Studying how aldosterone levels change over the day in primary aldosteronism
Observes whether aldosterone levels rise and fall over time in adults with primary aldosteronism.
Plain-language title generated from the registry record
Registry title: Diagnosing Variable Primary Aldosteronism.
Key facts
- Where
- London, United KingdomSee the site
Where in United Kingdom
- Queen Mary University of LondonLondon, United KingdomTaking people
Questions to ask the study team
- How often do I need to come in, and for how long each time?
- Are travel costs paid?
- Can I keep my own doctor?
- What happens if I want to stop?
Trial details
- Who runs it
- Queen Mary University of London
- Trial code
- NCT05765786
- Record updated
- 8 September 2026
- Original description
The goal of this observational study is to see if there is a cyclical or exaggerated diurnal variation in aldosterone production in people with Primary Aldosteronism.Read full original descriptionShow less
Do we Miss a Common Subset of Primary Aldosteronism in Which There is Cyclical or Exaggerated Diurnal Variation in Secretion?
The goal of this observational study is to see if there is a cyclical or exaggerated diurnal variation in aldosterone production in people with Primary Aldosteronism.
Inclusion: People with clinically suspected PA but have not met criteria for diagnosis. Suspicion based on low-renin (renin activity <0.5 nmol/h/L or renin mass <5 ng/L), plasma sodium > 140mmol/L or plasma potassium < 4mmol/L; Patients who have been diagnosed with PA and had previous aldosterone samples <277 pmol/L, a level which would normally not qualify for confirmatory testing; Patients with aldosterone results done at different times that indicate variability in production; Willing to consent and participate in the study.
Exclusion: Inability to withdraw β-adrenoceptor antagonist therapy for 2 weeks; People on end of life treatment.