Heart Inflammation Checked by MRI After Ischemic Stroke
Uses heart MRI and blood tests to look for heart inflammation in adults after stroke.
Plain-language title generated from the registry record
Registry title: MR Evidence of Cardiac Inflammation Post-Stroke
Key facts
- Where
- London, CanadaSee the site
Where in Canada
- Heart & Brain Lab, Western UniversityLondon, CanadaTaking people
Questions to ask the study team
- How often do I need to come in, and for how long each time?
- Are travel costs paid?
- Can I keep my own doctor?
- What happens if I want to stop?
Trial details
- Who runs it
- Luciano A. Sposato
- Trial code
- NCT05714618
- Record updated
- 18 September 2026
- Original description
The present study is an investigator initiated, single-centre, prospective, proof-of-concept cohort study aiming to enroll 44 patients with acute middle cerebral artery (MCA) ischemic stroke, involving the right (n=22) and left (n=22) MCA territories and 24 control patients with acute focal neurological symptoms but no evidence of acute brain infarct on DWI-MRI.Read full original descriptionShow less
Magnetic Resonance Imaging Evidence of Cardiac Inflammation Post-Stroke
The present study is an investigator initiated, single-centre, prospective, proof-of-concept cohort study aiming to enroll 44 patients with acute middle cerebral artery (MCA) ischemic stroke, involving the right (n=22) and left (n=22) MCA territories and 24 control patients with acute focal neurological symptoms but no evidence of acute brain infarct on DWI-MRI.
Inclusion: Acute ischemic stroke in the right or left MCA territory. Acute ischemic stroke is defined as acute onset focal symptoms matching an acute brain infarct documented on Head computed tomography or diffusion-weighted imaging (DWI) MRI of the brain showing restricted diffusion.
Exclusion: History of known atrial fibrillation, prior myocardial infarction, coronary artery disease, heart failure, prior cardiovascular surgery or percutaneous intervention; Previous stroke (occurred within 3 months before the index event); Ongoing infection or recent infection within the previous 3 months; Surgery within 3 months before the stroke; Concurrent and active inflammatory conditions (connective tissue diseases, rheumatological disease, etc.) or use of anti-inflammatory medications; hs-TnT >100 on routine acute stroke baseline bloodwork upon admission; Stroke with symptomatic hemorrhagic transformation; Subjects will be excluded if they fail the LHSC standard MRI screening questionnaire (cardiac pacemakers/wires, aneurysm clips, shunt/surgical clips, shrapnel/bullets, dentures or metal braces, intra-uterine devices, heart valves, ear implants, prostheses, medication patches such as Nicoderm, Habitrol, or Transderm-Nitro, claustrophobia, history of a head or eye injury involving metal fragments; Impaired renal function defined as a creatinine clearance <97 mL/min in men or <88 mL/min in women, according to the Cockcroft formula; Pregnancy, Stage IV renal insufficiency, eGFR <30, and any other contraindications to the use of gadolinium; Clinically or neurologically unstable patients as per the treating physician.