Care Center-FairfieldFairfield, United StatesTaking people
- Essentia Health Cancer Center-South University ClinicFargo, United StatesTaking people
- Sanford Broadway Medical CenterFargo, United StatesTaking people
- Sanford Medical Center FargoFargo, United StatesTaking people
- Sanford Roger Maris Cancer CenterFargo, United StatesTaking people
- Sanford South University Medical CenterFargo, United StatesTaking people
- Southpointe-Sanford Medical Center FargoFargo, United StatesTaking people
- Parkland Health Center - FarmingtonFarmington, United StatesTaking people
- Armes Family Cancer CenterFindlay, United StatesTaking people
- Blanchard Valley HospitalFindlay, United StatesTaking people
- Orion Cancer CareFindlay, United StatesTaking people
- Genesee Cancer and Blood Disease Treatment CenterFlint, United StatesTaking people
- Genesee Hematology Oncology PCFlint, United StatesTaking people
- Genesys Hurley Cancer InstituteFlint, United StatesTaking people
- Hurley Medical CenterFlint, United StatesTaking people
- Holy Cross HospitalFort Lauderdale, United StatesTaking people
- Mercy Hospital Fort SmithFort Smith, United StatesTaking people
- Essentia Health - FosstonFosston, United StatesTaking people
- Dayton Physicians LLC-AtriumFranklin, United StatesTaking people
- Unity HospitalFridley, United StatesNo longer taking part
- Saint Luke's Cancer Institute - FruitlandFruitland, United StatesTaking people
- Illinois CancerCare-GalesburgGalesburg, United StatesTaking people
- Western Illinois Cancer Treatment CenterGalesburg, United StatesTaking people
- Central Care Cancer Center - Garden CityGarden City, United StatesTaking people
- Smilow Cancer Hospital Care Center at GlastonburyGlastonbury, United StatesTaking people
- Helen DeVos Children's Hospital at Spectrum HealthGrand Rapids, United StatesTaking people
- Spectrum Health at Butterworth CampusGrand Rapids, United StatesTaking people
- Trinity Health Grand Rapids HospitalGrand Rapids, United StatesTaking people
- Central Care Cancer Center - Great BendGreat Bend, United StatesTaking people
- Dayton Physicians LLC-WayneGreenville, United StatesTaking people
- Prisma Health Cancer Institute - ButternutGreenville, United StatesTaking people
- Prisma Health Cancer Institute - EastsideGreenville, United StatesTaking people
- Prisma Health Cancer Institute - FarisGreenville, United StatesTaking people
- Wayne HospitalGreenville, United StatesTaking people
- Smilow Cancer Hospital Care Center at GreenwichGreenwich, United StatesTaking people
- Prisma Health Cancer Institute - GreerGreer, United StatesTaking people
- Academic Hematology Oncology SpecialistsGrosse Pointe Woods, United StatesTaking people
- Great Lakes Cancer Management Specialists-Van Elslander Cancer CenterGrosse Pointe Woods, United StatesTaking people
- Smilow Cancer Hospital Care Center - GuilfordGuilford, United StatesTaking people
- Smilow Cancer Hospital Care Center at Saint FrancisHartford, United StatesTaking people
- Essentia Health-Hayward ClinicHayward, United StatesTaking people
- Lehigh Valley Hospital-HazletonHazleton, United StatesTaking people
- Essentia Health Hibbing ClinicHibbing, United StatesTaking people
- Edward Hines Jr VA HospitalHines, United StatesTaking people
- Northwest Cancer Center - HobartHobart, United StatesTaking people
- Saint Mary Medical CenterHobart, United StatesTaking people
- Loyola Medicine Homer GlenHomer Glen, United StatesTaking people
- Baylor College of Medicine/Dan L Duncan Comprehensive Cancer CenterHouston, United StatesTaking people
- Ben Taub General HospitalHouston, United StatesTaking people
- M D Anderson Cancer CenterHouston, United StatesTaking people
- MD Anderson West HoustonHouston, United StatesTaking people
- Michael E. DeBakey VA Medical CenterHouston, United StatesTaking people
- Indiana University/Melvin and Bren Simon Cancer CenterIndianapolis, United StatesTaking people
