Checking for Hidden Cortisol Excess in Diabetes and Obesity
Checks how often hidden high cortisol occurs in adults with type 2 diabetes or obesity.
Key facts
- Who runs it
- Istituto Auxologico Italiano
- Where
- Milan, Roma, Siena, and Udine, ItalySee the 5 sites
- Trial code
- Registry title
- Type 2 Diabetes, Obesity and Cortisol Excess
- Status
- Recruiting
- People taking part
- 3,200 people, planned
- Started
- 6 May 2022
- Expected to end
- 31 Dec 2026
- Type of study
- Observational, 2 groups
- Treatments tested
- 1mg DST
- Record updated
- 10 November 2026
Who can take part
AI summary
From the trial's eligibility criteria. Machine-read from the registry text on this page, so it can be wrong. The registry text below and the trial team decide who can take part.
The trial is looking for adults aged 18 to 75 with type 2 diabetes and obesity. A second group of people with obesity but without type 2 diabetes is also included.
- Age
- 18 Years to 75 Years
- Sex
- All sexes can join.
- Disease stage
- Type 2 diabetes together with obesity. A second group has obesity without type 2 diabetes.
- Earlier treatment
- People taking drugs that influence the activity of the HPA axis cannot join.
Main reasons for not taking part
- Pregnancy or breast feeding
- Sleep apnea
- Symptoms of hypercortisolism
- Already known secondary hypertension
- Kidney disease (glomerular filtration rate <60)
The registry criteria, word for word
Show all 8 criteriaShow less
Who can take part
- patients with T2D and Obesity
Who cannot take part
- drugs influencing the HPA axis activity. For inclusion in Group 2 the presence of T2D will be an exclusion criteria
- prepuberal onset of hypertension, hormonal hypersecreting adrenal mass,
- already known secondary hypertension
- conditions associated with increased hypothalamic-pituitary-adrenal (HPA) axis activity, -severe autoimmune/rheumatologic and hematologic diseases, alcoholism, kidney disease (glomerular filtration rate <60)
- pregnancy/breast feeding,
- sleep apnea,
- symptoms of hypercortisolism
Check if you might fit
Answer for yourself. This is not a decision: only the study team can say whether you can take part.
- Are you between 18 and 75 years old?
Where in Italy
- Istituto Auxologico ItalianoMilan, ItalyContact: Valentina MorelliTaking people
- Niguarda HospitalMilan, ItalyContact: Iacopo Chiodini, ProfTaking people
- Campus Bio-Medico UniversityRoma, ItalyContact: Nicola Napoli, ProfTaking people
- University of SienaSiena, ItalyContact: Luigi Gennari, ProfTaking people
- Azienda Ospedaliero - Universitaria "Santa Maria della Misericordia" di UdineUdine, ItalyContact: Fabio Vescini, ProfTaking people
About the trial
What the trial wants to find out
The present observational cross-sectional study is aimed to assess: the hidden hypercortisolism (HidHyCo) prevalence in a sample of Type 2 diabetes (T2D) patients and the clinical characteristics more frequently associated with the HidHyCo presence and the HidHyCo prevalence in an adequate sample of obese patients without T2D and the clinical characteristics more frequently associated with the HidHyCo presence.
The 2 groups in the trial
- T2D
patients with Type2 diabetes (T2D)
Treatment: 1mg DST
- obese without T2D
obese patients without Type 2 diabetes (T2D)
Treatment: 1mg DST
Questions to ask the study team
- How often do I need to come in, and for how long each time?
- Are travel costs paid?
- Can I keep my own doctor?
- What happens if I want to stop?
Contact the study team: see the registry record → Contacts and Locations
Print a page for my doctorData and sources
- Registry record
- Listed on ClinicalTrials.gov.
- Official title
- Type 2 Diabetes, Obesity and Cortisol Excess
- Plain-language title
- Checking for Hidden Cortisol Excess in Diabetes and ObesityGenerated from the registry record. The registry title is the official one.
- AI summary
- From the trial's eligibility criteria. Read by machine on 12 November 2026.
- Fit questions
- Built from NCT05759637, who can take part
- Record updated
- 10 November 2026