Thyroid Function and Structure in Klinefelter Syndrome
Key facts
- Who runs it
- University of Roma La Sapienza
- Where
- Roma, ItalySee the site
- Trial code
- Status
- Recruiting
- People taking part
- 600 people, planned
- Started
- 11 May 2007
- Expected to end
- 1 Dec 2026
- Type of study
- Observational, 3 groups
- Record updated
- 30 March 2025
Who can take part
- Age
- 1 year to 80 years
- Sex
- Men only
- Healthy volunteers
- Cannot take part
The registry criteria, word for word
Show all 7 criteriaShow less
Who can take part
- Patients with a confirmed diagnosis of classic, non-mosaic 47,XXY Klinefelter syndrome based on a peripheral blood 97 karyotype analysis
- Availability of thyroid function test results (TSH, fT3, and fT4) and/or thyroid US imaging
- Availability of concurrent clinical data
Who cannot take part
- Use of levothyroxine or other drugs that are either active on the hypothalamic-pituitary-thyroid (HPT) axis or that may interfere with thyroid function tests
- History of previous surgery or radiotherapy on the thyroid or pituitary glands
- Current or previous T therapy (for the pre-pubertal and pubertal groups)
- Presence of other known genetic conditions or chromosomal abnormalities
Check if you might fit
Answer for yourself. This is not a decision: only the study team can say whether you can take part.
- Are you between 1 and 80 years old?
Where in Italy
- Sapienza University of RomeRoma, ItalyContact: Andrea Isidori, MD, Ph.D.Taking people
About the trial
What the trial wants to find out
This is a longitudinal retrospective study for the evaluation of thyroid function and structure in patients with Klinefelter syndrome compared to healthy controls and patients affected by chronic lymphocytic thyroiditis.
The 3 groups in the trial
- Klinefelter syndrome
Males affected by 47,XXY non-mosaic Klinefelter syndrome. Subgroups according to pubertal stage: pre-pubertal, pubertal and adults. Subgroups according to gonadal status: eugonadal, hypogonadal and receiving testosterone replacement therapy (TRT).
- Healthy controls
Euthyroid, age- and pubertal stage-matched males Subgroups according to pubertal stage: pre-pubertal, pubertal and adults.
- Chronic lymphocytic thyroiditis
Adult males affected by chronic lymphocytic thyroiditis
Questions to ask the study team
- How often do I need to come in, and for how long each time?
- Are travel costs paid?
- Can I keep my own doctor?
- What happens if I want to stop?
Contact the study team: see the registry record → Contacts and Locations
Print a page for my doctorData and sources
- Registry record
- Listed on ClinicalTrials.gov.
- Official title
- Thyroid Function and Structure in Klinefelter Syndrome (THINKS)
- Fit questions
- Built from NCT05581147, who can take part
- Record updated
- 30 March 2025