Lung cancer screening with low-dose CT scans and biomarker sampling in Singapore
Tests low-dose chest CT and biomarker sampling to screen adults for lung cancer.
Plain-language title generated from the registry record
Registry title: SingapOre Lung Cancer Screening Through Integrating CT With Other biomarkErs (SOLSTICE)
Key facts
- Where
- Singapore, SingaporeSee the 6 sites
Could this be for you?
Answer for yourself. This is not a decision: only the study team can say whether you can take part.
- Are you between 50 and 80 years old?
Source: NCT05724264, who can take part
Where in Singapore
- Changi General Hospital, SingaporeSingapore, SingaporeTaking people
- National Cancer Centre SingaporeSingapore, SingaporeTaking people
- Sengkang General Hospital, SingaporeSingapore, SingaporeTaking people
- Singapore General HospitalSingapore, SingaporeTaking people
- Tan Tock Seng Hospital, SingaporeSingapore, SingaporeTaking people
- National Heart Centre SingaporeSingapore, SingaporeNo longer taking part
Questions to ask the study team
- How often do I need to come in, and for how long each time?
- Are travel costs paid?
- Can I keep my own doctor?
- What happens if I want to stop?
Trial details
- Who runs it
- National Cancer Centre, Singapore
- Trial code
- NCT05724264
- Record updated
- 15 May 2026
- Original description
This is a single arm screening study. All eligible participants will be subjected to low dose CT (LDCT) screening and biomarker testing.Read full original descriptionShow less
SingapOre Lung Cancer Screening Through Integrating CT With Other biomarkErs (SOLSTICE)
This is a single arm screening study. All eligible participants will be subjected to low dose CT (LDCT) screening and biomarker testing.
The primary aim of the study is to determine the feasibility of conducting LDCT screening in at-risk populations for lung cancer in Singapore:
* For the smoker population, LDCT screening for lung cancer will be implemented in accordance to Academy of Medicine, Singapore screening test guidelines with the aim of investigating the feasibility of instituting lung cancer screening clinical service in Singapore. * For the non-smoker population, LDCT screening for lung cancer will be introduced to systematically collect baseline data to better understand and provide evidence for lung adenocarcinoma in never-smoker phenotype that is unique to East Asia/Singapore. This will help address unmet needs in local population research as reported by Academy of Medicine, Singapore, to validate risk factors and inform future screening guidelines for the at-risk population.
Screening results will be reported based on Lung CT Screening Reporting \& Data System (Lung-RADS).
Inclusion: Smoker:; Participant is willing and able to give informed consent for participation in the study; Male or female, aged 50-80 years of age; No prior history of cancer, or cancer free in the last 5 years and not currently on cancer treatment; ECOG 0/1; Current or former smokers with at least 30 pack years of smoking history; Willing to comply with study follow-up schedule and tests; Willing to cover the costs of downstream standard of care management and investigations including doctor's fee, CT scan and biopsy etc; A Singapore citizen/Permanent Resident of Singapore; Non-Smoker:; Participant is willing and able to give informed consent for participation in the study; Male, or female, aged 50-80 years of age; No prior history of cancer, or cancer free in the last 5 years and not currently on cancer treatment; ECOG 0/1; Never smoker, or has smoked less than 10 pack-years and has quit smoking for at least 15 years; Family history of lung cancer up to 2nd degree relatives; Willing to comply with study follow-up schedule and tests; Willing to cover the costs of downstream standard of care management and investigations including doctor's fee, CT scan and biopsy etc; A Singapore citizen/Permanent Resident of Singapore.
Exclusion: Previous diagnosis of cancer; Bleeding diathesis that will preclude blood sampling; Uncontrolled medical comorbidity on enrolment; Fear of blood draw or needles; Pregnancy.