Studies where blood clots come from in people with ischaemic stroke
Uses a clot-targeting PET scan to study clots in adults with ischaemic stroke.
Plain-language title generated from the registry record
Registry title: The Origin and Role of Thromboembolism in the Pathogenesis of Ischaemic Stroke
Key facts
- Where
- Edinburgh, United KingdomSee the site
Where in United Kingdom
- Clinical Research FacilityEdinburgh, United KingdomTaking people
Questions to ask the study team
- How often do I need to come in, and for how long each time?
- Are travel costs paid?
- Can I keep my own doctor?
- What happens if I want to stop?
Trial details
- Who runs it
- University of Edinburgh
- Trial code
- NCT05636748
- Record updated
- 11 September 2026
- Original description
Ischaemic stroke is usually due to occlusion of a cerebral artery by thrombus. However, it is often difficult to identify the source of thrombus, or to confirm thrombus as a cause of ischaemic stroke. Moreover, it is debated whether thrombosis plays any role in certain types of stroke such as lacunar stroke. In preliminary studies, the investigators have evaluated a novel clinical grade thrombus-specific radiotracer, 18F-GP1, which has a high specificity for the glycoprotein IIb/IIIa receptor on activated platelets. The investigations have demonstrated that 18F-GP1 is highly sensitive to in vivo thrombus formation and demonstrates avid binding to thrombus associated with myocardial infarction, pulmonary embolism and aortic bioprosthesis. This study will use this imaging approach to define the role and origin of thrombus in patients with ischaemic stroke, cryptogenic stroke and lacunar stroke.The investigators will also assess its added clinical value in assessing patients with ischaemic stroke.Read full original descriptionShow less
The Origin and Role of Thromboembolism in the Pathogenesis of Ischaemic Stroke
Ischaemic stroke is usually due to occlusion of a cerebral artery by thrombus. However, it is often difficult to identify the source of thrombus, or to confirm thrombus as a cause of ischaemic stroke. Moreover, it is debated whether thrombosis plays any role in certain types of stroke such as lacunar stroke. In preliminary studies, the investigators have evaluated a novel clinical grade thrombus-specific radiotracer, 18F-GP1, which has a high specificity for the glycoprotein IIb/IIIa receptor on activated platelets. The investigations have demonstrated that 18F-GP1 is highly sensitive to in vivo thrombus formation and demonstrates avid binding to thrombus associated with myocardial infarction, pulmonary embolism and aortic bioprosthesis. This study will use this imaging approach to define the role and origin of thrombus in patients with ischaemic stroke, cryptogenic stroke and lacunar stroke.The investigators will also assess its added clinical value in assessing patients with ischaemic stroke.
Inclusion: Males and females ≥18 years old; Diagnoses of acute ischaemic stroke (within 21 days of symptom onset) as per American Heart and Stroke Association guidelines.
Exclusion: Participation in the study would result in a delay to carotid endarterectomy surgery; Known allergy to iodinated contrast or radiotracer; Haemorrhagic stroke; Inability or unwillingness to provide informed written consent (ie lack capacity); Inability to undergo the scanning protocol including ability to transfer onto the scanner; Women of child- bearing potential in whom pregnancy cannot be excluded; Contraindication to PET-CT scanning including estimated glomerular filtration rate <30 mL/min/1.73 m2; Severe or significant comorbidity precluding ability to complete study procedures; Contra-indication to Magnetic Resonance imaging for those patients requiring a MRI Head.