Studies bone cells and bone health in people having orthopaedic surgery
Collects surgical bone waste from adults to study bone disease causes.
Key facts
- Who runs it
- Relation Therapeutics
- Where
- London, United KingdomSee the 8 sites
- Trial code
- Registry title
- OSTEOMICS: Identifying Regulators of Bone Homeostasis
- Status
- Recruiting
- People taking part
- 2,000 people, planned
- Started
- 12 Jan 2023
- Expected to end
- Dec 2032
- Type of study
- Observational
- Treatments tested
- Relevant orthopaedic surgery
- Record updated
- 14 August 2026
Who can take part
AI summary
From the trial's eligibility criteria. Machine-read from the registry text on this page, so it can be wrong. The registry text below and the trial team decide who can take part.
The trial is looking for adults having orthopaedic surgery for osteoarthritis or a bone fracture. Bone removed during surgery is studied to learn how bone stays healthy.
- Age
- 18 to 110 years old
- Sex
- All sexes can join.
- Disease stage
- Osteoarthritis needing joint replacement, bone cutting or joint fusion. Broken neck of the thigh bone needing surgery. Sudden low-impact or fragility fractures needing fixation surgery.
Main reasons for not taking part
- Cannot give informed consent
- Suspected or confirmed cancer in the bone area
- Suspected or confirmed bone infection (osteomyelitis)
- Suspected or confirmed blood-borne disease
- Currently in a trial of an investigational medicine
The registry criteria, word for word
Show all 9 criteriaShow less
Who can take part
- Patients with osteoarthritis undergoing total joint arthroplasty, osteotomy or arthrodesis of any joint (including hip, knee, shoulder, wrist, elbow, ankle)
- Patient with fractured neck of femurs undergoing hemiarthroplasty or total hip arthroplasty, or other internal fixation procedure
- Patients undergoing acute low-velocity or fragility fracture fixation surgery
- Patients aged between 18-110 years old with capacity to consent; Since deteriorating bone health including diseases like osteoporosis are primarily conditions of older age there is no practical upper age-limit. However, study involvement is limited by suitability for surgery which encompasses multiple factors considered on an individual case basis including age, frailty, comorbidities, baseline mobility, renal function and ability to consent (for instance due to dementia or delirium); We note that our inclusion criteria is purposefully broad as we aim to deduce trends across a wide range of conditions and backgrounds
Who cannot take part
- Patients with suspected/established underlying malignancy
- Patients with suspected/established bloodborne disease
- Patients unable to provide informed consent
- Patients with suspected/established osteomyelitis
- Patients who are currently a subject of a clinical trial involving an investigational medicinal product
Check if you might fit
Answer for yourself. This is not a decision: only the study team can say whether you can take part.
- Are you between 18 and 110 years old?
Where in United Kingdom
- Barts Health NHS TrustLondon, United KingdomContact: Catherine HiltonTaking people
- Chase Farm HospitalLondon, United KingdomContact: Olaoluwa OlaosebikanTaking people
- Fitzrovia Hospital/QASMCLondon, United KingdomContact: Nazish DaudiTaking people
- King's College HospitalLondon, United KingdomContact: Kerim GokturkNot yet recruiting
- Royal National Orthopaedic Hospital NHS TrustLondon, United KingdomContact: Richard KeenNot yet recruiting
- West Middlesex University HospitalLondon, United KingdomContact: Amrinder SayanTaking people
- Harley Street Specialist HospitalLondon, United KingdomContact: Jake Taylor-King, DPhilNo longer taking part
- Luton & Dunstable University HospitalLondon, United KingdomContact: Jake Taylor-King, DPhilNo longer taking part
About the trial
What the trial wants to find out
Diseases of bone associated with ageing, including osteoporosis (OP) and osteoarthritis (OA), reduce bone mass, bone strength and joint integrity. Current non-surgical approaches are limited to pharmaceutical agents that are not disease modifying and have poor patient tolerability due to side effect profiles. Developing a fundamental understanding of cellular bone homeostasis, including how key cell types affect tissue health, and offering novel therapeutic targets for prevention of bone disease is therefore essential. This is the focus of OSTEOMICS.
Read full original descriptionShow less
A number of factors have been linked to increased risk of bone disease, including genetic predisposition, diet, smoking, ageing, autoimmune disorders and endocrine disorders. In our study, we will recruit patients undergoing elective and non-elective orthopaedic surgery and obtain surgical bone waste for analysis. This will capture a cohort of patients with bone disorders like OP and OA, in addition to patients without overt clinical bone disease. We will study the relationship between the molecular biology of bone cells, bone structure, genetics (DNA) and environmental factors with the aim of identifying and validating novel therapeutic targets.
We will leverage modern single cell technologies to understand the diversity of cell types found in bone. These technologies have now led to the characterisation of virtually every tissue in the body, however bone and bone-adjacent tissues are massively underrepresented due to the anatomical location and underlying technical challenges. Early protocols to demineralise bone and perform single cell profiling have now been developed. We will systematically scale up these efforts to observe how genetic variation at the population level leads to alterations in bone structure and quality.
Over the next 10 years, we will generate data to comprehensively characterise bone across health and disease, use machine learning to drive analysis, and experimentally validate hypotheses - which will ultimately contribute to developing the next generation of therapeutic agents.
The group in the trial
- Participant undergoing orthopaedic surgery
* Patients with osteoarthritis undergoing total joint arthroplasty, osteotomy or arthrodesis of any joint (including hip, knee, shoulder, elbow, ankle). * Patients with fractured neck of femurs undergoing hemiarthroplasty or total hip arthroplasty, or other internal fixation procedure. * Patients undergoing acute low-velocity or fragility fracture fixation surgery.
Treatment: Relevant orthopaedic surgery
Questions to ask the study team
- How often do I need to come in, and for how long each time?
- Are travel costs paid?
- Can I keep my own doctor?
- What happens if I want to stop?
Contact the study team: see the registry record → Contacts and Locations
Print a page for my doctorData and sources
- Registry record
- Listed on ClinicalTrials.gov.
- Official title
- OSTEOMICS: Identifying Regulators of Bone Homeostasis
- Plain-language title
- Studies bone cells and bone health in people having orthopaedic surgeryGenerated from the registry record. The registry title is the official one.
- AI summary
- From the trial's eligibility criteria. Read by machine on 12 November 2026.
- Fit questions
- Built from NCT05732870, who can take part
- Record updated
- 14 August 2026