Tracking Brain Small Vessel Disease Over Time With Repeated Brain Scans
Follows adults at risk of brain small vessel disease using repeated MRI brain scans.
Plain-language title generated from the registry record
Registry title: Imaging the Pathogenesis of Cerebral Small Vessel Disease
Key facts
- Where
- Baltimore, United StatesSee the site
Where in United States
- Kennedy Krieger InstituteBaltimore, United StatesTaking people
Questions to ask the study team
- How often do I need to come in, and for how long each time?
- Are travel costs paid?
- Can I keep my own doctor?
- What happens if I want to stop?
Trial details
- Who runs it
- Johns Hopkins University
- Trial code
- NCT05703386
- Record updated
- 3 March 2026
- Original description
Cerebral small vessel disease (CSVD) can lead to vascular cognitive impairment and dementia (VCID). The hallmark of CSVD is the appearance and progression of white matter hyperintensities (WMH) on MRI. The goal of this study it to recruit and follow individuals at risk for WMH progression and use serial MRI scanning to gain insights into the pathogenesis of CSVD.Read full original descriptionShow less
Imaging the Pathogenesis of Cerebral Small Vessel Disease
Cerebral small vessel disease (CSVD) can lead to vascular cognitive impairment and dementia (VCID). The hallmark of CSVD is the appearance and progression of white matter hyperintensities (WMH) on MRI. The goal of this study it to recruit and follow individuals at risk for WMH progression and use serial MRI scanning to gain insights into the pathogenesis of CSVD.
Inclusion: Clinical or radiographic evidence of ischemic stroke; One vascular risk factor (hypertension, hyperlipidemia, or diabetes); Evidence of cerebral small vessel disease on MRI.
Exclusion: Inability to complete 3 research MRI scans over 1.25 years.