- Saint Catherine HospitalIndianapolis, United StatesTaking people
- Essentia Health - International Falls ClinicInternational Falls, United StatesTaking people
- University of Iowa/Holden Comprehensive Cancer CenterIowa City, United StatesTaking people
- Swedish Cancer Institute-IssaquahIssaquah, United StatesTaking people
- Mayo Clinic in FloridaJacksonville, United StatesTaking people
- Essentia Health - Jamestown ClinicJamestown, United StatesTaking people
- Capital Region Southwest CampusJefferson City, United StatesTaking people
- Freeman Health SystemJoplin, United StatesTaking people
- Mercy Hospital JoplinJoplin, United StatesTaking people
- Jupiter Medical CenterJupiter, United StatesTaking people
- Ascension Borgess Cancer CenterKalamazoo, United StatesTaking people
- Borgess Medical CenterKalamazoo, United StatesTaking people
- Bronson Methodist HospitalKalamazoo, United StatesTaking people
- West Michigan Cancer CenterKalamazoo, United StatesTaking people
- Research Medical CenterKansas City, United StatesTaking people
- CHI Health Good SamaritanKearney, United StatesTaking people
- Kadlec Clinic Hematology and OncologyKennewick, United StatesTaking people
- Greater Dayton Cancer CenterKettering, United StatesTaking people
- Kettering Medical CenterKettering, United StatesTaking people
- Illinois CancerCare-Kewanee ClinicKewanee, United StatesTaking people
- Gundersen Lutheran Medical CenterLa Crosse, United StatesTaking people
- Providence Regional Cancer System-LaceyLacey, United StatesTaking people
- Marshfield Clinic - Ladysmith CenterLadysmith, United StatesTaking people
- Saint Anthony HospitalLakewood, United StatesTaking people
- University of Michigan Health - Sparrow LansingLansing, United StatesTaking people
- MD Anderson League CityLeague City, United StatesTaking people
- Geisinger Medical Oncology-LewisburgLewisburg, United StatesTaking people
- Saint Joseph HospitalLexington, United StatesTaking people
- Saint Joseph Hospital EastLexington, United StatesTaking people
- Saint Joseph Radiation Oncology Resource CenterLexington, United StatesTaking people
- Saint Elizabeth Regional Medical CenterLincoln, United StatesNo longer taking part
- CARTI Cancer CenterLittle Rock, United StatesTaking people
- University of Arkansas for Medical SciencesLittle Rock, United StatesTaking people
- John L McClellan Memorial Veterans HospitalLittle Rock, United StatesNo longer taking part
- Littleton Adventist HospitalLittleton, United StatesNo longer taking part
- Trinity Health Saint Mary Mercy Livonia HospitalLivonia, United StatesTaking people
- Saint Joseph LondonLondon, United StatesTaking people
- Longmont United HospitalLongmont, United StatesTaking people
- PeaceHealth Saint John Medical CenterLongview, United StatesTaking people
- Great Lakes Cancer Management Specialists-Macomb Medical CampusMacomb, United StatesTaking people
- Illinois CancerCare-MacombMacomb, United StatesTaking people
- Fairview Clinics and Surgery Center Maple GroveMaple Grove, United StatesTaking people
- Minnesota Oncology Hematology PA-MaplewoodMaplewood, United StatesTaking people
- Saint John's Hospital - HealtheastMaplewood, United StatesTaking people
- Saint Mary's Oncology/Hematology Associates of MarletteMarlette, United StatesTaking people
- Marshfield Medical Center-MarshfieldMarshfield, United StatesTaking people
- Sovah Health MartinsvilleMartinsville, United StatesTaking people
- Fremont - Rideout Cancer CenterMarysville, United StatesTaking people
- Carle Physician Group-Mattoon/CharlestonMattoon, United StatesTaking people
- Loyola University Medical CenterMaywood, United StatesTaking people
- Aspirus Medford HospitalMedford, United StatesTaking people
- Rogue Valley Medical CenterMedford, United StatesTaking people
- Marjorie Weinberg Cancer Center at Loyola-GottliebMelrose Park, United StatesTaking people
