Long-term follow-up of a procedure that closes the left atrial appendage in atrial fibrillation
Studies long-term results of closing the heart's left atrial appendage in adults with atrial fibrillation.
Key facts
- Who runs it
- Assistance Publique - Hôpitaux de Paris
- Where
- Créteil, FranceSee the site
- Trial code
- Registry title
- Left Atrial Appendage Closure Registry of Henri Mondor Hospital
- Status
- Recruiting
- People taking part
- 250 people, planned
- Started
- 24 Sept 2022
- Planned end
- 14 Sept 2026
- Type of study
- Observational
- Treatments tested
- SA brief descriptive name used to refer to the intervention(s) studied
- Record updated
- 15 January 2026
Who can take part
AI summary
From the trial's eligibility criteria. Machine-read from the registry text on this page, so it can be wrong. The registry text below and the trial team decide who can take part.
The trial is looking for adults who have been advised to have a device placed to close the left atrial appendage, a small pouch in the heart, to lower stroke risk in atrial fibrillation.
- Age
- 18 years or older
- Sex
- All sexes can join.
- Disease stage
- Any patient for whom doctors have decided on a device to close the left atrial appendage, whatever the reason and whether or not the procedure worked.
Main reasons for not taking part
- Patient refuses to take part
- Minor patient
- Patient not covered by the French social security system
The registry criteria, word for word
Show all 4 criteriaShow less
Who can take part
- Any patient for whom an indication has been made for implantation of a device for the closure of the left atrial appendage without restriction of indication and regardless of the outcome of the procedure (implantation success or not)
Who cannot take part
- Refusal of the patient to participate in this study
- Minor patient
- Patient not affiliated to the French social security system
Where in France
- Assistance Publique - Hopitaux de Paris - CHU Henri MondorCréteil, FranceContact: Emmanuel Teiger, MD, PhDTaking people
About the trial
What the trial wants to find out
Intro: Patients with atrial fibrillation are at significant risk of thrombus formation in the left atrial appendage, which can lead to strokes or systemic embolisms. This risk justifies first-line prescribing of long-term oral anticoagulant therapy in these patients. Percutaneous left atrial appendage closure, is an interventional cardiology technique for patients at high risk of stroke related to atrial fibrillation in whom long term anticoagulation therapy cannot be conducted. This procedure involves implantation of an occlusion device into the left atrial appendage to close it and prevent migration of thrombotic material that could otherwise cause distant embolism. Closure of the left atrial appendage avoids long-term prescription of anticoagulants while protecting patients against the risk of systemic embolism and stroke.
Read full original descriptionShow less
Hypothesis/Objective: the main objective of this study is to assess the long term efficacy of left atrial closure, 5 years after the procedure Method: 150 patients will be included prospectively. We will also include restropectively100 other patients, previously treated by left atrial appendage closure at Henri Mondor hospital. Demographic, clinical, echocardiographic, and computed tomography data will be obtained by physical examination or medical records.
Conclusion: this study will allow to assess the long term efficacy of left atrial closure in atrial fibrillation patients.
Treatments tested
- SA brief descriptive name used to refer to the intervention(s) studied
Questions to ask the study team
- How often do I need to come in, and for how long each time?
- Are travel costs paid?
- Can I keep my own doctor?
- What happens if I want to stop?
Contact the study team: see the registry record → Contacts and Locations
Print a page for my doctorData and sources
- Registry record
- Listed on ClinicalTrials.gov.
- Official title
- Left Atrial Appendage Closure Registry of Henri Mondor Hospital
- Plain-language title
- Long-term follow-up of a procedure that closes the left atrial appendage in atrial fibrillationGenerated from the registry record. The registry title is the official one.
- AI summary
- From the trial's eligibility criteria. Read by machine on 12 November 2026.
- Record updated
- 15 January 2026