Investigation of the Neurovegetative Pattern in Patients With Thoracic Aortic Aneurysms (TAA)
Key facts
- Who runs it
- IRCCS Policlinico S. Donato
- Where
- Italy1 site in 1 countryChoose a country to see its sites
- Trial code
- Status
- Active, not recruiting
- People taking part
- 139 people, planned
- Started
- 9 Nov 2021
- Expected to end
- Jan 2027
- Type of study
- Observational, 2 groups
- Treatments tested
- Supine resting (REST) and active standing (STAND)
- Record updated
- 12 November 2026
Who can take part
- Age
- 18 years to 65 years
- Sex
- Women and men
- Healthy volunteers
- Cannot take part
The registry criteria, word for word
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Who can take part
- Patients aged 18-65 years with syndromic and nonsyndromic TAA
- Signed informed consent
- Patients on regular pharmacological prophylaxis (with Losartan) or naïve patients with a first diagnosis
Who cannot take part
- Acute and chronic inflammatory diseases such as: liver disease, chronic renal insufficiency (creatinine > 1.5 mg/dl) and diseases affecting the thyroid system
This trial has no sites in United States.
It has sites in one country. Choose a country to see its sites.
About the trial
What the trial wants to find out
The goal of this observational cross-sectional study is to learn about vagal features in patients with syndromic and non-syndromic TAA. The main question it aims to answer is to highlight a functional condition that could help stratify patients with TAA on the risk of aortic complications.
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Participant will take part by standing in supine position for 10 minutes and during active standing for 10 minutes. In this period of time, it will be possible to acquire the signals continuously and non invasively through recorded non-invasive blood pressure and piezoelectric sensor breathing belt.
The 2 groups in the trial
- Syndromic TAA
Patients presenting either clinical or genetic phenotype referring to a syndrome related to Thoracic Aortic Aneurysms
Treatment: Supine resting (REST) and active standing (STAND)
- Non-syndromic TAA
Patients presenting Thoracic Aortic Aneurysms
Treatment: Supine resting (REST) and active standing (STAND)
Data and sources
- Registry record
- Listed on ClinicalTrials.gov.
- Official title
- Investigation of the Neurovegetative Pattern in the Adult Population With Thoracic Aortic Aneurysms (AAT)
- Record updated
- 12 November 2026