Stool Transplant Study for Children with Ulcerative Colitis
Tests stool microbiota transplants with partial enteral nutrition in children with active ulcerative colitis.
Plain-language title generated from the registry record
Registry title: Fecal Microbiota Transplantation in Pediatric Ulcerative Colitis (UC)
Key facts
- Where
- Wuhan, ChinaSee the site
AI summary: who the study is looking for
From the trial's eligibility criteria. Machine-read from the registry text on this page, so it can be wrong. The registry text below and the trial team decide who can take part.
The trial is looking for children with mild-to-moderate ulcerative colitis. One group is newly diagnosed. The other group did not improve with usual treatment.
- Age
- Older than 2 years and younger than 16 years
- Sex
- All sexes
- Disease stage
- Mild-to-moderate ulcerative colitis (PUCAI of >10 and ≤64). Either newly diagnosed, or not helped by usual treatment (hormone, immunosuppressant, biologics).
- Earlier treatment
- Newly diagnosed group: must not have had corticosteroids, methotrexate, thiopurines or anti-TNF agents as first treatment. Refractory group: usual treatment must have failed.
Main reasons for not taking part
- Genetic diseases
- Treated with partial enteral nutrition (PEN) (80%) for less than 8 weeks
- Known contraindication to all FMT infusion methods
- Not willing to give consent or assent
- Not agreeing to regular colonoscopy
Read by machine on 9 November 2026.
Could this be for you?
Answer for yourself. This is not a decision: only the study team can say whether you can take part.
- Are you between 2 and 16 years old?
Source: NCT05679622, who can take part
Where in China
- Tongji HospitalWuhan, ChinaTaking people
Questions to ask the study team
- How often do I need to come in, and for how long each time?
- Are travel costs paid?
- Can I keep my own doctor?
- What happens if I want to stop?
Contact the study team: see the registry record → Contacts and Locations
Print a page for my doctorTrial details
- Who runs it
- Biao Zou
- Trial code
- NCT05679622
- Record updated
- 10 July 2026
- Original description
This study included two topics: one was to test the efficacy and safety of fecal microbiota transplants plus partial enteral nutrition (PEN) in refractory pediatric UC where conventional therapy has failed, and the other was to explore the efficacy and safety of FMT plus PEN as first-line therapy for pediatric active UCRead full original descriptionShow less
Repeated and Multiple Fecal Microbiota Transplantations in Active Pediatric Ulcerative Colitis (UC)
This study included two topics: one was to test the efficacy and safety of fecal microbiota transplants plus partial enteral nutrition (PEN) in refractory pediatric UC where conventional therapy has failed, and the other was to explore the efficacy and safety of FMT plus PEN as first-line therapy for pediatric active UC
Inclusion: age of older than 2 years and younger than 16 years with no genetic diseases; as a first-line treatment group for UC, newly diagnosed with mild-to-moderate UC (defined by the PUCAI of >10 and≤64); In the refractory ulcerative colitis group, all refractory pediatric with mild-to-moderate UC (defined by the PUCAI of >10 and≤64) defined by children who failed conventional treatment (hormone, immunosuppressant, biologics); agree to received regularly colonoscopy.
Exclusion: Children who were treated by PEN (80%) less than 8 weeks; As a first-line treatment group for UC, patients who were treated with corticosteroids, methotrexate, thiopurines, and anti-TNF agents as their first-line treatment; Known contraindication to all FMT infusion method such as nasoduodenal tube insertion, oesophago-gastro-duodenoscopy (OGD), enteroscopy, colonoscopy, enema and Fecal capsule; Unwilling to give informed consent/ assent.