Central Sensitization in Total Knee Arthroplasty Patients with Persistent Pain
Key facts
- Who runs it
- University of Barcelona
- Where
- Spain1 site in 1 countryChoose a country to see its sites
- Trial code
- Status
- Completed
- People taking part
- 117 people enrolled
- Started
- 1 Jan 2023
- Ended
- 22 Oct 2024
- Type of study
- Observational, 2 groups
- Treatments tested
- Total Knee Arthroplasty
- Record updated
- 24 October 2024
Who can take part
- Age
- 18 years and older
- Sex
- Women and men
- Healthy volunteers
- Cannot take part
The registry criteria, word for word
Show all 7 criteriaShow less
Who can take part
- Patients who underwent total knee arthroplasty due to painful primary osteoarthritis
Who cannot take part
- Patients operated due to a revision surgery
- Patients with inflammatory or rheumatic diseases such as: rheumatoid arthritis, psoriatic arthritis, systemic lupus erythematosus or ankylosing spondylitis
- Patients with mental health conditions and/or major depression
- Patients with a unicompartmental knee arthroplasty
- Pateints operated due to a fracture
- Patients planning to undergo another lower extremity operation during the following 12 months
This trial has no sites in United States.
It has sites in one country. Choose a country to see its sites.
About the trial
What the trial wants to find out
Persistent post-surgical pain is a significant adverse effect after total knee arthroplasty, present in around 20% of the patients. Central sensitization may contribute to developing and maintaining pain. Therefore studies should investigate if pain processing altered mechanisms are present in this population.
The 2 groups in the trial
- No Persistent Post Surgical Pain
The grouping variable will be the presence or not of persistent post-surgical pain. This will be a dichotomous variable obtained from the evaluation of pain intensity at 3 months after surgery. The tool used will be a 100mm Visual Analog Scale (VAS) (0 = no pain, 100 = worst pain imaginable) (25). Those with a VAS \< 30 will be considered as patients with no persistent pain, while those with a VAS ≥ 30 will be considered as patients with persistent pain. This cut-off point has been determined by numerous authors in previous studies.
Treatment: Total Knee Arthroplasty
- Persistent Post Surgical Pain
While those with a VAS ≥ 30 will be considered as patients with persistent pain. This cut-off point has been determined by numerous authors in previous studies
Treatment: Total Knee Arthroplasty
Data and sources
- Registry record
- Listed on ClinicalTrials.gov.
- Official title
- Central Sesitization in Patients with Persistent Postsurgical Pain After a Knee Arthroplasty: a Prospective, Case Control, Observational Study
- Publications
- Impaired Conditioned Pain Modulation and Peripheral Sensitization in Chronic Postsurgical Pain After Total Knee Arthroplasty.The Clinical journal of pain, 2026
- Record updated
- 24 October 2024