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Blood thinner management around childbirth in women with blood clots

Follows pregnant women with venous thromboembolism to see how anticoagulants are managed around delivery.

Key facts

Who runs it
University of Calgary
Where
Durham, United StatesSee the siteAlso in 4 other countries, 13 sites
Trial code
Registry title
PRospective Evaluation of Peripartum Anticoagulation ManaGement for ThrOmboembolism
Status
Recruiting
People taking part
825 people, planned
Started
4 Apr 2023
Expected to end
31 Dec 2029
Type of study
Observational
Record updated
28 November 2025

Who can take part

AI summary

From the trial's eligibility criteria. Machine-read from the registry text on this page, so it can be wrong. The registry text below and the trial team decide who can take part.

The trial is looking for pregnant women who need blood thinners for blood clots in veins (VTE). It follows how blood thinners are handled around labor, delivery and after birth.

Age
18 to 60 Years
Sex
Women only
Disease stage
A blood clot in a vein (DVT, superficial vein clot, lung clot (PE) or a clot in an unusual site), confirmed by tests, in this pregnancy, a past pregnancy or when not pregnant. Or an inherited or acquired clotting disorder (thrombophilia) that needs blood thinners.
Earlier treatment
Must be getting any dose or type of LMWH (a blood thinner given by injection) during pregnancy, before delivery.

Main reasons for not taking part

  • Blood thinners for another reason, such as artificial heart valves or atrial fibrillation
  • Blood thinners only to prevent placenta problems or repeated pregnancy loss (people with antiphospholipid syndrome (APS) can join)
  • Planned delivery at home or in a birthing centre
  • Unable to give consent or declined consent

This trial only enrols pregnant participants. The registry sentence this rests on: Requires anticoagulation during the antepartum period of pregnancy for a VTE indication, including at least one of:

The registry criteria, word for word

Show all 6 criteriaShow less

Who can take part

  • 18 years of age or older
  • Requires anticoagulation during the antepartum period of pregnancy for a VTE indication, including at least one of:; Objectively confirmed VTE (DVT, superficial vein thrombosis [SVT], PE or unusual site thrombosis) diagnosed during the current pregnancy; Objectively confirmed VTE diagnosed in a prior pregnancy; Objectively confirmed VTE diagnosed when not pregnant; Inherited or acquired thrombophilia requiring anticoagulation
  • Receiving any dose or type of LMWH during the antepartum period

Who cannot take part

  • Anticoagulation for a non-VTE indication, including prosthetic heart valves, atrial fibrillation, prevention of placenta-mediated pregnancy complications, or prevention of recurrent pregnancy loss (participants can be included with a diagnosis of antiphospholipid syndrome (APS) with or without thrombotic events)
  • Unable to provide or declined consent
  • Home or birthing centre planned delivery

Check if you might fit

Answer for yourself. This is not a decision: only the study team can say whether you can take part.

  • Are you between 18 and 60 years old?

Where in United States

Also in 4 other countries, 13 sites

  • Duke University HospitalDurham, United StatesContact: Danielle LanpherTaking people

About the trial

What the trial wants to find out

The PREP and GO study is an international multicentre prospective cohort evaluating anticoagulation management strategies around labor and delivery and the postpartum period.

Questions to ask the study team

  1. How often do I need to come in, and for how long each time?
  2. Are travel costs paid?
  3. Can I keep my own doctor?
  4. What happens if I want to stop?

Contact the study team: see the registry record → Contacts and Locations

Print a page for my doctor

Data and sources

Registry record
Listed on ClinicalTrials.gov.
Official title
A Prospective Cohort Study Evaluating Peripartum Anticoagulation Management Among Pregnant Women With Venous Thromboembolism and Its Impact on Patient Outcomes
Plain-language title
Blood thinner management around childbirth in women with blood clotsGenerated from the registry record. The registry title is the official one.
AI summary
From the trial's eligibility criteria. Read by machine on 15 November 2026.
Fit questions
Built from NCT05756244, who can take part
Record updated
28 November 2025