Tests ketone esters added to usual care for children with drug-resistant epilepsy
Tests ketone esters added to usual medicine in children with hard-to-control epilepsy.
Plain-language title generated from the registry record
Registry title: Exogenous Ketone Esters for Drug Resistant Epilepsy
Key facts
- Where
- Sohag, EgyptSee the site
- Phase
- Phase 2/3
Could this be for you?
Answer for yourself. This is not a decision: only the study team can say whether you can take part.
- Are you between 1 and 16 years old?
Source: NCT05670847, who can take part
Where in Egypt
- Department of Pediatrics at Sohag University HospitalSohag, EgyptTaking people
Questions to ask the study team
- How often do I need to come in, and for how long each time?
- Are travel costs paid?
- Can I keep my own doctor?
- What happens if I want to stop?
Trial details
- Who runs it
- Sohag University
- Trial code
- NCT05670847
- Record updated
- 27 November 2024
- Original description
This study aims to investigate the efficacy of add-on exogenous ketone esters for treating children with drug-resistant epilepsyRead full original descriptionShow less
Efficacy of Ketone Esters for Children With Drug Resistant Epilepsy
This study aims to investigate the efficacy of add-on exogenous ketone esters for treating children with drug-resistant epilepsy
Inclusion: Drug-resistant epilepsy; Seizure frequency ≥ 7 per week.
Exclusion: Recent propofol therapy; Intake of carbonic-anhydrase inhibitors; Failure to obtain informed consent; Severe disease conditions, including hepatic, renal, respiratory, cardiac, gastrointestinal, endocrinal, and immune systems; GIT disorders, including gastritis/peptic ulcer, diarrhea/constipation, and irritable bowel disease; Chromosomal disorders; Surgically-remediable epilepsy; Allergies or any other contraindication to ketone supplements; Inapplicable recording of seizures; Incompliance to anti-seizure medications and/or irregular follow-up; Ketosis (βHB > 2 mmol/L); Recent intake of exogenous ketones, ketogenic diet, or any dietary restrictions/modifications; Hypo-/hyperglycemia; Metabolic acidosis; Malnutrition/obesity; Limitations to oral feeding (e.g., severe gastroesophageal reflux); Inborn errors of metabolism.