Tests a chemotherapy artery procedure for lung cancer and lung tumors

Trial details

Who runs it

City of Hope Medical Center

Trial code

NCT05672108

Record updated

5 March 2026

Original description

This phase II trial evaluates how well transarterial chemoembolization (TACE) works for treating patients with non-small cell lung cancer or lung metastases. TACE is a minimally invasive procedure that involves injecting chemotherapy directly into an artery that supplies blood to tumors, and then blocking off the blood supply to the tumors. Mitomycin (chemotherapy), Lipiodol (drug carrier), and Embospheres (small plastic beads that block off the artery) are injected into the tumor-feeding artery. This traps the chemotherapy inside the tumor and also cuts off the tumor\'s blood supply. As a result, the tumor is exposed to a high dose of chemotherapy, and is also deprived of nutrients and oxygen. TACE can be effective at controlling or stopping the growth of lung tumors.Read full original descriptionShow less

Phase II Trial of Lung Chemoemobolization

This phase II trial evaluates how well transarterial chemoembolization (TACE) works for treating patients with non-small cell lung cancer or lung metastases. TACE is a minimally invasive procedure that involves injecting chemotherapy directly into an artery that supplies blood to tumors, and then blocking off the blood supply to the tumors. Mitomycin (chemotherapy), Lipiodol (drug carrier), and Embospheres (small plastic beads that block off the artery) are injected into the tumor-feeding artery. This traps the chemotherapy inside the tumor and also cuts off the tumor\'s blood supply. As a result, the tumor is exposed to a high dose of chemotherapy, and is also deprived of nutrients and oxygen. TACE can be effective at controlling or stopping the growth of lung tumors.

Inclusion: Lung cancer or lung metastases, with lung, endobronchial, pleural, or mediastinal tumors that are progressing on systemic therapy (or the patient cannot tolerate systemic therapy), and that are not amenable to resection, thermal ablation, or ablative radiation therapy; Lung-dominant disease (majority of active tumor volume is in the chest); At least 18 years old.

Exclusion: Planned radioactive iodine imaging or therapy (contraindication to lipiodol); Allergy to iodinated contrast that cannot be treated with steroid / diphenhydramine premedication; Any condition that, in the opinion of the investigator, would interfere with evaluation of the investigational product, or that would affect subject safety; No measurable treatable disease, per Response Evaluation Criteria in Solid Tumors (RECIST) version 1.1 (for example, unable to measure tumor size on CT, or lung nodules are all \< 1 cm); Pulmonary hypertension (diagnosed or suspected on echocardiography, CT, magnetic resonance imaging [MRI], or direct pressure measurement); Active lung infection (pneumonia, empyema, or lung abscess requiring therapy within 1 month); Symptomatic heart failure (American College of Cardiology [ACC]/American Heart Association [AHA] stage C or D); Hyperthyroidism or history of hyperthyroidism, including subclinical hyperthyroidism (contraindication to lipiodol); Allergy to lipiodol or mitomycin; Renal failure (estimated glomerular filtration rate [eGFR] \< 30 mL/min/1.73 m\^2); Platelets \< 50,000 (after transfusion, if needed); International normalized ratio (INR) \> 2 (after transfusion, if needed); Hemoglobin \< 7 (after transfusion, if needed); Eastern Cooperative Oncology Group (ECOG) performance status \> 2; Oxygen saturation \< 92% on room air; Forced expiratory volume in 1 second (FEV1) \< 60%; Life expectancy \< 6 months; Recent pulmonary embolism (within 3 months); Pulmonary arteriovenous malformation; Left bundle branch block (contraindication to pulmonary angiography); Pregnancy or intent to become pregnant; Breast feeding; Altered mental status that would interfere with consent or follow-up.

ClinicalTrials.gov NCT05672108