Testing Two Oxygen Methods Before Hospital for COPD Flare-Ups
Compares oxygen dosing strategies in adults having a COPD flare-up before reaching hospital.
Plain-language title generated from the registry record
Registry title: Standard vs Targeted Oxygen Therapy Prehospital for Chronic Obstructive Pulmonary Disease
Key facts
- Where
- Aarhus N, DenmarkSee the site
- Phase
- Phase 4
Where in Denmark
- PræhospitaletAarhus N, DenmarkTaking people
Questions to ask the study team
- How often do I need to come in, and for how long each time?
- Are travel costs paid?
- Can I keep my own doctor?
- What happens if I want to stop?
Trial details
- Who runs it
- Central Denmark Region
- Trial code
- NCT05703919EU 2022-502003-30-00
- Record updated
- 2 October 2026
- Original description
The STOP-COPD trial is a randomized, patient-blinded, prehospital clinical trial designed to evaluate the effect of titrated oxygen therapy compared to standard oxygen treatment in patients with suspected acute exacerbation of chronic obstructive pulmonary disease (AECOPD) treated with inhaled bronchodilators. The primary objective is to determine whether a titrated oxygen strategy targeting SpO₂ 88-92% can reduce 30-day mortality compared to the current standard practice using 100% compressed oxygen as a nebulizer driver.Read full original descriptionShow less
Standard vs Targeted Oxygen Therapy Prehospital for Chronic Obstructive Pulmonary Disease
The STOP-COPD trial is a randomized, patient-blinded, prehospital clinical trial designed to evaluate the effect of titrated oxygen therapy compared to standard oxygen treatment in patients with suspected acute exacerbation of chronic obstructive pulmonary disease (AECOPD) treated with inhaled bronchodilators. The primary objective is to determine whether a titrated oxygen strategy targeting SpO₂ 88-92% can reduce 30-day mortality compared to the current standard practice using 100% compressed oxygen as a nebulizer driver.
Inclusion: Patients over the age of 40; EMT or Paramedic suspected AECOPD; Confirmed suspicion of COPD.
Exclusion: More than 2 doses (5 mg salbutamol) inhalation drug, acute treatment by EMS (emergency medical service) personnel, before allocated treatment is initiated; Bronchospasm due to asthma, allergic reaction or non-COPD conditions; Allergy to inhaled bronchodilators (Salbutamol); Suspicion of acute coronary syndrome; Known or suspected pregnancy; Prehospital Non-invasive, invasive or assisted bag mask ventilation; Inter-hospital transfer.