Tests clot removal with or without carotid stenting in acute stroke
Compares clot removal approaches in adults with acute stroke from a blocked carotid artery.
Plain-language title generated from the registry record
Registry title: Proximal Internal Carotid Artery Acute Stroke Secondary to Tandem or Local Occlusion Thrombectomy Trial
Key facts
- Where
- Akron, Albany, Albuquerque, Atlanta, Bay Shore, Boca Raton, Boston, Charleston, Chicago, Cleveland, Columbus, Delray Beach, Edinburg, Edison, Flint, Glendale, Houston, Indianapolis, Irvine, Jacksonville, Kalamazoo, Kansas City, Lansing, Lexington, Louisville, Lubbock, Marietta, Memphis, Miami, Mobile, Morgantown, Mount Clemens, Munster, New Orleans, New York, Oklahoma City, Orlando, Piscataway, Pittsburgh, Pomona, Providence, Renton, Sacramento, Salt Lake City, San Francisco, Sarasota, Seattle, Shreveport, St Louis, Tampa, The Bronx, Toledo, West Palm Beach, Winfield, Winston-Salem, Worcester, and York, United StatesSee the 60 sites
- Phase
- Phase 3
Could this be for you?
Answer for yourself. This is not a decision: only the study team can say whether you can take part.
- Are you between 18 and 79 years old?
Source: NCT05611242, who can take part
Where in United States
- Cleveland Clinic AkronAkron, United StatesTaking people
- Albany Medical CollegeAlbany, United StatesTaking people
- Univerisity of New MexicoAlbuquerque, United StatesTaking people
- Piedmont HealthcareAtlanta, United StatesTaking people
- Northwell Health/South Shore University HospitalBay Shore, United StatesTaking people
- Boca Raton - Baptist HealthBoca Raton, United StatesTaking people
- Boston Medical CenterBoston, United StatesTaking people
- Medical University of South CarolinaCharleston, United StatesTaking people
- Northwestern UniversityChicago, United StatesTaking people
- University of ChicagoChicago, United StatesTaking people
- Ascension/Alexian Brothers Health SystemChicago, United StatesNo longer taking part
- University HospitalsCleveland, United StatesTaking people
- OhioHealth Research InstituteColumbus, United StatesNo longer taking part
- Delray Medical CenterDelray Beach, United StatesTaking people
- DHR Health Institute for Research and DevelopmentEdinburg, United StatesNo longer taking part
- JFK University Medical CenterEdison, United StatesTaking people
- McLaren-FlintFlint, United StatesTaking people
- Adventist healthGlendale, United StatesTaking people
- HCA Houston KingwoodHouston, United StatesTaking people
- Indiana University Health Methodist HospitalIndianapolis, United StatesTaking people
- University of California, IrvineIrvine, United StatesTaking people
- Baptist Health Research InstituteJacksonville, United StatesTaking people
- University of Florida Health JacksonvilleJacksonville, United StatesTaking people
- Bronson Methodist Hospital/Western Michigan University Homer Stryker M.D. School of MedicineKalamazoo, United StatesTaking people
- University of Kansas Medical CenterKansas City, United StatesTaking people
- Michigan State UniversityLansing, United StatesTaking people
- Baptist Healthcare Systems, IncLexington, United StatesTaking people
- University of LouisvilleLouisville, United StatesTaking people
- Covenant Medical CenterLubbock, United StatesTaking people
- WellStar Health System IncMarietta, United StatesTaking people
- Semmes Murphey FoundationMemphis, United StatesTaking people
- University of Miami School of MedicineMiami, United StatesTaking people
- Mobile Infirmary Medical CenterMobile, United StatesTaking people
- West Virginia UniveristyMorgantown, United StatesTaking people
- McLaren-MacombMount Clemens, United StatesTaking people
- Munster Community HospitalMunster, United StatesNo longer taking part
- Ochsner Medical CenterNew Orleans, United StatesTaking people
- Mount Sinai HospitalNew York, United StatesTaking people
- University of Oklahoma Health Sciences CenterOklahoma City, United StatesTaking people
- Orlando Health, Inc.Orlando, United StatesTaking people
- Rutgers, The State UniversityPiscataway, United StatesTaking people
- Allegheny Health Network Research InstitutePittsburgh, United StatesTaking people
- Pomona ValleyPomona, United StatesTaking people
- Brown UniversityProvidence, United StatesTaking people
- Valley Medical CenterRenton, United StatesTaking people
- Sutter Institute for Medical ResearchSacramento, United StatesTaking people
- University of UtahSalt Lake City, United StatesTaking people
- California Pacific Medical Center/Mils Peninsula Medical CenterSan Francisco, United StatesTaking people
- Sarasota Memorial HospitalSarasota, United StatesTaking people
- University of WashingtonSeattle, United StatesNot yet recruiting
- Louisiana State University Health Sciences Center at ShreveportShreveport, United StatesNo longer taking part
- SSM Health DePaul HospitalSt Louis, United StatesTaking people
- University of South FloridaTampa, United StatesTaking people
- Montefiore Medical CenterThe Bronx, United StatesTaking people
- Mercy Health St. Vincent Medical CenterToledo, United StatesTaking people
- St. Mary's Medical CenterWest Palm Beach, United StatesTaking people
- Northwestern Medicine Central DuPage HospitalWinfield, United StatesTaking people
- Wake Forest University Health SciencesWinston-Salem, United StatesTaking people
- University of MassachusettsWorcester, United StatesTaking people
- WellSpan HealthYork, United StatesTaking people
Questions to ask the study team
- How often do I need to come in, and for how long each time?