- Mercy UC Davis Cancer CenterMerced, United StatesTaking people
- Saint Luke's Cancer Institute - MeridianMeridian, United StatesTaking people
- Abbott-Northwestern HospitalMinneapolis, United StatesTaking people
- Health Partners IncMinneapolis, United StatesTaking people
- Hennepin County Medical CenterMinneapolis, United StatesTaking people
- Marshfield Clinic-Minocqua CenterMinocqua, United StatesTaking people
- Saint Patrick Hospital - Community HospitalMissoula, United StatesTaking people
- Monticello Cancer CenterMonticello, United StatesTaking people
- Essentia Health - Moose Lake ClinicMoose Lake, United StatesTaking people
- Saint Joseph Mount SterlingMount Sterling, United StatesTaking people
- Good Samaritan Regional Health CenterMount Vernon, United StatesTaking people
- The Community HospitalMunster, United StatesTaking people
- Women's Diagnostic Center - MunsterMunster, United StatesTaking people
- Trinity Health Muskegon HospitalMuskegon, United StatesTaking people
- Saint Luke's Cancer Institute - NampaNampa, United StatesTaking people
- Providence Queen of The ValleyNapa, United StatesTaking people
- Marshfield Medical Center - NeillsvilleNeillsville, United StatesTaking people
- Smilow Cancer Center/Yale-New Haven HospitalNew Haven, United StatesTaking people
- Yale UniversityNew Haven, United StatesTaking people
- Cancer Center of Western WisconsinNew Richmond, United StatesTaking people
- New Ulm Medical CenterNew Ulm, United StatesTaking people
- NYP/Columbia University Medical Center/Herbert Irving Comprehensive Cancer CenterNew York, United StatesTaking people
- Providence Newberg Medical CenterNewberg, United StatesTaking people
- Corewell Health Lakeland Hospitals - Niles HospitalNiles, United StatesTaking people
- Yale-New Haven Hospital North Haven Medical CenterNorth Haven, United StatesTaking people
- Cancer and Hematology Centers of Western Michigan - Norton ShoresNorton Shores, United StatesTaking people
- Cancer Care Center of O'FallonO'Fallon, United StatesTaking people
- HSHS Saint Elizabeth's HospitalO'Fallon, United StatesTaking people
- Mercy Hospital Oklahoma CityOklahoma City, United StatesTaking people
- University of Oklahoma Health Sciences CenterOklahoma City, United StatesNot yet recruiting
- Alegent Health Bergan Mercy Medical CenterOmaha, United StatesTaking people
- Alegent Health Immanuel Medical CenterOmaha, United StatesTaking people
- Alegent Health Lakeside HospitalOmaha, United StatesTaking people
- Creighton University Medical CenterOmaha, United StatesTaking people
- Providence Willamette Falls Medical CenterOregon City, United StatesTaking people
- Lake Regional HospitalOsage Beach, United StatesTaking people
- Illinois CancerCare-Ottawa ClinicOttawa, United StatesTaking people
- Midlands Community HospitalPapillion, United StatesNo longer taking part
- Essentia Health - Park RapidsPark Rapids, United StatesTaking people
- Parker Adventist HospitalParker, United StatesNo longer taking part
- Illinois CancerCare-PekinPekin, United StatesTaking people
- Illinois CancerCare-PeoriaPeoria, United StatesTaking people
- Methodist Medical Center of IllinoisPeoria, United StatesTaking people
- Illinois CancerCare-PeruPeru, United StatesTaking people
- Valley Radiation OncologyPeru, United StatesTaking people
- Cancer Center at Saint Joseph'sPhoenix, United StatesTaking people
- 21st Century Oncology-PontiacPontiac, United StatesTaking people
- Hope Cancer CenterPontiac, United StatesTaking people
- Newland Medical Associates-PontiacPontiac, United StatesTaking people
- Saint Joseph Mercy OaklandPontiac, United StatesTaking people
- Providence Portland Medical CenterPortland, United StatesTaking people
- Providence Saint Vincent Medical CenterPortland, United StatesTaking people
- Fairview Northland Medical CenterPrinceton, United StatesTaking people
