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RESTORES Trial: RESToration Of Rehabilitative Function With Epidural Spinal Stimulation

Key facts

Who runs it
National Neuroscience Institute
Where
Singapore1 site in 1 countryChoose a country to see its sites
Trial code
Status
Recruiting
People taking part
18 people, planned
Started
19 Dec 2022
Expected to end
30 Dec 2031
Type of study
Interventional
Treatments tested
  • RESToration Of Rehabilitative function with Epidural spinal Stimulation
Record updated
26 January 2026

Who can take part

Age
21 years and older
Sex
Women and men
Healthy volunteers
Cannot take part

The registry criteria, word for word

Show all 13 criteriaShow less

Other criteria

  • ⦁ Inclusion Criteria
  • For inclusion in the study, the potential patient has to fulfil all of the following criteria:
  • 21 years old and older
  • Chronic (greater than one year) motor complete (AIS classification A or B) SCI
  • Spinal injury between the levels of Cervical 2 (C2) to Thoracic 12 (T12)
  • Segmental reflexes that remain functional below the level of lesion
  • Able to perform the perioperative rehabilitation program as judged by the research team; Exclusion Criteria; Potential patients will be excluded from the trial if they fulfil any of the following criteria:
  • Significant medical co-morbidities that would significantly increase the risk of the operation
  • Severe dysautonomia with systolic blood pressure fluctuation less than 50 or more than 200mmHg on tilt table testing
  • Painful musculoskeletal dysfunction, contractures, unhealed fractures, pressure sores, severe spasticity, and osteoporosis
  • Significant psychological issues or ongoing drug abuse
  • Pregnancy and lactating patients
  • Progressive spinal cord disease

This trial has no sites in United States.

It has sites in one country. Choose a country to see its sites.

About the trial

What the trial wants to find out

Spinal Cord Injury (SCI), being a devastating diagnosis, has little to no recovery which leads to a long-standing of debilitating impairment for affected patients. The NNI Neurosurgery team, together with our collaborators, are expanding our recruitment from our pilot trial named RESTORES: RESToration of Rehabilitative function with Epidural Spinal Stimulation. This study aims to investigate the feasibility of electrical stimulation via a spinal cord stimulator (SCS), which will be implanted into the study subjects, and advanced robotic neurorehabilitation to aid in improving neurological function in patients diagnosed with chronic SCI. An additional 15 patients on top of the 3 ongoing patients, male and female participants, above the age of 21 who have been diagnosed with the condition for more than a year will be recruited for this study over a 2-year period. Rehab sessions will take place pre and post-surgical implant, assessing subject improvements

The group in the trial

  • Patients with motor complete chronic spinal cord injuryOther group

    Treatment: RESToration Of Rehabilitative function with Epidural spinal Stimulation

Questions to ask the study team

  1. How often do I need to come in, and for how long each time?
  2. Are travel costs paid?
  3. Can I keep my own doctor?
  4. What happens if I want to stop?

Contact the study team: see the registry record → Contacts and Locations

Print a page for my doctor

Data and sources

Registry record
Listed on ClinicalTrials.gov.
Publications
Record updated
26 January 2026