Studies pain and autonomic symptoms in Parkinson disease and multiple system atrophy
Observes pain, autonomic symptoms and rehabilitation effects in adults with Parkinson disease or MSA.
Plain-language title generated from the registry record
Registry title: Pain and Autonomic Symptoms in Parkinson's Disease and Atypical Parkinsonisms
Key facts
- Where
- Castel Goffredo, Lumezzane, Milan, Mistretta, Montescano, Pavia, Telese Terme, and Veruno, ItalySee the 9 sites
AI summary: who the study is looking for
From the trial's eligibility criteria. Machine-read from the registry text on this page, so it can be wrong. The registry text below and the trial team decide who can take part.
The trial is looking for adults with Parkinson's disease or multiple system atrophy (MSA) who are admitted to Maugeri centres. It studies pain and autonomic symptoms and the effect of rehabilitation.
- Age
- 18 years or older
- Sex
- All sexes can join.
- Disease stage
- Clinical diagnosis of Parkinson's disease or multiple system atrophy by current international criteria.
- Biomarker or test result
- Mini-Mental State Examination score of at least 10.
Main reasons for not taking part
- Vascular or pharmacological parkinsonism
- Diabetes mellitus
- Liver or kidney metabolic disorder
- Underactive or overactive thyroid
- Taking drugs that may harm the nerves
Read by machine on 12 November 2026.
Where in Italy
- ICS Maugeri - CastelgoffredoCastel Goffredo, ItalyContact: Giuliana Vezzadini, MDTaking people
- ICS Maugeri - LumezzaneLumezzane, ItalyContact: Diego Ghianda, MDTaking people
- ICS Maugeri - MilanoMilan, ItalyContact: Beatrice De Maria, EngTaking people
- ICS Maugeri - MistrettaMistretta, ItalyContact: Paolo Volanti, MDTaking people
- ICS Maugeri - MontescanoMontescano, ItalyContact: Cira Fundarò, MDTaking people
- ICS Maugeri - PaviaPavia, ItalyContact: Isabella Springhetti, MDTaking people
- ICS Maugeri - Pavia BoezioPavia, ItalyContact: Marianna Loi, MDTaking people
- ICS Maugeri - IRCCS of Telese TermeTelese Terme, ItalyContact: Vincenzo Provitera, MDTaking people
- ICS Maugeri - VerunoVeruno, ItalyContact: Giorgio Maggioni, MDTaking people
Questions to ask the study team
- How often do I need to come in, and for how long each time?
- Are travel costs paid?
- Can I keep my own doctor?
- What happens if I want to stop?
Contact the study team: see the registry record → Contacts and Locations
Print a page for my doctorTrial details
- Who runs it
- Istituti Clinici Scientifici Maugeri SpA
- Trial code
- NCT05748028
- Record updated
- 17 April 2026
- Original description
The goal of this observational study is to learn about the impact of the different types of pain and of the domains involved in the autonomic disorders of inpatients and outpatients diagnosed with Parkinson disease (PD) and multiple system atrophy (MSA) admitted to Istituti Clinici Scientifici Maugeri Centers.Read full original descriptionShow less
Pain and Autonomic Symptoms in Parkinson's Disease and Atypical Parkinsonisms: Identification of Predictive Patterns of Rehabilitation Outcome and Evaluation of the Impact on Quality of Life
The goal of this observational study is to learn about the impact of the different types of pain and of the domains involved in the autonomic disorders of inpatients and outpatients diagnosed with Parkinson disease (PD) and multiple system atrophy (MSA) admitted to Istituti Clinici Scientifici Maugeri Centers.
The main aims are:
Evaluate the prevalence of pain and characterize it in Parkinson's disease and atypical parkinsonisms (MSA) Evaluate the effect of rehabilitation on pain and autonomic symptoms Evaluate the prevalence of autonomic symptoms in Parkinson's disease and atypical parkinsonisms (MSA) Assess the impact of pain and autonomic symptoms on quality of life. Participants will perform neurological examination, rehabilitation program and clinical scales.
Researchers will compare the two groups of patients (PD and MSA) and the effect of the rehabilitation on pain, autonomic symptoms and quality of life.
Inclusion: Clinical diagnosis of Parkinson's Disease or Multiple System Atrophy according to current international criteria (Gilman S et al, 2008; Postuma RB et al. 2015); Mini-Mental State Examination score at least 10.
Exclusion: assumption of potentially neurotoxic drugs; diabetes mellitus; vascular or pharmacological parkinsonism; hepatic or renal dysmetabolism,; hypothyroidism or hyperthyroidism.