Aortic Stiffness in Patients With Genetic Aortopathies
Key facts
- Who runs it
- IRCCS Policlinico S. Donato
- Where
- San Donato Milanese, ItalySee the site
- Trial code
- Status
- Recruiting
- People taking part
- 250 people, planned
- Started
- 15 Feb 2023
- Expected to end
- 31 Dec 2027
- Type of study
- Observational, 2 groups
- Treatments tested
- Pulsotonometry
- Record updated
- 10 November 2026
Who can take part
- Sex
- Women and men
The registry criteria, word for word
Show all 6 criteriaShow less
Who can take part
- Subjects with AAT, either syndromic or non syndromic
- Signed informed consent
Who cannot take part
- Patients with early menopause and/or osteoporosis, rheumatic heart disease and active malignant tumours
- Patients with acute and chronic inflammatory conditions such as: chronic liver disease, chronic renal insufficiency and diseases affecting the thyroid system
- Seropositivity to HIV, HCV, HBsAg and SARS-CoV-2
- Pregnancy
Where in Italy
- IRCCS Policlinico San DonatoSan Donato Milanese, ItalyContact: Alessandro Pini, MDTaking people
About the trial
What the trial wants to find out
The goal of this observational study is to study arterial stiffness in patients with thoracic ascending aortic aneurysms (TAA), either syndromic or non-syndromic. The main questions it aims to answer are:
Read full original descriptionShow less
* Stratification of aortic risk based on arterial stiffness; Compare measurements with morphological and haemodynamic features of the ascending thoracic aorta.
Participants will be asked to undergo non-invasive evaluation of blood pressure and arterial stiffness.
The 2 groups in the trial
- Syndromic TAA
Subjets with clinical or genetic diagnosis of syndromic thoracic aortic aneurysms
Treatment: Pulsotonometry
- Non-syndromic TAA
Subjets without clinical or genetic diagnosis of syndromic thoracic aortic aneurysms
Treatment: Pulsotonometry
Questions to ask the study team
- How often do I need to come in, and for how long each time?
- Are travel costs paid?
- Can I keep my own doctor?
- What happens if I want to stop?
Contact the study team: see the registry record → Contacts and Locations
Print a page for my doctorData and sources
- Registry record
- Listed on ClinicalTrials.gov.
- Official title
- Aortic Stiffness in Patients With Genetic Aortopathies: Intervention Analysis
- Record updated
- 10 November 2026