Urine Testing to Screen for Bladder Cancer in High-Risk Patients
Tests regular urine checks every 6 months to find bladder cancer early in high-risk people.
Key facts
- Who runs it
- University of Texas Southwestern Medical Center
- Where
- Dallas, United StatesSee the site
- Trial code
- Registry title
- Bladder Cancer Screening Trial
- Status
- Recruiting
- People taking part
- 1,000 people, planned
- Started
- 5 May 2023
- Expected to end
- Apr 2028
- Type of study
- Interventional, 2 groupsOne group gets no study treatment, for comparison.
- Treatments tested
- Urinalysis
- Record updated
- 1 May 2026
Who can take part
AI summary
From the trial's eligibility criteria. Machine-read from the registry text on this page, so it can be wrong. The registry text below and the trial team decide who can take part.
The trial is looking for people aged 50 or older who are at high risk of bladder cancer. They will give a urine test every 6 months for 2 years.
- Age
- 50 years or older
- Sex
- All sexes can join
Main reasons for not taking part
- Past bladder, kidney or prostate cancer
- Checked for blood in the urine in the last 2 years
- Not giving informed consent
The registry criteria, word for word
Show all 6 criteriaShow less
Who can take part
- Age ≥ 50
- Smoking: ≥15 pack-year smoking history
- Occupation:≥ 15 years of occupational exposures including: textile worker, painter, dry cleaners
Who cannot take part
- Prior history of bladder, kidney, or prostate cancer
- Prior evaluation of micro or gross hematuria within the last 2 years
- Do not provide informed consent
Where in United States
- University of Texas Southwestern Medical CenterDallas, United StatesContact: Sonobia GarrettTaking people
About the trial
What the trial wants to find out
There is currently no accepted screening strategy for patients at high risk of developing bladder cancer. This study will ask patients to complete a urine test every 6 months for 2 years to help assess if routine screening helps finding bladder cancer at an earlier stage.
The 2 groups in the trial
- BCa Early Screening GroupTreatment being tested
All participants undergo Urinalysis testing every 6 months for 2 years. Based on the RBC count, each participant will go through each of the screening procedures : \[cystoscopy + Upper tract imaging\] or \[urine marker cancer testing with Cxbladder triage + Upper tract imaging\] or \[Repeat urinalysis\] Patients with suspicious findings on cystoscopy or imaging will get treatment as per standard of care. Their outcomes will be compared to a historical control (bladder cancer detected by standard of care using SEER registries).
Treatment: Urinalysis
- Historical Control GroupNo study treatment, for comparison
This will include historical control (bladder cancer detected in patients by standard of care) using SEER registries).
Questions to ask the study team
- How often do I need to come in, and for how long each time?
- Are travel costs paid?
- Can I keep my own doctor?
- What happens if I want to stop?
Contact the study team: see the registry record → Contacts and Locations
Print a page for my doctorData and sources
- Registry record
- Listed on ClinicalTrials.gov.
- Official title
- Optimal Screening Strategy for Bladder Cancer in at Risk Patients
- Plain-language title
- Urine Testing to Screen for Bladder Cancer in High-Risk PatientsGenerated from the registry record. The registry title is the official one.
- AI summary
- From the trial's eligibility criteria. Read by machine on 12 November 2026.
- Record updated
- 1 May 2026