- Illinois CancerCare-PrincetonPrinceton, United StatesTaking people
- Saint Mary Corwin Medical CenterPueblo, United StatesTaking people
- Saint Charles Health System-RedmondRedmond, United StatesTaking people
- Corewell Health Reed City HospitalReed City, United StatesTaking people
- Ascension Saint Mary's HospitalRhinelander, United StatesTaking people
- Marshfield Medical Center-Rice LakeRice Lake, United StatesTaking people
- Reid HealthRichmond, United StatesTaking people
- VCU Massey Cancer Center at Stony PointRichmond, United StatesTaking people
- Virginia Cancer InstituteRichmond, United StatesTaking people
- Virginia Commonwealth University/Massey Cancer CenterRichmond, United StatesTaking people
- Presbyterian Rust Medical Center/Jorgensen Cancer CenterRio Rancho, United StatesTaking people
- North Memorial Medical Health CenterRobbinsdale, United StatesTaking people
- Mayo Clinic in RochesterRochester, United StatesTaking people
- University of RochesterRochester, United StatesTaking people
- Mercy Cancer Center - RocklinRocklin, United StatesTaking people
- Delbert Day Cancer Institute at PCRMCRolla, United StatesTaking people
- Mercy Clinic-Rolla-Cancer and HematologyRolla, United StatesTaking people
- Mercy Cancer Center - SacramentoSacramento, United StatesTaking people
- University of California Davis Comprehensive Cancer CenterSacramento, United StatesTaking people
- Ascension Saint Mary's HospitalSaginaw, United StatesTaking people
- Oncology Hematology Associates of Saginaw Valley PCSaginaw, United StatesTaking people
- Corewell Health Lakeland Hospitals - Marie Yeager Cancer CenterSaint Joseph, United StatesTaking people
- Heartland Regional Medical CenterSaint Joseph, United StatesTaking people
- Lakeland Medical Center Saint JosephSaint Joseph, United StatesTaking people
- Park Nicollet Clinic - Saint Louis ParkSaint Louis Park, United StatesTaking people
- Regions HospitalSaint Paul, United StatesTaking people
- United HospitalSaint Paul, United StatesTaking people
- Sainte Genevieve County Memorial HospitalSainte Genevieve, United StatesTaking people
- University of Texas Health Science Center at San AntonioSan Antonio, United StatesTaking people
- Pacific Central Coast Health Center-San Luis ObispoSan Luis Obispo, United StatesTaking people
- Essentia Health SandstoneSandstone, United StatesTaking people
- Mission Hope Medical Oncology - Santa MariaSanta Maria, United StatesTaking people
- Providence Medical Foundation - Santa RosaSanta Rosa, United StatesTaking people
- Providence Santa Rosa Memorial HospitalSanta Rosa, United StatesTaking people
- Community Medical CenterScranton, United StatesTaking people
- Swedish Medical Center-Ballard CampusSeattle, United StatesTaking people
- Swedish Medical Center-Cherry HillSeattle, United StatesTaking people
- Swedish Medical Center-First HillSeattle, United StatesTaking people
- PeaceHealth United General Medical CenterSedro-Woolley, United StatesTaking people
- Prisma Health Cancer Institute - SenecaSeneca, United StatesTaking people
- Saint Francis Regional Medical CenterShakopee, United StatesTaking people
- Providence Regional Cancer System-SheltonShelton, United StatesTaking people
- Avera Cancer InstituteSioux Falls, United StatesTaking people
- Sanford Cancer Center Oncology ClinicSioux Falls, United StatesTaking people
- Sanford USD Medical Center - Sioux FallsSioux Falls, United StatesTaking people
- VCU Community Memorial Health CenterSouth Hill, United StatesTaking people
- Essentia Health-Spooner ClinicSpooner, United StatesTaking people
- CoxHealth South HospitalSpringfield, United StatesTaking people
- Memorial Medical CenterSpringfield, United StatesTaking people
- Mercy Hospital SpringfieldSpringfield, United StatesTaking people
- Southern Illinois University School of MedicineSpringfield, United StatesTaking people
