Effectiveness of Outpatient Intravenous Diuretic Therapy for Treatment of Worsening Heart Failure (OUTPATIENT-WHF)
Reason given: Study no longer moving forward
Key facts
- Where
- Durham, United StatesSee the site
Where in United States
- Duke University Medical CenterDurham, United StatesNo longer taking part
Trial details
- Who runs it
- Duke University
- Trial code
- NCT05704595
- Record updated
- 27 April 2025
- Original description
The purpose of the OUTPATIENT-WHF study is to characterize the effectiveness of outpatient intravenous diuretic therapy as a treatment for worsening heart failure.Read full original descriptionShow less
The purpose of the OUTPATIENT-WHF study is to characterize the effectiveness of outpatient intravenous diuretic therapy as a treatment for worsening heart failure.
Inclusion: ≥18 years of age; Presentation to a Duke outpatient clinic with heart failure requiring IV diuretics, as per clinician judgement; Able to provide signed informed consent; Successful completion of EuroQOL-5 dimensions survey.
Exclusion: Managing clinician without equipoise for initial outpatient treatment strategy versus initial hospitalization-based treatment strategy for heart failure, and decline to accept randomization; Patient without equipoise for initial outpatient treatment strategy versus initial hospitalization-based treatment strategy for heart failure, and decline to accept randomization; History of left ventricular assist device or heart transplantation; End-stage kidney disease requiring chronic dialysis therapy; New diagnosis of heart failure; Any other condition that in the judgment of the investigator would jeopardize the patient's compliance with the study protocol; Pregnant or breast-feeding; Fever >101.0 degrees Fahrenheit at screening.