Taking people in GermanyPhase 2

Adds niraparib to maintenance immunotherapy in small cell lung cancer

Tests adding niraparib to anti-PD-L1 maintenance in adults with extensive small cell lung cancer.

Plain-language title generated from the registry record
Registry title: Niraparib Added to Anti-PD-L1 Antibody Maintenance in SLFN11-positive, Extensive-disease SCLC

Key facts

Where: Munich, GermanySee the site
Phase: Phase 2

AI summary: who the study is looking for

From the trial's eligibility criteria. Machine-read from the registry text on this page, so it can be wrong. The registry text below and the trial team decide who can take part.

The trial is looking for adults with extensive-stage small cell lung cancer whose tumour has high SLFN11 and has not grown after first-line chemo-immunotherapy. Niraparib is added to anti-PD-L1 antibody maintenance.

Age: 18 years or older.
Sex: All sexes can join.
Disease stage: Extensive-stage small cell lung cancer (stage IV). It must not have grown during or after first-line chemo-immunotherapy.
Earlier treatment: Must have had 4 cycles of platinum-etoposide chemotherapy together with an anti-PD-L1 antibody (atezolizumab or durvalumab). Must be able to continue maintenance with an immune-checkpoint inhibitor.
Biomarker or test result: High SLFN11 in tumour tissue: protein found in at least 20% of tumour cells, tested at the central laboratory.

Main reasons for not taking part

Brain metastases that cause symptoms
Another active cancer (a few low-risk cancers are allowed)
Past lung scarring or lung inflammation (pneumonitis), or lung disease needing steroids above 10 mg prednisolone
Past myelodysplastic syndrome or acute myeloid leukemia
Pregnant or breastfeeding

Read by machine on 12 November 2026.

Where in Germany

LMU Klinikum Muenchen AöRMunich, GermanyTaking people

Questions to ask the study team

How often do I need to come in, and for how long each time?
Are travel costs paid?
Can I keep my own doctor?
What happens if I want to stop?

Contact the study team: see the registry record → Contacts and Locations

Print a page for my doctor

Trial details

Who runs it: ETOP IBCSG Partners Foundation
Trial code: NCT05718323 EU 2022-502092-33-00
Record updated: 29 May 2026
Original description: RAISE is an international, multicentre, single-arm phase II trial. The trial treatment consists of the addition of niraparib, 200 mg orally once daily to anti-PD-L1 antibody maintenance. The primary objective of this trial is to assess the clinical efficacy of the addition of niraparib to anti-PD-L1 monoclonal antibody maintenance treatment in patients with SLFN11-positive ED-SCLC which has not progressed following standard first-line chemo-immunotherapy.Read full original descriptionShow less
A Single-arm Phase II Trial of the Addition of Niraparib to Anti-PD-L1 Antibody Maintenance in Patients With SLFN11-positive, Extensive-disease Small Cell Lung Cancer.
RAISE is an international, multicentre, single-arm phase II trial. The trial treatment consists of the addition of niraparib, 200 mg orally once daily to anti-PD-L1 antibody maintenance. The primary objective of this trial is to assess the clinical efficacy of the addition of niraparib to anti-PD-L1 monoclonal antibody maintenance treatment in patients with SLFN11-positive ED-SCLC which has not progressed following standard first-line chemo-immunotherapy.
Inclusion: Written IC part 1: for SLFN11-screening must be signed and dated by the patient and the investigator prior to sending any tumour material to the central laboratory; Histologically or cytologically confirmed ED-SCLC (stage IV according to the 8th TNM classification); Availability of FFPE tumour tissue for screening; Written IC part 2: for trial participation must be signed and dated by the patient and the investigator prior to any trial-related intervention; High SLFN11-expression on FFPE tumour material:; SLFN11-expression is determined at the central screening laboratory in Basel. Overexpression is defined as detectable protein expression by IHC in ≥20% of tumour cells; Patients must have received standard first-line chemo-immunotherapy, consisting of 4 cycles of platinum-etoposide chemotherapy in combination with an anti-PD-L1 antibody (atezolizumab or durvalumab). Patients who started the immunotherapy at chemotherapy cycle 2 are eligible; ED-SCLC must not have progressed during or after standard chemo-immunotherapy (as per RECIST v1.1); Patients must be candidates for ongoing maintenance treatment with immune-checkpoint inhibition; Adequate haematological function:; Adequate renal function:; Adequate liver function:; ECOG PS 0-2; Age ≥18 years; Women of childbearing potential, including women who had their last menstruation in the last 2 years, must have a negative urinary or serum pregnancy test within 4 weeks before enrolment and within 3 days before treatment start.
Exclusion: Any serious concomitant systemic disorders (for example active infection, unstable cardiovascular disease) which in the opinion of the investigator would compromise the patient's ability to complete the trial or interfere with the evaluation of the efficacy and safety of the protocol treatment; Prior Reversible Encephalopathy Syndrome (PRES); Treated with live vaccine within 30 days before enrolment; Any clinically active cancer, other than SCLC Exception: malignancies with negligible risk of metastases or death (e.g. 5-year OS rate of >90%), such as adequately treated carcinoma in situ of the cervix, non-melanoma skin carcinoma, localised prostate cancer, ductal carcinoma in situ, or stage I uterine cancer. Hormonal therapy for non-metastatic prostate or ductal carcinoma in situ is allowed; Consolidating thoracic radiotherapy. Palliative radiotherapy to the brain or to bones is allowed; History of idiopathic pulmonary fibrosis, organising pneumonia (e.g., bronchiolitis obliterans), drug-induced pneumonitis, or idiopathic pneumonitis, or evidence of active pneumonitis on screening chest computed tomography (CT) scan; Any lung disease requiring systemic steroids in doses of >10 mg prednisolone (or equivalent dose of other steroid); Inadequately controlled hypertension, defined as systolic blood pressure >150 mmHg and/or diastolic blood pressure >95 mmHg; The patient must be considered stable and hypertension medically controlled; History of myelodysplastic syndrome/acute myeloid leukemia (MDS/AML); Severe renal or hepatic impairment; Any clinically significant gastrointestinal (GI) abnormalities that may alter absorption such as malabsorption syndrome or major resection of the stomach and/or bowels; Hypersensitivity to niraparib or any of its excipients (e.g., tartrazine); Symptomatic brain metastases; Women who are pregnant or in the period of lactation; Sexually active men and women of childbearing potential who are not willing to use an effective contraceptive method during the trial and within the required timelines after last dose of niraparib treatment; Judgment by the investigator that the patient is unlikely to comply with trial procedures, restrictions and requirements.
ClinicalTrials.gov NCT05718323 · EU CTIS 2022-502092-33-00