- Springfield ClinicSpringfield, United StatesTaking people
- Mercy Hospital Saint LouisSt Louis, United StatesTaking people
- Mercy Hospital SouthSt Louis, United StatesTaking people
- Missouri Baptist Medical CenterSt Louis, United StatesTaking people
- Saint Louis Cancer and Breast Institute-South CitySt Louis, United StatesTaking people
- Smilow Cancer Hospital Care Center at Long RidgeStamford, United StatesTaking people
- Bhadresh Nayak MD PC-Sterling HeightsSterling Heights, United StatesTaking people
- Ascension Saint Michael's HospitalStevens Point, United StatesTaking people
- Marshfield Medical Center-River Region at Stevens PointStevens Point, United StatesTaking people
- Lakeview HospitalStillwater, United StatesTaking people
- MD Anderson in Sugar LandSugar Land, United StatesTaking people
- Missouri Baptist Sullivan HospitalSullivan, United StatesTaking people
- BJC Outpatient Center at Sunset HillsSunset Hills, United StatesTaking people
- Essentia Health Saint Mary's Hospital - SuperiorSuperior, United StatesTaking people
- Ascension Saint Joseph HospitalTawas City, United StatesTaking people
- Sanford Thief River Falls Medical CenterThief River Falls, United StatesTaking people
- Smilow Cancer Hospital-Torrington Care CenterTorrington, United StatesTaking people
- Munson Medical CenterTraverse City, United StatesTaking people
- Dayton Physicians LLC - TroyTroy, United StatesTaking people
- Gene Upshaw Memorial Tahoe Forest Cancer CenterTruckee, United StatesTaking people
- Smilow Cancer Hospital Care Center-TrumbullTrumbull, United StatesTaking people
- Saint Luke's Cancer Institute - Twin FallsTwin Falls, United StatesTaking people
- Carle Cancer CenterUrbana, United StatesTaking people
- The Carle Foundation HospitalUrbana, United StatesTaking people
- Northwest Cancer Center - ValparaisoValparaiso, United StatesTaking people
- PeaceHealth Southwest Medical CenterVancouver, United StatesTaking people
- Essentia Health Virginia ClinicVirginia, United StatesTaking people
- Ridgeview Medical CenterWaconia, United StatesTaking people
- Providence Saint Mary Regional Cancer CenterWalla Walla, United StatesTaking people
- Advanced Breast Care Center PLLCWarren, United StatesTaking people
- Great Lakes Cancer Management Specialists-Macomb Professional BuildingWarren, United StatesTaking people
- Macomb Hematology Oncology PCWarren, United StatesTaking people
- Michigan Breast Specialists-WarrenWarren, United StatesTaking people
- Saint John Macomb-Oakland HospitalWarren, United StatesTaking people
- Saint Joseph Warren HospitalWarren, United StatesTaking people
- Illinois CancerCare - WashingtonWashington, United StatesTaking people
- Mercy Hospital WashingtonWashington, United StatesTaking people
- Smilow Cancer Hospital-Waterbury Care CenterWaterbury, United StatesTaking people
- Smilow Cancer Hospital Care Center - WaterfordWaterford, United StatesTaking people
- Aspirus Regional Cancer CenterWausau, United StatesTaking people
- Marshfield Clinic-Wausau CenterWausau, United StatesTaking people
- Saint Mary's Oncology/Hematology Associates of West BranchWest Branch, United StatesTaking people
- Mercy Medical Center-West LakesWest Des Moines, United StatesTaking people
- Smilow Cancer Hospital Care Center - WesterlyWesterly, United StatesTaking people
- Marshfield Medical Center - WestonWeston, United StatesTaking people
- Geisinger Wyoming Valley/Henry Cancer CenterWilkes-Barre, United StatesTaking people
- Rice Memorial HospitalWillmar, United StatesTaking people
- Aspirus Cancer Care - Wisconsin RapidsWisconsin Rapids, United StatesTaking people
- Marshfield Clinic - Wisconsin Rapids CenterWisconsin Rapids, United StatesTaking people
- Minnesota Oncology Hematology PA-WoodburyWoodbury, United StatesTaking people
- Woodland Memorial HospitalWoodland, United StatesTaking people
