Lemborexant vs Clonidine vs Sedatives to Treat Insomnia in Chronic Pain Patients
Key facts
- Where
- Surrey, CanadaSee the site
Could this be for you?
Answer for yourself. This is not a decision: only the study team can say whether you can take part.
- Are you between 20 and 99 years old?
Source: NCT05618002, who can take part
Where in Canada
- Salem Anaesthesia Pain ClinicSurrey, CanadaContact: Olu Bamgbade, MD, CPI, FRCPC, PMP, DBATaking people
Questions to ask the study team
- How often do I need to come in, and for how long each time?
- Are travel costs paid?
- Can I keep my own doctor?
- What happens if I want to stop?
Contact the study team: see the registry record → Contacts and Locations
Print a page for my doctorTrial details
- Who runs it
- Salem Anaesthesia Pain Clinic
- Trial code
- NCT05618002
- Record updated
- 2 November 2026
- Original description
Prospective observational crossover study of 250 adults undergoing chronic pain management. For insomnia treatment, patients alternate their usual prescribed sedative versus Lemborexant or Clonidine; on alternate nights. Patients use a validated smartwatch and a validated sleep diary to collect data including mood score, sleep score, sleep duration, and adverse effects. Patients complete the diary for 20-25 days. Pain and mood are measured using numeric rating scales. Sleep score is measured using the Likert sleep scale. Within-patient differences are analyzed. Any change in pain, mood, or sleep scores by 2-points is considered significant.Read full original descriptionShow less
Lemborexant vs Clonidine vs Zopiclone vs Other Sedatives for Managing Chronic Insomnia in Chronic Pain Patients
Prospective observational crossover study of 250 adults undergoing chronic pain management. For insomnia treatment, patients alternate their usual prescribed sedative versus Lemborexant or Clonidine; on alternate nights. Patients use a validated smartwatch and a validated sleep diary to collect data including mood score, sleep score, sleep duration, and adverse effects. Patients complete the diary for 20-25 days. Pain and mood are measured using numeric rating scales. Sleep score is measured using the Likert sleep scale. Within-patient differences are analyzed. Any change in pain, mood, or sleep scores by 2-points is considered significant.
Inclusion: adult chronic pain patients; good treatment compliance; severe chronic insomnia; failure of non-pharmacologic sleep therapy; regular night sedative therapy for 3 months or more; regular sleep diary; regular pain and mood diary; informed consent for diary review; consent for clinical record quality assurance review.
Exclusion: regular sedative therapy for less than 3 months; previous adverse/allergic reactions to clonidine or zopiclone; organ insufficiency; cognitive disorder; major neuropsychiatric disorder; obstructive sleep apnoea; body mass index (BMI) ≥40; inability to provide consent; unreliable diary; cannabis use; regular alcohol intake; stimulant use; substance abuse; poor treatment compliance; high dose opioid; gabapentinoid use; other sedative use; mild insomina; irregular sedative intake.