HFNO Improves Blood Oxygen Saturation During Asphyxia During Pulmonary Surgery With Double-lumen Endotracheal Intubation
Key facts
- Who runs it
- Shenzhen Second People's Hospital
- Where
- China1 site in 1 countryChoose a country to see its sites
- Trial code
- Status
- Completed
- People taking part
- 112 people enrolled
- Started
- 20 Mar 2023
- Ended
- 31 May 2024
- Type of study
- Interventional, 2 groupsOne group gets no study treatment, for comparison.
- Treatments tested
- HFNO
- Record updated
- 13 November 2026
Who can take part
- Age
- 18 years to 60 years
- Sex
- Women and men
- Healthy volunteers
- Cannot take part
The registry criteria, word for word
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Who can take part
- Age 18-60
- Patients planning to undergo video-assisted thoracoscopic (VATS) lung surgery requiring DLT intubation
- Patients who agreed to participate in this study
Who cannot take part
- Emergency surgery
- Patients at high risk of reflux aspiration, including ileus, full stomach, esophageal reflux disease
- American Society of Anesthesiologists (ASA) classification > IV
- Patients with severe nasal obstruction; expected difficult intubation or difficulty with mask ventilation
- Morbid obesity [Body Mass Index (BMI)>35kg/m2)]
- Airway anatomical abnormalities
- Abnormal coagulation function
- Pregnant or breastfeeding women
This trial has no sites in United States.
It has sites in one country. Choose a country to see its sites.
About the trial
What the trial wants to find out
With the continuous strengthening of the concept of rapid rehabilitation, great progress has been made in minimally invasive thoracic surgery, and thoracoscopic surgery has developed rapidly. Double-lumen endotracheal(DLT) intubation is still the most reliable way of intubation in lung surgery. However, hypoxemia faced during double-lumen intubation still threatens the perioperative safety of thoracic surgery patients. In recent years, high-flow nasal oxygenation (HFNO) has great potential in the field of anesthesia, especially playing a new and important role in the prevention and treatment of short-term hypoxia and life-threatening airway emergencies. However, the use of HFNO in pulmonary surgery patients with poor pulmonary function lacks evidence-based basis, and there are few reliable clinical data.
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This study adopted a prospective, randomized, controlled, single-blind design. A total of 100 patients aged 18-60 years who underwent elective thoracoscopy-assisted pulmonary surgery were included and randomly divided into the experimental group: HFNO was used in the process of double-lumen intubation asphyxia; the control group: according to the traditional intubation process, No oxygen therapy equipment was used during intubation asphyxiation. The lowest blood oxygen saturation during intubation, the incidence of hypoxemia during intubation, perioperative complications, and postoperative hospital stay were compared between the two groups.
This study explores the advantages of HFNO in complex endotracheal intubation, assuming that HFNO can improve the oxygen saturation of double-lumen intubation; optimize the intubation method of DLT, and tap its new potential to prevent and manage emergency airway crisis.
The 2 groups in the trial
- HFNO groupTreatment being tested
Direct guidance and positioning of DLT intubation with FOB visualization, using HFNO during intubation asphyxia.
Treatment: HFNO
- Control groupNo study treatment, for comparison
The DLT cannula was directly guided and positioned under FOB visualization, and no oxygen therapy equipment was used during intubation.
Data and sources
- Registry record
- Listed on ClinicalTrials.gov.
- Official title
- High-flow Nasal Oxygenation Improves Blood Oxygen Saturation During Asphyxia During Pulmonary Surgery With Double-lumen Endotracheal Intubation: a Randomized Controlled Study
- Record updated
- 13 November 2026