Blood Pressure Swings and Recovery After Acute Ischemic Stroke
Observes how blood pressure variability relates to recovery in adults with acute ischemic stroke.
Plain-language title generated from the registry record
Registry title: Blood Pressure Variability and Ischemic Stroke Outcome
Key facts
- Where
- Boston, Chicago, and New Haven, United StatesSee the 3 sites
Where in United States
- Massachusetts General HospitalBoston, United StatesTaking people
- University of Chicago Medical CenterChicago, United StatesTaking people
- Yale New Haven HospitalNew Haven, United StatesTaking people
Questions to ask the study team
- How often do I need to come in, and for how long each time?
- Are travel costs paid?
- Can I keep my own doctor?
- What happens if I want to stop?
Trial details
- Who runs it
- Yale University
- Trial code
- NCT05756257
- Record updated
- 28 September 2026
- Original description
The goal of this observational study is to evaluate the role of blood pressure (BPV) variability in patients suffering from acute ischemic stroke. The main questions it aims to answer are:Read full original descriptionShow less
Blood Pressure Variability and Ischemic Stroke Outcome
The goal of this observational study is to evaluate the role of blood pressure (BPV) variability in patients suffering from acute ischemic stroke. The main questions it aims to answer are:
1. To determine the association of BPV with functional/cognitive outcome after ischemic stroke. 2. To determine a pathophysiologic mechanism of BPV's deleterious effect on functional outcome. 3. To evaluate potential treatment targets to pharmacologically reduce BPV after ischemic stroke.
Inclusion: Ischemic stroke according to the American Heart Association (AHA) definition and either:; CT or MRI showing ischemic stroke in the anterior circulation (frontal, parietal or superior temporal lobes), or; Occlusion of the internal carotid, middle cerebral or anterior cerebral arteries on computed tomography angiography (CTA) or magnetic resonance angiography (MRA); Onset of ischemic stroke within 48 hours and able to get baseline pMRI within 72 hours of arrival; NIH Stroke Scale ≥ 4 at time of enrollment.
Exclusion: Pre-morbid mRS ≥3; Predicted hospital system admission <72 hours; Pacemaker or other MRI contraindications per American College of Radiology guidelines.