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Aortic Stiffness in Patients With Genetic Aortopathies

Key facts

Who runs it
IRCCS Policlinico S. Donato
Where
Italy1 site in 1 countryChoose a country to see its sites
Trial code
Status
Recruiting
People taking part
250 people, planned
Started
15 Feb 2023
Expected to end
31 Dec 2027
Type of study
Observational, 2 groups
Treatments tested
  • Pulsotonometry
Record updated
10 November 2026

Who can take part

Sex
Women and men

The registry criteria, word for word

Show all 6 criteriaShow less

Who can take part

  • Subjects with AAT, either syndromic or non syndromic
  • Signed informed consent

Who cannot take part

  • Patients with early menopause and/or osteoporosis, rheumatic heart disease and active malignant tumours
  • Patients with acute and chronic inflammatory conditions such as: chronic liver disease, chronic renal insufficiency and diseases affecting the thyroid system
  • Seropositivity to HIV, HCV, HBsAg and SARS-CoV-2
  • Pregnancy

This trial has no sites in United States.

It has sites in one country. Choose a country to see its sites.

About the trial

What the trial wants to find out

The goal of this observational study is to study arterial stiffness in patients with thoracic ascending aortic aneurysms (TAA), either syndromic or non-syndromic. The main questions it aims to answer are:

Read full original descriptionShow less

* Stratification of aortic risk based on arterial stiffness; Compare measurements with morphological and haemodynamic features of the ascending thoracic aorta.

Participants will be asked to undergo non-invasive evaluation of blood pressure and arterial stiffness.

The 2 groups in the trial

  • Syndromic TAA

    Subjets with clinical or genetic diagnosis of syndromic thoracic aortic aneurysms

    Treatment: Pulsotonometry

  • Non-syndromic TAA

    Subjets without clinical or genetic diagnosis of syndromic thoracic aortic aneurysms

    Treatment: Pulsotonometry

Questions to ask the study team

  1. How often do I need to come in, and for how long each time?
  2. Are travel costs paid?
  3. Can I keep my own doctor?
  4. What happens if I want to stop?

Contact the study team: see the registry record → Contacts and Locations

Print a page for my doctor

Data and sources

Registry record
Listed on ClinicalTrials.gov.
Official title
Aortic Stiffness in Patients With Genetic Aortopathies: Intervention Analysis
Record updated
10 November 2026