Taking people in FranceNo phase

Long-term Ovarian Function in Young Adults Treated for Lymphoma

Follows ovarian function in young adults with follicular lymphoma after chemotherapy.

Key facts

Who runs it: University Hospital, Lille
Where: Lille, FranceSee the site
Trial code: NCT05616325
Registry title: Long-term Ovarian Fertility in Patients Treated for Lymphoma.
Status: Recruiting
People taking part: 270 people, planned
Started: 22 Aug 2023
Expected to end: Mar 2029
Type of study: Observational
Record updated: 22 May 2026

Who can take part

AI summary

From the trial's eligibility criteria. Machine-read from the registry text on this page, so it can be wrong. The registry text below and the trial team decide who can take part.

The trial is looking for women treated with chemotherapy for lymphoma. They are followed in the fertility program at Lille University Hospital, at least 5 years after chemotherapy ended.

Age: 18 to 45 years
Sex: Women only
Disease stage: History of lymphoma treated with chemotherapy
Earlier treatment: Chemotherapy for lymphoma, ended at least 5 years ago

Main reasons for not taking part

Not followed in the fertility observatory
Cannot attend the trial's medical follow-up for geographical, social or psychological reasons
Does not want to take part
Under guardianship or curatorship

The registry criteria, word for word

Show all 8 criteriaShow less

Who can take part

Patients with a history of lymphoma treated with chemotherapy
followed in the fertility observatory of the Jeanne de Flandre Hospital at the University Hospital of Lille (project "she will heal and then want a child"), who are at least at 5 years since the end of chemotherapy
Patients having been informed and having given their written consent to participate in the study
Beneficiary of a social security system

Who cannot take part

Patient not followed in the fertility observatory
Inability of the patient to undergo the medical follow-up of the trial for geographical, social or psychological reasons
Patient opposed to her participation in the study
Patient under guardianship or curatorship

Check if you might fit

Answer for yourself. This is not a decision: only the study team can say whether you can take part.

Are you between 18 and 45 years old?

Where in France

CHU de LilleLille, FranceContact: Christine DECANTERTaking people

About the trial

What the trial wants to find out

This is an observational, single-center, longitudinal cohort study. In order to evaluate the gonadotoxicity of chemotherapy, an AMH monitoring was initiated in 2006 in our fertility observatory in young patients with lymphoma before, during and after chemotherapy. This study is part of the project "She will get better and then want a child" and is supported by the ARS hauts de France (n° DOS/SDES/AR/FIR/2019/282). Our first study published in 2010 shows that AMH decreases sharply during chemotherapy, regardless of the chemotherapy protocol. At the end of chemotherapy, AMH recovery profiles differ according to the protocol received. This follow-up is therefore essential in order to adapt our practices and our preservation strategies, particularly to the type of chemotherapy. Patients are primarily concerned about their chances of subsequent pregnancy, and there is little evidence in the literature about the impact of chemotherapy on ovarian reserve and long-term fertility.

Read full original descriptionShow less

The fisrt objective of our study is to evaluate, at distance from chemotherapy, the evolution of ovarian function in patients treated for lymphoma by evaluating follicular reserve parameters (AMH and antral follicle count) at 5 and 10 years after the end of chemotherapy compared with the initial workup performed before chemotherapy and the workup performed at 12 months after the end of chemotherapy.