- Are travel costs paid?
- Can I keep my own doctor?
- What happens if I want to stop?
Trial details
- Who runs it
- Mercy Health Ohio
- Trial code
- NCT05611242
- Record updated
- 2 October 2026
- Original description
The primary objective is to establish the efficacy of intra-arterial (IA) mechanical thrombectomy (MT) with extracranial proximal carotid artery acute stenting versus non-stenting approaches in patients with acute ischemic stroke (AIS) from intracranial vessel occlusion (IVO) in the anterior circulation and have a proximal carotid occlusive disease (occlusion or severe stenosis).Read full original descriptionShow less
Proximal Internal Carotid Artery Acute Stroke Secondary to Tandem or Local Occlusion Thrombectomy Trial
The primary objective is to establish the efficacy of intra-arterial (IA) mechanical thrombectomy (MT) with extracranial proximal carotid artery acute stenting versus non-stenting approaches in patients with acute ischemic stroke (AIS) from intracranial vessel occlusion (IVO) in the anterior circulation and have a proximal carotid occlusive disease (occlusion or severe stenosis).
Inclusion: 18 to 79 years of age (before the 80th birthday); Presenting with symptoms consistent with AIS; Imaging evidence of an anterior circulation occlusion of the Internal Carotid Artery (ICA) terminus and/or Middle Cerebral Artery Main Stem (MCA M1), or proximal M2 segment AND extra-cranial proximal carotid occlusion / severe stenosis related to atherosclerosis requiring treatment on non-invasive imaging ≥70%; NIHSS ≥ 4; Ability to randomize and start endovascular therapy within 16 hours of stroke onset; Pre-stroke mRS score 0-2; Ability to obtain signed informed consent; ASPECTS Score ≥7 via non-contrast CT or MRI (DWI) for subjects ≤6 hours from stroke onset OR ASPECTS Score ≥7 + infarct core volume <50 cc quantified by CTP (rCBF<30%) OR <25 cc quantified by MRI-DWI (AxBxC/2) for subjects with endovascular therapy starting between >6h to 16 hours from stroke onset, given the need for antiplatelet therapy; Acute Neurological Deficit with Imaging evidence of Tandem Lesion:; Extracranial carotid occlusion (70% to 100% Using NACET criteria) With or without intracranial vascular occlusion; Must be ineligible for IV t-PA therapy or have failed IV t-PA therapy.
Exclusion: Contraindication to antiplatelet (Aspirin, Plavix, Ticagrelor, Cangrelor), or thrombolytic therapy, or contrast agents; Intracranial tumors other than small meningioma that does not require surgery for one year post randomization; Life expectancy less than one year prior to stroke onset; Known severe allergy (more than a rash) to contrast media uncontrolled by medications; Refractory hypertension (defined as persistent systolic blood pressure >185 mmHg or diastolic blood pressure >110 mmHg) despite medication; CT evidence of the following conditions:; Midline shift or herniation; Evidence of intracranial hemorrhage; Mass effect with effacement of the ventricles; Any other condition (in the opinion of the site investigator) that precludes an endovascular procedure or poses a significant hazard to the patient if an endovascular procedure was performed; Females who are pregnant, or those of child-bearing potential with positive urine or serum beta Human Chorionic Gonadotropin (HCG) test; Known hemorrhagic diathesis, coagulation factor deficiency, or on anticoagulant therapy with an International Normalized Ratio (INR) of >1.7 or Partial Thromboplastin Time (PTT) > 3 times of normal; Baseline platelet count <100,000 per microliter (μl); Acute bilateral strokes; Participation in another randomized clinical trial that could confound the evaluation of the study outcomes; Proximal carotid stenosis secondary to dissection or vasculitis (.e.g. Takayasu's Arteritis).