Studies nerve involvement in the autonomic nervous system in multiple sclerosis
Tests how multiple sclerosis affects autonomic nerves, using skin biopsies and heart reflex tests.
Plain-language title generated from the registry record
Registry title: Definition of Autonomic Nervous System Involvement in Patients With Multiple Sclerosis
Key facts
- Where
- Naples and Telese Terme, ItalySee the 2 sites
Where in Italy
- Department of Neurosciences, Reproductive Sciences and Odontostomatology, University of Naples Federico IINaples, ItalyTaking people
- ICS Maugeri - IRCCS of Telese TermeTelese Terme, ItalyTaking people
Questions to ask the study team
- How often do I need to come in, and for how long each time?
- Are travel costs paid?
- Can I keep my own doctor?
- What happens if I want to stop?
Trial details
- Who runs it
- Istituti Clinici Scientifici Maugeri SpA
- Trial code
- NCT05748015
- Record updated
- 17 April 2026
- Original description
The goal of this interventional non-pharmacological study is to evaluate the involvement of the autonomic nervous system in patients with relapsing-remitting and primary progressive multiple sclerosis.Read full original descriptionShow less
Definition of Autonomic Nervous System Involvement in Patients With Relapsing-remitting and Primary Progressive Multiple Sclerosis
The goal of this interventional non-pharmacological study is to evaluate the involvement of the autonomic nervous system in patients with relapsing-remitting and primary progressive multiple sclerosis.
The main questions it aims to answer are:
* Is it possible to define the characteristics of dysautonomia to improve treatment on patients with multiple sclerosis through the management of conditions such as orthostatic hypotension or thermoregulation disorders that inevitably condition the patient's life and the response to rehabilitation ? * Does the severity of the functional alterations correlate with impairment of small somatic and autonomic cutaneous nerve fibers in patients with multiple sclerosis ? * How much the involvement of the autonomic nervous system affects the clinical history and progression of the disease ? * Do different clinical variants of multiple sclerosis manifest with different patterns of involvement of the sensory-autonomic nervous system ?
Participants will be hospitalized in Maugeri Clinical Institute of Telese Terme for a rehabilitation treatment. Patients will perform a sensory and autonomic functional study and a morphological analysis of cutaneous nerves through skin biopsy.
Researchers will compare results between the two groups (relapsing-remitting and primary progressive) and between patients and data from control subjects.
Inclusion: diagnosis of relapsing-remitting and primary progressive multiple sclerosis.
Exclusion: assumption of potentially neurotoxic substances or drugs; known other neurological disorders; other forms of multiple sclerosis,.