Measuring Immune-Suppressing Cells in Blood of People With Cancer
Measures immune-suppressing cells in blood of adults with several cancer types.
Plain-language title generated from the registry record
Registry title: Quantifying Systemic Immunosuppression to Personalize Cancer Therapy
Key facts
- Where
- Milan, ItalySee the site
Could this be for you?
Answer for yourself. This is not a decision: only the study team can say whether you can take part.
- Are you between 18 and 90 years old?
Source: NCT05621837, who can take part
Where in Italy
- Fondazione IRCCS - Istituto Nazionale dei TumoriMilan, ItalyTaking people
Questions to ask the study team
- How often do I need to come in, and for how long each time?
- Are travel costs paid?
- Can I keep my own doctor?
- What happens if I want to stop?
Trial details
- Who runs it
- Fondazione IRCCS Istituto Nazionale dei Tumori, Milano
- Trial code
- NCT05621837
- Record updated
- 2 May 2025
- Original description
The Serpentine (Stratify cancER PatiENTs by ImmuNosupprEssion) project, represents the most consistent effort so far attempted to translate MDSC into clinical practise by producing an off-the-shelf compliant assay for quantifying these cells in peripheral blood.Read full original descriptionShow less
Quantifying Systemic Immunosuppression to Personalize Cancer Therapy
The Serpentine (Stratify cancER PatiENTs by ImmuNosupprEssion) project, represents the most consistent effort so far attempted to translate MDSC into clinical practise by producing an off-the-shelf compliant assay for quantifying these cells in peripheral blood.
Inclusion: Histologically documented diagnosis of metastatic/locally advanced melanoma, hormone-refractory breast cancer, RCC and UC, SCCHN, SCC or NSCLC, stage III resectable NSCLC will also be included; Will and ability to comply with the protocol; Willingness and ability to provide an adequate archival Formalin-Fixed Paraffin-Embedded (FFPE) tumor sample available for exploratory biomarker analysis; Age from 18 to 90 years at the time of recruitment; ECOG Performance Status <= 2; Understanding and signature of the informed consent; Consenting to participate to the socio-economical-psychological survey.
Exclusion: Known history of HIV infection; Serious neurological or psychiatric disorders; Pregnancy or lactation; Inability or unwillingness of participant to give written informed consent; Inability or unwillingness to be regularly followed up at the same center.