Tests pentoxifylline and celecoxib added to phenytoin for epilepsy
Tests two added drugs alongside phenytoin in adults with grand-mal epilepsy.
Key facts
- Who runs it
- Mostafa Bahaa
- Where
- Al Mansurah, EgyptSee the site
- Trial code
- Registry title
- Clinical Study Evaluating Safety of Pentoxifylline and Celecoxib in Patients With Grand-Mal Epilepsy Treated by Phenytoin Monotherapy
- Status
- Recruiting
- Phase
- Phase 2
- People taking part
- 90 people, planned
- Started
- 20 Dec 2022
- Expected to end
- 20 Nov 2027
- Type of study
- Interventional, 3 groupsOne group gets an existing treatment, for comparison.
- Treatments tested
- Phenytoin
- Pentoxifylline 400 MG
- Celecoxib 200mg
- Record updated
- 18 July 2024
Who can take part
AI summary
From the trial's eligibility criteria. Machine-read from the registry text on this page, so it can be wrong. The registry text below and the trial team decide who can take part.
The trial is looking for adults with grand mal epilepsy who take phenytoin as their only epilepsy medicine.
- Age
- 18 to 75 years
- Sex
- All sexes can join.
- Disease stage
- Grand mal epilepsy.
- Earlier treatment
- Must be on phenytoin alone. Cannot be using other epilepsy drugs.
Main reasons for not taking part
- Significant liver or kidney problems
- Alcohol or drug abuse
- Known allergy to the study drugs or to sulfonamides
- Pregnant women or women planning a pregnancy
- Heart disease or past coronary bypass surgery
The registry criteria, word for word
Show all 2 criteriaShow less
Who can take part
- Patients aged ≥ 18 years old. Patients with grand mal epilepsy on phenytoin monotherapy. Women with a negative pregnancy test and women on effective contraception
Who cannot take part
- Patients with significant liver and kidney function abnormalities. Alcohol and/or drug abusers. Patients with known allergies to the study medications Patients with known allergy to sulfonamides (cross hypersensitivity with celecoxib); Pregnant women and women with a planned pregnancy. Subjects on medication are known to have possible positive effects on epilepsy. Patients who are currently using other antiepileptic drugs. Patients with CVD and a history of coronary artery bypass graft (CABG) surgery. Patients on aspirin or fluconazole therapy Patients with a recent retinal or cerebral hemorrhage
Check if you might fit
Answer for yourself. This is not a decision: only the study team can say whether you can take part.
- Are you between 18 and 75 years old?
Where in Egypt
- Mansoura UniversityAl Mansurah, EgyptContact: Maha Younis, PhDTaking people
About the trial
What the trial wants to find out
Epilepsy is a chronic neurological disorder affecting millions of people all over the world. Epileptic seizures are caused by abnormal synchronized electrical neuronal discharges that could be either focal or widespread. Pathogenesis of epilepsy involves multiple processes including genetics, oxidative stress, ion channels, neuroinflammation, and cellular damage through autophagy and apoptosis.
Read full original descriptionShow less
Neuroinflammation is considered one of the most important factors contributing critically to epileptogenesis.
The 3 groups in the trial
- Control GroupTreatment being tested
This group will receive 100 mg of phenytoin 3 times daily for 6 months.
Treatment: Phenytoin
- Pentoxifylline groupExisting treatment, for comparison
This group will receive 100 mg of phenytoin 3 times daily plus pentoxifylline 400 mg two times daily for 6 months
Treatment: Phenytoin and Pentoxifylline 400 MG
- Celecoxib groupExisting treatment, for comparison
This group will receive 100 mg of phenytoin 3 times daily plus celecoxib 200 mg once daily for 6 months
Treatment: Phenytoin and Celecoxib 200mg
Questions to ask the study team
- How often do I need to come in, and for how long each time?
- Are travel costs paid?
- Can I keep my own doctor?
- What happens if I want to stop?
Contact the study team: see the registry record → Contacts and Locations
Print a page for my doctorData and sources
- Registry record
- Listed on ClinicalTrials.gov.
- Official title
- Clinical Study Evaluating and Comparing the Safety and the Possible Efficacy of Pentoxifylline and Celecoxib in Patients With Grand-Mal Epilepsy Treated by Phenytoin Monotherapy
- Plain-language title
- Tests pentoxifylline and celecoxib added to phenytoin for epilepsyGenerated from the registry record. The registry title is the official one.
- AI summary
- From the trial's eligibility criteria. Read by machine on 12 November 2026.
- Fit questions
- Built from NCT05637086, who can take part
- Record updated
- 18 July 2024