Building a lung cancer risk model for people who have never smoked
Checks a risk prediction model for lung cancer in never-smoking people.
Key facts
- Who runs it
- Chung Shan Medical University
- Where
- Hsinchu, Hualien City, Kaohsiung City, New Taipei City, Taichung, and Taipei, TaiwanSee the 7 sites
- Trial code
- Registry title
- Formatting the Risk Prediction Models for Never-Smoking Lung Cancer
- Status
- Recruiting
- People taking part
- 10,000 people, planned
- Started
- 15 Dec 2022
- Expected to end
- 31 Dec 2029
- Type of study
- Observational, 2 groups
- Treatments tested
- LDCT lung cancer screen, immediately
- LDCT lung cancer screen, later
- Record updated
- 17 February 2026
Who can take part
AI summary
From the trial's eligibility criteria. Machine-read from the registry text on this page, so it can be wrong. The registry text below and the trial team decide who can take part.
The trial is looking for people aged 50 to 80 who are first-degree relatives of lung cancer patients. It tests a lung cancer risk model for never-smokers.
- Age
- 50 to 80 years. If the relative with lung cancer was diagnosed under age 50, people older than that diagnosis age can also join.
- Sex
- All sexes can join.
Main reasons for not taking part
- Previous lung cancer
- Another cancer within 5 years (except cervical carcinoma in situ or non-melanomatous skin cancer)
- Cannot tolerate transthoracic procedures or thoracotomy
- Chest CT within the last 18 months
- Known pregnancy
The registry criteria, word for word
Show all 9 criteriaShow less
Who can take part
- Age 50-80 years old
- First-degree relatives of lung cancer patients; aged more than 50 - 80 years old; or older than the age at diagnosis of the youngest lung cancer the proband in the family if they are less than 50 years old
Who cannot take part
- Previous history of lung cancer
- Another malignancy except for cervical carcinoma in situ or non-melanomatous carcinoma of the skin within 5 years
- An inability to tolerate transthoracic procedures or thoracotomy
- Chest CT examination was performed within 18 months
- Hemoptysis of unknown etiology within one month
- Body weight loss of more than 6 kg within one year without an evident cause
- A known pregnancy
Check if you might fit
Answer for yourself. This is not a decision: only the study team can say whether you can take part.
- Are you between 20 and 80 years old?
Where in Taiwan
- National Taiwan University Hospital Hsin Chu BranchHsinchu, TaiwanContact: Chong-Jen Yu, MD PhDTaking people
- Hualien Tzu Chi HospitalHualien City, TaiwanContact: Chung-Ping Hsu, MD PhDTaking people
- E-DA HospitalKaohsiung City, TaiwanContact: Yu-Feng Wei, MD PhDNot yet recruiting
- Kaohsiung Medical University Chung-Ho Memorial HospitalKaohsiung City, TaiwanContact: Inn-Wen Chong, MD PhDTaking people
- Ministry of Health and Welfare Shuang-Ho HospitalNew Taipei City, TaiwanContact: Po-Hao Feng, MD PhDNot yet recruiting
- Chung Shan Medical University HospitalTaichung, TaiwanContact: GEECHEN CHANG, MD, PhDTaking people
- National Taiwan University HospitalTaipei, TaiwanContact: Chao-Chi Ho, MD PhDTaking people
About the trial
What the trial wants to find out
Lung Cancer is the leading cause of cancer-related deaths in Taiwan and worldwide and the incidence is also increasing. The payment for lung cancer which occupies the largest part of National Health Insurance expense is over 15 billion in 2018. Because about 80% lung cancer patients are smokers in western countries the low-dose computed tomography screening focuses on the smoking population It is quite different in South-East Asia particularly in Taiwan that 53% of Taiwan lung cancer are never-smokers and the etiology and the underlying mechanisms are still unknown. The preliminary results of prospective TALENT study indicated that family history plays a key role in tumorigenesis of Taiwan lung cancers but several important variables such as air pollution, biomarkers, radiomics analysis are not available limits the accuracy of lung cancer identification. Hence, it is critical to integrate most of factors involved in lung cancer formation into a multidimensional lung cancer prediction model which could benefit never-smoker lung cancers in Taiwan and East Asia even in the western countries. The investigators initiate a clinical study to validate the multidimensional lung cancer prediction model for never-smoking population by multicenter prospective study.
The 2 groups in the trial
- Never smoker with lung cancer high risk assessment
High risk: above the median of the initial risk model from retrospective study
Treatment: LDCT lung cancer screen, immediately
- Never smoker with lung cancer low risk assessment
Low risk: below the median of the initial risk model from retrospective study
Treatment: LDCT lung cancer screen, later
Questions to ask the study team
- How often do I need to come in, and for how long each time?
- Are travel costs paid?
- Can I keep my own doctor?
- What happens if I want to stop?
Contact the study team: see the registry record → Contacts and Locations
Print a page for my doctorData and sources
- Registry record
- Listed on ClinicalTrials.gov.
- Official title
- Validation and Optimization of Multidimensional Modelling for Never Smoking Lung Cancer Risk Prediction by Multicenter Prospective Study
- Plain-language title
- Building a lung cancer risk model for people who have never smokedGenerated from the registry record. The registry title is the official one.
- AI summary
- From the trial's eligibility criteria. Read by machine on 12 November 2026.
- Fit questions
- Built from NCT05572944, who can take part
- Record updated
- 17 February 2026