- Sanford Cancer Center WorthingtonWorthington, United StatesTaking people
- Fairview Lakes Medical CenterWyoming, United StatesTaking people
- University of Michigan Health - WestWyoming, United StatesTaking people
- Avera Cancer Institute at YanktonYankton, United StatesTaking people
- Providence Regional Cancer System-YelmYelm, United StatesTaking people
- Rush-Copley Healthcare CenterYorkville, United StatesTaking people
- Saint Elizabeth Youngstown HospitalYoungstown, United StatesTaking people
- Huron Gastroenterology PCYpsilanti, United StatesTaking people
- Trinity Health IHA Medical Group Hematology Oncology Ann Arbor CampusYpsilanti, United StatesTaking people
Questions to ask the study team
- How often do I need to come in, and for how long each time?
- Are travel costs paid?
- Can I keep my own doctor?
- What happens if I want to stop?
Trial details
- Who runs it
- SWOG Cancer Research Network
- Trial code
- NCT05561387
- Record updated
- 10 June 2026
- Original description
This phase III trial compares three-drug induction regimens followed by double-or single-drug maintenance therapy for the treatment of newly diagnosed multiple myeloma in patients who are not receiving a stem cell transplant and are considered frail or intermediate-fit based on age, comorbidities, and functional status. Treatment for multiple myeloma includes initial treatment (induction) which is the first treatment a patient receives for cancer followed by ongoing treatment (maintenance) which is given after initial treatment to help keep the cancer from coming back. There are three combinations of four different drugs being studied. Bortezomib is one of the drugs that may stop the growth of cancer cells by blocking some of the enzymes needed for cell growth. Lenalidomide works by helping bone marrow to produce normal blood cells and killing cancer cells. Anti-inflammatory drugs, such as dexamethasone, lower the body's immune response and are used with other drugs in the treatment of some types of cancer. Daratumumab and hyaluronidase-fihj is a monoclonal antibody that may interfere with the ability of cancer cells to grow and spread. Patients receive 1 of 3 combinations of these drugs for treatment to determine which combination of study drugs works better to shrink and control multiple myeloma.Read full original descriptionShow less
A Phase III Randomized Trial for Newly Diagnosed Multiple Myeloma (NDMM) Patients Considered Frail or in a Subset of "Intermediate Fit" Comparing Upfront Three-Drug Induction Regimens Followed by Double or Single-Agent Maintenance
This phase III trial compares three-drug induction regimens followed by double-or single-drug maintenance therapy for the treatment of newly diagnosed multiple myeloma in patients who are not receiving a stem cell transplant and are considered frail or intermediate-fit based on age, comorbidities, and functional status. Treatment for multiple myeloma includes initial treatment (induction) which is the first treatment a patient receives for cancer followed by ongoing treatment (maintenance) which is given after initial treatment to help keep the cancer from coming back. There are three combinations of four different drugs being studied. Bortezomib is one of the drugs that may stop the growth of cancer cells by blocking some of the enzymes needed for cell growth. Lenalidomide works by helping bone marrow to produce normal blood cells and killing cancer cells. Anti-inflammatory drugs, such as dexamethasone, lower the body's immune response and are used with other drugs in the treatment of some types of cancer. Daratumumab and hyaluronidase-fihj is a monoclonal antibody that may interfere with the ability of cancer cells to grow and spread. Patients receive 1 of 3 combinations of these drugs for treatment to determine which combination of study drugs works better to shrink and control multiple myeloma.
