Tests accelerated magnetic brain stimulation for treatment-resistant depression
Tests fast-schedule magnetic brain stimulation in adults with depression that has not responded to treatment.
Plain-language title generated from the registry record
Registry title: The Mechanisms of Underlying Accelerated Repetitive Transcranial Magnetic Stimulation for Treatment-resistant Depression
Key facts
- Where
- Hangzhou, ChinaSee the site
Could this be for you?
Answer for yourself. This is not a decision: only the study team can say whether you can take part.
- Are you between 18 and 45 years old?
Source: NCT05607654, who can take part
Where in China
- The First Affiliated Hospital of Zhejiang UniversityHangzhou, ChinaTaking people
Questions to ask the study team
- How often do I need to come in, and for how long each time?
- Are travel costs paid?
- Can I keep my own doctor?
- What happens if I want to stop?
Trial details
- Who runs it
- First Affiliated Hospital of Zhejiang University
- Trial code
- NCT05607654
- Record updated
- 13 January 2023
- Original description
In this project, the investigators evaluate an accelerated schedule of repetitive transcranial magnetic stimulation for treatment-resistant depression. The investigators focuse on participants' brain activity and blood markers (Reelin, Apoer2, NMDAR, BDNF, exosomes and so on) to deepen the understanding of the mechanism of accelerated rTMS for treatment-resistant depression.Read full original descriptionShow less
The Mechanisms of Underlying Accelerated Repetitive Transcranial Magnetic Stimulation for Treatment-resistant Depression Via Reelin-Apoer2-NMDAR Pathway- Mediated Synaptic Plasticity
In this project, the investigators evaluate an accelerated schedule of repetitive transcranial magnetic stimulation for treatment-resistant depression. The investigators focuse on participants' brain activity and blood markers (Reelin, Apoer2, NMDAR, BDNF, exosomes and so on) to deepen the understanding of the mechanism of accelerated rTMS for treatment-resistant depression.
Inclusion: The current episode met the DSM-5 diagnostic criteria for major depression in patients with first-episode or relapsed unmedicated depression without psychotic symptoms; 24-item Hamilton Depression Scale (HAMD-24) ≥ 20; Age 18-45 years, regardless of gender; Right-handedness; Han Chinese; Signed a written informed consent, willing to participate in the study and be evaluated.
Exclusion: Co-morbid other mental disorders, including: schizophrenia, mental retardation, substance dependence, etc; Patients with severe or unstable somatic diseases; Other conditions that, in the opinion of the investigator, exist that make participation in this clinical trial inappropriate; Women during pregnancy or lactation, and women of childbearing age with positive urine HCG test results during the screening period; Patients with metal objects in the body or with other contraindications to MRI scanning.