Tracks brain blood flow during heart surgery and later brain complications
Observes whether brain blood flow during heart surgery links to delirium or stroke.
Plain-language title generated from the registry record
Registry title: Impact of Personalised Cardiac Anaesthesia and Cerebral Autoregulation on Neurological Outcomes in Patients Undergoing Cardiac Surgery
Key facts
- Where
- Cambridge, United KingdomSee the 2 sites
Where in United Kingdom
- Cambridge University Hospitals and Brain Physics LabCambridge, United KingdomNo longer taking part
- Royal Papworth Hospital, Department of Anaesthesia and Intensive CareCambridge, United KingdomNo longer taking part
Questions to ask the study team
- How often do I need to come in, and for how long each time?
- Are travel costs paid?
- Can I keep my own doctor?
- What happens if I want to stop?
Trial details
- Who runs it
- University Hospital, Basel, Switzerland
- Trial code
- NCT05595954
- Record updated
- 30 June 2026
- Original description
This international, multicentre prospective cohort study will assess whether perioperative duration and magnitude of mean arterial pressure (MAP) outside of an individual's cerebral autoregulation (CA) limits using near-infrared spectroscopy (NIRS) and transcranial Doppler (TCD) are associated with adverse neurological events. It is to investigate whether patients with a higher burden of cerebral haemodynamic insults have an increased incidence or poorer neurological outcomes. Associations between neurologic outcomes, neurobiomarkers and genetic tests will be explored.Read full original descriptionShow less
Impact of Personalised Cardiac Anaesthesia and Cerebral Autoregulation on Neurological Outcomes in Patients Undergoing Cardiac Surgery (PRECISION)
This international, multicentre prospective cohort study will assess whether perioperative duration and magnitude of mean arterial pressure (MAP) outside of an individual's cerebral autoregulation (CA) limits using near-infrared spectroscopy (NIRS) and transcranial Doppler (TCD) are associated with adverse neurological events. It is to investigate whether patients with a higher burden of cerebral haemodynamic insults have an increased incidence or poorer neurological outcomes. Associations between neurologic outcomes, neurobiomarkers and genetic tests will be explored.
Inclusion: Elective primary or reoperative coronary artery bypass graft and/or valvular and/or ascending aorta surgery requiring cardiopulmonary bypass.
Exclusion: Surgery requiring moderate (28-31.9ºC) or deep (<28ºC) hypothermic circulatory arrest; Urgent (within 24 hours) and emergency surgery; Heart and/or lung transplantation; Inability to give consent; Participants who undergo cardiac surgery under minimal extracorporeal circulation will also be excluded; Inability to follow procedures or insufficient knowledge in English, German or French.