Tests a modified MMR vaccine schedule in infants for infections and allergies
Tests a modified MMR vaccine schedule in 6-month-old children for infections and allergies.
Plain-language title generated from the registry record
Registry title: Non-specific Effects of a Modified Measles Vaccination Schedule to Prevent Allergy and Unrelated Infection in Children
Key facts
- Where
- Geneva, SwitzerlandSee the site
- Phase
- Phase 4
Where in Switzerland
- University Hospitals of GenevaGeneva, SwitzerlandTaking people
Questions to ask the study team
- How often do I need to come in, and for how long each time?
- Are travel costs paid?
- Can I keep my own doctor?
- What happens if I want to stop?
Trial details
- Who runs it
- Laure Pittet, MD-PhD
- Trial code
- NCT05758532
- Record updated
- 29 May 2024
- Original description
The goal of this clinical trial is to evaluate the off-target/non-specific effects of the measles-mumps-rubella (MMR) vaccine in children.Read full original descriptionShow less
Harnessing the Beneficial Non-specific Effects of Measles-mumps-rubella Vaccine in Children on Infection With Unrelated Pathogens and Allergic Diseases - a Single-centre Phase IV RCT With a Factorial Design
The goal of this clinical trial is to evaluate the off-target/non-specific effects of the measles-mumps-rubella (MMR) vaccine in children.
Inclusion: Informed Consent as documented by signature; 6-month-old children; In overall good health, without any clinically significant concomitant disease states (e.g., renal failure, hepatic dysfunction, cardiovascular disease, etc.) and no clinically significant abnormal finding on history and/or physical examination; Fully immunised for age according to the Swiss vaccination schedule; with at least 2 doses of DTP-containing vaccine; the last dose of vaccine received at least 2 weeks prior to enrolment.
Exclusion: Contra-indications to MMR, including; immunosuppression (i.e. proven, suspected, or planned); allergy to a component of the vaccine; receipt of a live-attenuated vaccine in the four weeks prior to inclusion; Vaccine refusal; Parental inability to follow the procedures of the study, e.g. due to language problems, psychological disorders, known/suspected non-compliance, substance abuse, etc; Any temporary contra-indication to MMR, including child being sick (active significant illness, inclusion can be delayed a few days until the illness resolves); Indication for an early MMR vaccination, including; Measles outbreak; Planned immunosuppression (indication to an accelerated schedule to be completed before starting an immunosuppressive treatment); Travel to a region with a high risk of measles outbreak; Indication for vaccination with MMR-varicella (MMRV) instead of MMR, including; severe eczema; parental will; Plan to move out of the country or have prolong absence during the trial; Other sibling included in the trial (in the case of multiple pregnancy, only one child can be randomised).