Tests magnetic brain stimulation for fatigue after stroke
Tests magnetic brain stimulation against a sham treatment in people with post-stroke fatigue.
Plain-language title generated from the registry record
Registry title: Repetitive Transcranial Magnetic Stimulation, a Form of Non-invasive Brain Stimulation, as a Possible Treatment for Post-stroke Fatigue
Key facts
- Where
- Charleston and Decatur, United StatesSee the 2 sites
- Phase
- Phase 2
Could this be for you?
Answer for yourself. This is not a decision: only the study team can say whether you can take part.
- Are you between 34 and 80 years old?
Source: NCT05584124, who can take part
Where in United States
- Ralph H. Johnson VA Medical CenterCharleston, United StatesNot yet recruiting
- Atlanta VA Medical and Rehab Center, Decatur, GADecatur, United StatesTaking people
Questions to ask the study team
- How often do I need to come in, and for how long each time?
- Are travel costs paid?
- Can I keep my own doctor?
- What happens if I want to stop?
Trial details
- Who runs it
- VA Office of Research and Development
- Trial code
- NCT05584124
- Record updated
- 14 September 2026
- Original description
This experimental trial is investigating the use of magnetic stimulation of the brain as a possible treatment for post-stroke fatigue in people who have had a stroke more than six months prior to enrolling. Fatigue is a common condition after a stroke and can negatively impact an individual's ability to perform desired social and physical activities. Magnetic stimulation of the brain has been shown to improve signs and symptoms of related psychological (e.g., depression) conditions. Participants in this trial will receive a type of magnetic stimulation called repetitive transcranial magnetic stimulation, or rTMS. The investigators will measure feelings of fatigue and other clinical characteristics related to mood and cognition before and after participants receive rTMS.Read full original descriptionShow less
Neuromodulation for Rehabilitation of Post-Stroke Fatigue: An rTMS Pilot Study
This experimental trial is investigating the use of magnetic stimulation of the brain as a possible treatment for post-stroke fatigue in people who have had a stroke more than six months prior to enrolling. Fatigue is a common condition after a stroke and can negatively impact an individual's ability to perform desired social and physical activities. Magnetic stimulation of the brain has been shown to improve signs and symptoms of related psychological (e.g., depression) conditions. Participants in this trial will receive a type of magnetic stimulation called repetitive transcranial magnetic stimulation, or rTMS. The investigators will measure feelings of fatigue and other clinical characteristics related to mood and cognition before and after participants receive rTMS.
Inclusion: More than 6 months post-stroke; Clinically present fatigue.
Exclusion: Contraindications to magnetic resonance imaging (MRI)/transcranial magnetic stimulation (TMS)/repetitive transcranial magnetic stimulation (rTMS), e.g., implanted metal within the head, history of seizures; Diagnosed comorbid neurological conditions (e.g. multiple sclerosis, Parkinson's disease, moderate/severe traumatic brain injury (TBI); Severe hypertension (resting systolic blood pressure (SBP) > 200, DBP > 120); Inability to follow simple three-step instructions; Pregnancy; Strokes within stimulation sites; Pregnancy.