Tests brain scan neurofeedback added to usual care for depression
Compares brain scan neurofeedback plus usual care with usual care in adults with depression.
Plain-language title generated from the registry record
Registry title: FMRI-neurofeedback in Depression
Key facts
- Where
- Maastricht, NetherlandsSee the 3 sites
Where in Netherlands
- Maastricht UMCMaastricht, NetherlandsTaking people
- Maastricht UniversityMaastricht, NetherlandsTaking people
- Mondriaan ZorggroepMaastricht, NetherlandsTaking people
Questions to ask the study team
- How often do I need to come in, and for how long each time?
- Are travel costs paid?
- Can I keep my own doctor?
- What happens if I want to stop?
Trial details
- Who runs it
- Maastricht University Medical Center
- Trial code
- NCT05640089
- Record updated
- 13 October 2026
- Original description
Previous studies with fMRI-neurofeedback in depression have demonstrated a good safety profile and considerable symptom reduction. The goal of this clinical trial is to compare fMRI-neurofeedback plus standard care with standard care in patients with depression.Read full original descriptionShow less
A Randomised Controlled Trial of fMRI-neurofeedback in Depression
Previous studies with fMRI-neurofeedback in depression have demonstrated a good safety profile and considerable symptom reduction. The goal of this clinical trial is to compare fMRI-neurofeedback plus standard care with standard care in patients with depression.
Participants will either receive standard care, or standard care plus a fMRI neurofeedback training, consisting of 5 neurofeedback training sessions. Symptom severity will be assessed before, immediately after and 6 months after the intervention.
Inclusion: Diagnosis of a depressive disorder (ICD-10: F32 or F33); Has been on stable antidepressant medication (single or combination treatment) for at least 4 weeks; Current depression (QIDS >= 17); If required to meet recruitment targets the minimum entry score will be reduced QIDS >= 13 (i.e. still corresponding to a moderate level of depression).
Exclusion: Current use of illegal drugs (any in the last four weeks); Exclusion criteria for MRI (e.g. cardiac pacemaker, certain metallic implants); History of psychotic disorder bipolar disorder, or psychotic depression; History of neurological disease that could influence the fMRI signal and/or the anatomical alignment (e.g. territorial stroke, multiple sclerosis, brain tumour); Current excessive alcohol consumption that interferes with daily functioning.