Evaluation of Social Cognition in Patient With Type 1 or Type 2 Narcolepsy Versus Patients With Idiopathic Hypersomnia
Key facts
- Who runs it
- Centre Hospitalier Universitaire, Amiens
- Where
- Amiens, FranceSee the site
- Trial code
- Status
- Recruiting
- People taking part
- 75 people, planned
- Started
- 18 Nov 2022
- Expected to end
- May 2027
- Type of study
- Interventional, 3 groupsOne group gets an existing treatment, for comparison.
- Treatments tested
- Questionary
- Record updated
- 1 June 2026
Who can take part
- Age
- 18 years and older
- Sex
- Women and men
- Healthy volunteers
- Cannot take part
The registry criteria, word for word
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Who can take part
- adult patients (>/= 18years old)
- diagnosis of type 1 or type 2 narcolepsy or idiopathic hypersomnia
- non opposition
Who cannot take part
- comorbid psychiatric or neurologic disease
- patient under 18 years old
- patient under guardianship, curators or deprived of liberty, refusal of the patient
Where in France
- Chu Amiens PicardieAmiens, FranceContact: Mathilde FLAMAND, MDTaking people
About the trial
What the trial wants to find out
Narcolepsy is a chronic disabling neurologic disorder mainly characterised by excessive daytime sleepiness. Type 1 narcolepsy is associated with a deficit of hypocretin in the cerebrospinal fluid responsible for the cataplexy symptom while type 2 shows a normal hypocretin level and no cataplexy. While the development of narcolepsy is independent of parental social level, narcolepsy has a significant influence on educational level, grading, social outcome, and welfare consequences. Several studies assessed global cognition efficiency, mood, and attention in narcoleptic patients but only a few specifically measured social cognition and mostly without a control group.
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In a population of narcoleptics children, a severe impairment in social cognition is described for 20% of the group, contrary to 2 % for the control group. The literature also depicts some impairments in decision making, somatic and cognitive emotions responses but the emotion recognition seems to be preserved.
A better understanding of the social and cognitive aspects of narcolepsy could lead to a better treatment of the disease in its entirety, including if relevant specific cognitive behavioural therapy.
The protocol consists in a psychometric evaluation including several questionnaires in order to assess social cognition. It will be proposed to patients with type 1 or type 2 narcolepsy and patients with idiopathic hypersomnia.
The 3 groups in the trial
- NT1Treatment being tested
type 1 narcolepsy
Treatment: Questionary
- NT2Treatment being tested
type 2 narcolepsy
Treatment: Questionary
- HSIExisting treatment, for comparison
idiopathic hypersomnia
Treatment: Questionary
Questions to ask the study team
- How often do I need to come in, and for how long each time?
- Are travel costs paid?
- Can I keep my own doctor?
- What happens if I want to stop?
Contact the study team: see the registry record → Contacts and Locations
Print a page for my doctorData and sources
- Registry record
- Listed on ClinicalTrials.gov.
- Record updated
- 1 June 2026