Inclusion: Participants must have documented multiple myeloma satisfying standard International Myeloma Working Group (IMWG) diagnostic criteria within 28 days prior to registration; Participants must have measurable disease within 28 days prior to registration as defined by any of the following:; Immunoglobulin (Ig) G myeloma (serum monoclonal paraprotein [M-protein] level >= 0.5 gram/deciliter [g/dL] or urine M-protein level >= 200 milligram[mg]/24 hours[hrs]); OR; IgA, IgM, IgD, or IgE multiple myeloma (serum M-protein level >= 0.2 g/dL or urine M-protein level >= 200 mg/24 hrs); OR; Light chain multiple myeloma (serum immunoglobulin free light chain >= 10 mg/dL and abnormal serum immunoglobulin kappa lambda free light chain ratio); All disease must be assessed and documented on the baseline/pre-registration tumor assessment form; Participants must have a calculated myeloma frailty index (Myeloma Frailty Score Calculator; http://www.myelomafrailtyscorecalculator.net/) categorized as frail or intermediate fit (regardless of age) within 28 days prior to registration; For Participants Meeting "Frail" Status:; Participants with any degree of kidney dysfunction are allowed; however, participants on dialysis are not eligible; For Participants Meeting "Frail" Status:; Hemoglobin >= 7 g/dL (must be performed within 28 days prior to registration); Note: growth factor and transfusion utilization are allowed if cytopenias are considered secondary to bone marrow involvement from MM); For Participants Meeting "Frail" Status:; Platelets >= 50 x 10\^9/L (must be performed within 28 days prior to registration); Note: growth factor and transfusion utilization are allowed if cytopenias are considered secondary to bone marrow involvement from MM); For Participants Meeting "Frail" Status:; Absolute neutrophil count (ANC) >= 0.75 x10\^9/L (must be performed within 28 days prior to registration); Note: growth factor and transfusion utilization are allowed if cytopenias are considered secondary to bone marrow involvement from MM); For Participants Meeting "Intermediate Fit" Status, one or more of the following criteria must be present:; Kidney dysfunction showing calculated creatinine clearance (CrCl) <30 ml/min; Actual lab serum creatinine value with a minimum of 0.7 mg/dL; Participants must have bone marrow function assessed and meet the below criteria ranges:; Hemoglobin between 7-8 g/dL, OR; Platelets between 50-75 x10\^9/L, OR; ANC between 0.75-1 x10\^9/L; Note: growth factor and transfusion utilization are allowed as long as cytopenias are considered secondary to bone marrow involvement from MM); Revised International Staging System (R-ISS) stage III disease; Note: All labs must be performed within 28 days prior to registration; Participants must have a complete medical history and physical exam within 28 days prior to registration; Participants must have whole body imaging within 60 days prior to registration. The recommended method of imaging is a positron emission tomography/computed tomography (PET/CT); a low-dose whole body CT scan or whole-body magnetic resonance imaging (MRI) or skeletal survey should be done only if a PET/CT scan cannot be done or is non-feasible. This must be documented in the comments section of the Onstudy form; Total bilirubin =< 2 times institutional upper limit of normal (ULN) unless history of Gilbert's disease. Participants with history of Gilbert's disease must have total bilirubin =< 5 x institutional ULN (within 28 days prior to registration); Aspartate aminotransferase (AST)/alanine aminotransferase (ALT) =< 3 × institutional ULN (within 28 days prior to registration); Participants must have adequate cardiac function, as assessed by the treating physician within 14 days prior to registration. Participants with known history or current symptoms of cardiac disease, or history of treatment with cardiotoxic agents, must have a clinical risk assessment of cardiac function using the New York Heart Association Functional Classification and must not be assessed as class 3 or 4; Participants with known diabetes must show evidence of controlled disease within 14 days prior to