Tests menstrual blood to help predict endometriosis in adults
Tests menstrual blood as a screening aid for endometriosis in people with symptoms.
Plain-language title generated from the registry record
Registry title: Research OutSmarts Endometriosis II Study
Key facts
- Where
- Manhasset, United StatesSee the site
Could this be for you?
Answer for yourself. This is not a decision: only the study team can say whether you can take part.
- Are you between 18 and 40 years old?
Source: NCT05601596, who can take part
Where in United States
- Feinstein Institutes/Northwell healthManhasset, United StatesNo longer taking part
Questions to ask the study team
- How often do I need to come in, and for how long each time?
- Are travel costs paid?
- Can I keep my own doctor?
- What happens if I want to stop?
Trial details
- Who runs it
- Northwell Health
- Trial code
- NCT05601596
- Record updated
- 5 June 2026
- Original description
This product will be used as a diagnostic test to screen for the likelihood of endometriosis in menstruating adults with symptoms suggestive of endometriosis. The purpose of the test will be to guide clinical decisions regarding: 1) whether to undergo diagnostic laparoscopy to confirm the presence of endometriosis (currently, the gold standard for diagnosing endometriosis) and/or 2) how to guide the choice of hormonal or other therapies to treat symptoms of endometriosis.Read full original descriptionShow less
ROSE II: Pilot Study to Analyze Menstrual Blood to Predict Endometriosis
This product will be used as a diagnostic test to screen for the likelihood of endometriosis in menstruating adults with symptoms suggestive of endometriosis. The purpose of the test will be to guide clinical decisions regarding: 1) whether to undergo diagnostic laparoscopy to confirm the presence of endometriosis (currently, the gold standard for diagnosing endometriosis) and/or 2) how to guide the choice of hormonal or other therapies to treat symptoms of endometriosis.
Inclusion: For All; 18 to 40 year old menstruating women (continue to get cycles); More than a light menstrual flow (light flow is soaking less than 1 thin pad or light tampon in 4 hours at peak flow); Willingness to provide two menstrual samples across two separate menstrual cycles; Willingness to provide a DNA sample (obtained via menstrual blood or cheek swab); For Controls:; •General Absence of *symptoms suggestive of endometriosis which includes: 1-Chronic pelvic pain 2-Painful menses 3-Pain during intercourse 4-Pain going to the bathroom 5-Abdominal bloating (BUT MUST NOT Include): 6-Report of missed days of work, school, athletic,social and/or other activities due to related pain and discomfort; For Symptomatic:; Consistently Experiencing chronic symptoms of endometriosis*; Without definitive diagnosis (i.e. pathology report following diagnostic surgery); Seeking physician evaluation (considered by physician to be a candidate for laproscopic surgery; Willingness to provide at least one of the menstrual samples PRIOR to planned surgery; Surgical and pathological confirmation of endo (or NOT).
Exclusion: Report of missed days of work, school, athletic, social and/or other activities due to related pain and discomfort; Symptomatic:; Unable to provide a menstrual sample prior to surgery; under age 18 or over 40 years; For All:; Unable/unwilling to provide a menstrual sample; Light menstrual flow (light flow is soaking less than 1 thin pad or light tampon in 4 hours at peak flow); Diagnosed with endometriosis; CONTROL:; More than 1 symptom of endometriosis*.