CT-evaluation of Coronary Ostia Height After Surgical Aortic Valve Replacement.
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- Are you between 18 and 80 years old?
Source: NCT05714293, who can take part
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Print a page for my doctorTrial details
- Who runs it
- Fondazione Policlinico Universitario Agostino Gemelli IRCCS
- Trial code
- NCT05714293
- Record updated
- 15 August 2025
- Original description
The goal of this interventional, single-center study is to demonstrate if there is a change in the coronary ostia height after surgical aortic valve replacement and if it depends on the type of prosthesis or surgical technique used. The study involves patients undergoing elective surgical aortic valve replacement with a bioprosthesis. Participants enrolled will undergo a CT scan before and after surgery (at least 90 days after surgery) to analyze coronary ostia height.Read full original descriptionShow less
The goal of this interventional, single-center study is to demonstrate if there is a change in the coronary ostia height after surgical aortic valve replacement and if it depends on the type of prosthesis or surgical technique used. The study involves patients undergoing elective surgical aortic valve replacement with a bioprosthesis. Participants enrolled will undergo a CT scan before and after surgery (at least 90 days after surgery) to analyze coronary ostia height.
Inclusion: Age ≥ 18 years; Aortic valve stenosis or insufficiency with indication for elective aortic valve replacement with a bioprosthesis; Possible concomitant coronary artery disease with indication for surgical or percutaneous revascularization; CT imaging of the thorax with iodinated contrast agent carried out before surgery; Signed informed consent, inclusive of release of medical information.
Exclusion: Aortic valve replacement associated with surgery of ascending aorta/aortic root; Previous cardiac surgery of any kind; Aortic valve replacement associated with other cardiac valve surgery; Allergy or hypersensitivity to iodinated contrast agent; End-stage renal disease on dialysis; Aortic valve replacement in bicuspid valve or endocarditis; Patient unable to give informed consent or potentially noncompliant with the study protocol, in the judgment of the investigator; Participation in another clinical trial that could interfere with the endpoints of this study; Pregnant at time of screening.