registration. Uncontrolled diabetes is defined as: A glycosylated hemoglobin (Hg)A1C > 7; Participants with known human immunodeficiency virus (HIV)-infection must be receiving anti-retroviral therapy and have an undetectable viral load test on the most recent test result obtained, within 6 months prior to registration; All participants with evidence of chronic hepatitis B virus (HBV) infection must have undetectable HBV viral load on suppressive therapy within 28 days prior to registration; Participants with a history of hepatitis C virus (HCV) infection must have been treated and cured. For participants with HCV infection who are currently on treatment, participant must have an undetectable HCV viral load within 28 days prior to registration; Participants must have an Eastern Cooperative Oncology Group (ECOG)/Zubrod performance status score of 0-2 (Note: Participants with ECOG/Zubrod performance score [PS] 3, especially where the deterioration of PS is considered secondary to the MM diagnosis, will be allowed); Participants must be offered the opportunity to participate in specimen banking. With participant consent, specimens must be collected and submitted via the Southwest Oncology Group (SWOG) specimen tracking system; Participants who are able to complete the patient-reported outcomes measures in English or Spanish must agree to participate in the PRO portion of the study; Participants must be informed of the investigational nature of this study and must sign and give informed consent in accordance with institutional and federal guidelines. For participants with impaired decision-making capabilities, legally authorized representatives may sign and give informed consent on behalf of study participants in accordance with applicable federal, local, and Central Institutional Review Board (CIRB) regulations.
Exclusion: Participants must not have received any prior systemic therapy for multiple myeloma with the exception of any one or more of the following:; An emergency use of a short course of corticosteroids (equivalent of dexamethasone 160 mg) any time before registration, or; Up to one complete cycle of a non-daratumumab and hyaluronidase-fihj containing anti-myeloma regimen (1 cycle = 21 or 28 days depending on the regimen being used), or; Localized palliative radiation therapy for multiple myeloma, as long as the radiation therapy is completed at least 3 days prior to starting the systemic treatment as per the study protocol; Participants must not have evidence of grade 4 peripheral neuropathy prior to study registration; Participants must not have uncontrolled blood pressure within 14 days prior to registration. Uncontrolled blood pressure: systolic blood pressure (SBP) > 140 mmHg or diastolic blood pressure (DBP) > 90 mmHg. Participants are permitted to be receiving multiple anti-hypertensive medications (unless otherwise indicated in the study). All blood pressure measurements within the 14 days prior to registration must be SBP =< 140 and DBP =< 90. A participant with a single blood pressure elevation who upon rechecking has a normal blood pressure will remain eligible at the discretion of the registering investigator; Participants must not have a prior or concurrent malignancy whose natural history or treatment (in the opinion of the treating physician) has the potential to interfere with the safety or efficacy assessment of the investigational regimen; Participants must not be pregnant or nursing. Individuals who are of reproductive potential must have agreed to use an effective contraceptive method with details provided as a part of the consent process. A person who has had menses at any time in the preceding 24 consecutive months or who has semen likely to contain sperm is considered to be of "reproductive potential." In addition to routine contraceptive methods, "effective contraception" also includes refraining from sexual activity that might result in pregnancy and surgery intended to prevent pregnancy (or with a side-effect of pregnancy prevention) including hysterectomy, bilateral oophorectomy, bilateral tubal ligation/occlusion, and vasectomy with testing showing no sperm in the semen.